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Acarbose controls postprandial hyperproinsulinemia in non-insulin dependent diabetes mellitus.

Abstract：

:We investigated how fasting or postprandial insulin levels were altered by treatment with acarbose or sulfonylureas. Plasma glucose and serum insulin, C-peptide, and proinsulin levels were measured before as well as 1 and 2 h after breakfast in 23 patients with non-insulin-dependent diabetes mellitus and 17 patients with impaired glucose tolerance. In the diabetic patients, 12 weeks of acarbose therapy decreased the postprandial levels of glucose (1 h: -60.0%; 2 h: -67.6%), insulin (1 h: -67.5%; 2 h: -72.2%) and proinsulin (1 h: -55.2%; 2 h: -46.7%), and proinsulin (1 h: -20.9%; 2 h: -57.5%). In contrast, sulfonylurea treatment increased postprandial insulin and proinsulin levels. Since increased in the serum insulin or proinsulin levels are associated with a higher risk of cardiovascular disease, the present findings suggest that the acarbose-induced reduction of the postprandial serum insulin or proinsulin responses to food intake might be useful for preventing vascular complications in patients with diabetes.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Inoue I,Takahashi K,Noji S,Awata T,Negishi K,Katayama S

doi

10.1016/s0168-8227(97)00045-4

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

143-51

issue

3

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(97)00045-4

journal_volume

36

pub_type

临床试验,杂志文章

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