Prevalence of type 2 diabetes mellitus in a sample of the adult population of Alexandria, Egypt.

Abstract:

AIMS:To determine the prevalence of type 2 diabetes mellitus in a sample of the adult population of Alexandria, Egypt, and to delineate the epidemiologic profile of the disease in this community. METHODS:This cross-sectional study was conducted on a representative sample of the population. Participants provided demographic data, their medical history, and blood samples for measurement of plasma glucose (fasting and after oral glucose load) and underwent a detailed physical examination. RESULTS:Of 10,640 eligible subjects, 9657 (90.8%) aged 18-90 years agreed to participate (3795 men, 5862 women). We found an age-adjusted prevalence of diabetes of 16.8% (men, 12.7%; women 19.1%); of prediabetes, 14.6% (men, 13.5%; women, 15.2%), and of newly diagnosed diabetes, 5.5% (men, 3.3%; women, 6.6%). Diabetes was most common in people older than 50 years; prediabetes was most common in 30-39-year-old men and in women younger than 20. In logistic regression analysis, factors independently associated with prediabetes were a history of dyslipidaemia, urban residence, and widowhood. Independent associated factors for diabetes were a high waist-to-hip ratio, family history of diabetes, being divorced, history of dyslipidaemia, peripheral arterial disease or hypertension, low education level, and being not working. CONCLUSIONS:We found a high prevalence of diabetes and prediabetes in Alexandria, particularly in the middle-aged population. Given globally increasing life expectancies, the number of individuals with diabetes could become particularly challenging to the Egyptian healthcare system. Comprehensive national preventive measures are urgently needed.

authors

Assaad Khalil SH,Megallaa MH,Rohoma KH,Ismael H,AbouSeif M,Kharboush I,Elkaffash D,Hassanein M,Abdel Wahab MM,Malaty A,Sallam H

doi

10.1016/j.diabres.2018.07.025

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

63-73

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(17)31096-3

journal_volume

144

pub_type

杂志文章
  • Triglyceride to HDL-cholesterol ratio and the incidence risk of type 2 diabetes in community dwelling adults: A longitudinal 12-year analysis of the Korean Genome and Epidemiology Study.

    abstract:AIMS:Serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is known to be associated with cardiometabolic diseases. This study is aimed to evaluate the association between the TG/HDL-C ratio and incident type 2 diabetes with a large-sample, community-based Korean cohort over 12 years. METHODS:Amo...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2020.108150

    authors: Lim TK,Lee HS,Lee YJ

    更新日期:2020-05-01 00:00:00

  • Effect of ischemia on peripheral nerve function in diabetes mellitus.

    abstract::In Japan, diabetic patients are known to be able to sit on the floor for a prolonged time because of mildness or absence of ischemic paresthesia. In order to investigate this resistance to ischemia quantitatively, the mixed nerve function of the median nerve was studied during 30 min of ischemia using surface electrod...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/s0168-8227(86)80004-3

    authors: Kuriya N,Mori M,Miyake S,Takamori M,Nagataki S

    更新日期:1986-09-01 00:00:00

  • Clustering of components of the metabolic syndrome and risk for development of type 2 diabetes in Japanese male office workers.

    abstract::To investigate the effects of the clustering of components of the metabolic syndrome (MS) on development of diabetes, we examined 3298 Japanese male office workers aged 35-59 years who did not have type 2 diabetes (a fasting plasma glucose level of > or =7.0 mmol/l or receipt of hypoglycemic medication) or a history o...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2003.08.007

    authors: Nakanishi N,Nishina K,Okamoto M,Yoshida H,Matsuo Y,Suzuki K,Tatara K

    更新日期:2004-03-01 00:00:00

  • Challenges associated with treating children with diabetes in Saudi Arabia.

    abstract:BACKGROUND:Type 1 Diabetes Mellitus (T1DM) patients among the children have been increasing rapidly in the recent years in Saudi Arabia, as a result there is a need for extensive research in this area. Various suggestions were kept forward including m-health technologies, telemedicine etc. However, very little research...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2016.08.015

    authors: Alotaibi M,Alibrahim L,Alharbi N

    更新日期:2016-10-01 00:00:00

  • Relationship between age-adjusted heart rate and anaerobic threshold in estimating exercise intensity in diabetics.

