Strength-duration properties in diabetic polyneuropathy.

Abstract:

:We sought to examine the changes in the strength-duration time constant (SDTC) of the median nerve in diabetic polyneuropathy. The SDTC is a measure of axonal excitability and depends on the biophysical properties of the axonal membrane. It may provide some information about Na(+) channel functioning. Forty-nine diabetic patients (30 men, 19 women; mean age, 54.6+/-9.4 years) and 15 age-matched healthy subjects (11 men, 4 women; mean age, 53.1+/-7.6 years) participated in the study. SDTC and rheobase values were 384.5+/-97.9 micros and 4.6+/-2.4 mA in patients and 313.8+/-46.7 micros and 6.0+/-2.6 mA in controls. The SDTC was found to be significantly different between the two groups (P=.009 for SDTC and P=.066 for rheobase). Fasting glucose and HbA1c levels of patients were 206.6+/-88.7 mg/dL and 8.8+/-2.4%, and these were not correlated with SDTC or rheobase (P<.05). We suggest that longer SDTC, indicating increased axonal excitability may develop in patients with polyneuropathy associated with uncontrolled diabetes.

authors

Yerdelen D,Koç F,Uysal H,Sarica Y

doi

10.1016/j.diabres.2007.03.001

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

56-9

issue

1

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(07)00149-0

journal_volume

78

pub_type

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