    abstract::We compared heart rates at the anaerobic threshold (AT) with age-adjusted heart rates in two groups of diabetics (DMY, mean age 31; and DMO, mean age 48) to ascertain whether the AT is useful for evaluating the intensity of exercise therapy for diabetics. In both the DMY and DMO groups the AT was reached at lower hear...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/0168-8227(90)90098-e

    authors: Fujita Y,Kawaji K,Kanamori A,Matoba K,Yajima Y,Takeuchi A,Ishii K

    更新日期:1990-01-01 00:00:00

  • Impaired fasting plasma glucose is a risk indicator of interventricular septum thickening among non-diabetic subjects with obesity.

    abstract:AIMS:To evaluate whether progressively higher fasting plasma glucose (FPG) is associated to thickening of the interventricular septum (IVS) among non-diabetic subjects with obesity. METHODOLOGY:We studied 227 consecutive non diabetic patients (155 women and 72 men, age range 18-72 years) with overweight or obesity (BM...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2020.108436

    authors: Zupo R,Castellana F,Sardone R,Scicchitano P,Lampignano L,Ciccone MM,Triggiani V,Guastamacchia E,Giannelli G,De Pergola G

    更新日期:2020-11-01 00:00:00

  • Comparison of islet cell antibodies, islet cell surface antibodies and anti-bovine serum albumin antibodies in type 1 diabetes.

    abstract::The present study was undertaken to compare the changes in islet cell antibodies (ICA), islet cell surface antibodies using rat insulinoma cells (RINr-ICSA), and anti-bovine serum albumin antibodies (BSA-Ab) in the clinical course of type 1 (insulin-dependent) diabetes. Sera were obtained from 57 patients with type 1 ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/0168-8227(90)90047-w

    authors: Yokota A,Yamaguchi Y,Ueda Y,Nakanishi T,Ikari N,Akazawa S,Miyake S,Nagataki S

    更新日期:1990-07-01 00:00:00

  • Short-term aerobic exercise improves arterial stiffness in type 2 diabetes.

    abstract:OBJECTIVE:To investigate whether: (1) aerobic exercise decreases arterial stiffness and (2) reduction in arterial stiffness is associated with improvement in insulin resistance in type 2 diabetes. METHODS:Common carotid and femoral arterial stiffness was ultrasonographically evaluated using stiffness index beta in 23 ...

    journal_title:Diabetes research and clinical practice

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.diabres.2003.12.005

    authors: Yokoyama H,Emoto M,Fujiwara S,Motoyama K,Morioka T,Koyama H,Shoji T,Inaba M,Nishizawa Y

    更新日期:2004-08-01 00:00:00

  • Ten-year mortality and glucose tolerance status in an elderly Finnish population.

    abstract::The aim of this study was to determine the 10-year mortality rate of an elderly population aged 70 years or over (n=379) with reference to glucose tolerance status, taking into account other determinants of excess mortality. The baseline examination during 1991-1992 included a postal questionnaire, a physical examinat...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2004.11.004

    authors: Hiltunen L

    更新日期:2005-07-01 00:00:00

  • The effects of lipoic acid and α-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial.

    abstract::Antioxidants probably play an important role in the etiology of type 2 diabetes (DM2). This study evaluated the effects of supplementation with lipoic acid (LA) and α-tocopherol on the lipid profile and insulin sensitivity of DM2 patients. A randomized, double-blind, placebo-controlled trial involving 102 DM2 patients...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.diabres.2011.02.010

    authors: de Oliveira AM,Rondó PH,Luzia LA,D'Abronzo FH,Illison VK

    更新日期:2011-05-01 00:00:00

  • Haemodynamic and other effects of sulphonylurea drugs on the heart.

    abstract::Antidiabetic sulphonylureas have attracted a great deal of interest in experimental cardiology to evaluate the role of ATP-sensitive potassium channels in the cardiovascular system. It is well established that KATP channels are present in cardiac cells and also in vascular smooth muscle cells and are implicated in the...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/0168-8227(96)01229-6

    authors: Végh A,Papp JG

    更新日期:1996-07-01 00:00:00

  • The effects of sitagliptin, a DPP-4 inhibitor, on cognitive functions in elderly diabetic patients with or without Alzheimer's disease.

    abstract:AIMS:The present study aimed to evaluate effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4I), on cognitive functions in elderly diabetic patients with and without cognitive impairment. METHODS:253 elderly patients with type 2DM, were enrolled in this prospective and observational study. After comprehens...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2016.12.010

    authors: Isik AT,Soysal P,Yay A,Usarel C

    更新日期:2017-01-01 00:00:00

  • The effect of an aldose reductase inhibitor on cardiovascular performance in patients with diabetes mellitus.

    abstract::Because some aldose reductase inhibitor studies have demonstrated clinical improvement in scored neurological signs and symptoms of diabetic neuropathy, a prospective study of the effect on cardiovascular performance of sorbinil 250 mg/day for 12 months was conducted on patients with diabetic autonomic neuropathy who ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/0168-8227(90)90086-9

    authors: Roy TM,Broadstone VL,Peterson HR,Snider HL,Cyrus J,Fell R,Rothchild AH,Samols E,Pfeifer MA

    更新日期:1990-08-01 00:00:00

  • Short term optimization of glycaemic control using insulin improves sympatho-vagal tone activities in patients with type 2 diabetes.

    abstract:INTRODUCTION:Diabetic cardiac autonomic neuropathy (CAN) is potentially life threatening and its severity might further be aggravated by poor glycaemic control. A decrease in Heart rate variability (HRV) is the earliest finding of CAN even at the sub clinical stage. While intensive glycaemic control prevents the develo...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2019.107875

    authors: Mba CM,Nganou-Gnindjio CN,Azabji-Kenfack M,Mfeukeu-Kuate L,Dehayem MY,Mbanya JC,Sobngwi E

    更新日期:2019-11-01 00:00:00

  • Changing prevalence of retinopathy in newly diagnosed non-insulin dependent diabetes mellitus patients in Hong Kong.

    abstract::In this retrospective study, the prevalence of chronic microangiopathic complications was determined in 474 Chinese patients with non-insulin dependent diabetes mellitus (NIDDM) who presented within 1 year of diagnosis to the diabetes clinic from January 1990 to December 1996. Mean age (+/- S.E.) was 53.6 (+/- 0.6) ye...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/s0168-8227(98)00002-3

    authors: Wang WQ,Ip TP,Lam KS

    更新日期:1998-03-01 00:00:00

  • Impact of blood glucose monitoring affect on family conflict and glycemic control in adolescents with type 1 diabetes.

    abstract:BACKGROUND:This longitudinal study examined whether diabetes-specific family conflict and glycemic control were impacted/explained by negative affective responses to blood glucose checks (Negative BGM Affect). METHOD:Adolescents (N=150, ages 13-18 years) with type 1 diabetes, and their caregivers, completed measures o...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2011.12.020

    authors: Gray WN,Dolan LM,Hood KK

    更新日期:2013-02-01 00:00:00

  • Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.

    abstract:AIM:To assess the relationship between acarbose and hepatotoxicity, cardiovascular disease (CVD), and mortality among type 2 diabetes (T2D) patients with end-stage renal disease (ESRD). METHODS:32,531 T2D patients with ESRD were identified from Taiwan's National Health Insurance Research Database in 2000~∼2012 and fol...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2020.108489

    authors: Lin WH,Yang CY,Kuo S,Kuo TH,Roan JN,Li CY,Wang MC,Ou HT

    更新日期:2020-10-06 00:00:00

  • A report on the diagnosis of intermediate hyperglycemia in Korea: A pooled analysis of four community-based cohort studies.

    abstract::Many studies show poor agreement between fasting plasma glucose (FPG)-based and 2-h postchallenge glucose (2-h PG)-based criteria to assess glucose metabolism. We examined the rate of agreement between FPG- and 2-h PG-based criteria in the diagnosis of intermediate hyperglycemia in four representative cohort studies i...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.diabres.2008.01.022

    authors: Oh JY,Lim S,Kim DJ,Kim NH,Kim DJ,Moon SD,Jang HC,Cho YM,Song KH,Ahn CW,Sung YA,Park JY,Shin C,Lee HK,Park KS,Committee of the Korean Diabetes Association on the Diagnosis and Classification of Diabetes Mellitus.

    更新日期:2008-06-01 00:00:00

  • Triglycerides-diabetes association in healthy middle-aged men: modified by physical fitness? A long term follow-up of 1962 Norwegian men in the Oslo Ischemia Study.

    abstract:AIMS:To examine the impact of physical fitness (PF) on the association between fasting serum triglycerides (FTG) and diabetes risk and whether temporal changes in FTG predict diabetes risk in healthy middle-aged men. METHODS:FTG and PF (bicycle exercise test) were measured in 1962 men aged 40-59 years in 1972-1975 (Su...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2013.06.001

    authors: Skretteberg PT,Grytten AN,Gjertsen K,Grundvold I,Kjeldsen SE,Erikssen J,Mellbin L,Liestøl K,Fraser DA,Erikssen G,Pedersen TR,Bodegard J

    更新日期:2013-08-01 00:00:00

  • Lipasin, a biomarker of diabetic retinopathy.

    abstract::The present study recruited 74 participants with type 2 diabetes, among which 23 had retinopathy. Those with retinopathy had a longer duration of diabetes and higher levels of lipasin compared with those without retinopathy. Logistic regression revealed that lipasin was independently and significantly associated with ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2016.01.029

    authors: Fang C,Huang Y,Guo H,Gao Y,Ji X,Hu J

    更新日期:2016-05-01 00:00:00

  • Isoprostanes, a marker of lipid peroxidation, may not be involved in the development of glucose intolerance.

    abstract::We investigated whether isoprostanes, as a marker of lipid peroxidation, may be involved in the development of impaired glucose tolerance (IGT) or diabetes. Using a nested case-control study, we tracked the changes in isoprostane levels, insulin sensitivity (IS) and beta-cell function (BCF) in Afro-Jamaicans who progr...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2006.08.003

    authors: Boyne MS,Sargeant LA,Bennett FI,Wilks RJ,Cooper RS,Forrester TE

    更新日期:2007-04-01 00:00:00

  • The modulating effects of the overexpression of uncoupling protein 2 on the formation of reactive oxygen species in vascular cells.

    abstract::Uncoupling protein 2 (UCP-2) is a newly identified member of the mitochondrial anion carrier family and shares 60% sequence identity with the well-characterized thermogenic UCP-1 from brown adipose tissue. Several lines of evidence suggest that UCP-2 is involved in the control of reactive oxygen species (ROS) producti...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2007.01.032

    authors: Kim HS,Park KG,Koo TB,Huh S,Lee IK

    更新日期:2007-09-01 00:00:00

  • Education, glucose control, and mortality risks among U.S. older adults with diabetes.

    abstract:AIMS:Studies have shown that diabetes mellitus disproportionately afflicts persons of low socioeconomic status and that the burden of disease is greatest among the disadvantaged. However, our understanding of educational differences in the control of diabetes and its impact on survival is limited. This study investigat...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2014.12.013

    authors: Dupre ME,Silberberg M,Willis JM,Feinglos MN

    更新日期:2015-03-01 00:00:00

  • Global perspectives on the provision of diabetic retinopathy screening and treatment: Survey of health care professionals in 41 countries.

    abstract:AIM:To assess the level of awareness and provision of screening and treatment for Diabetic Eye Disease (DED) comprising Diabetic Retinopathy (DR) and Diabetic Macular Edema (DME) among health care professionals. METHODS:The study was conducted in two phases. The first phase consisted of a qualitative study, based on s...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.diabres.2018.07.004

    authors: Cavan D,Makaroff LE,da Rocha Fernandes J,Karuranga S,Sylvanowicz M,Conlon J,Chaney D,Malhi A,Barratt J

    更新日期:2018-09-01 00:00:00

  • Short sleep duration and type 2 diabetes enhance the risk of cardiovascular events in hypertensive patients.

    abstract:AIMS:We tested the hypothesis that short sleep duration is not only a risk factor for diabetes, but that the two conditions in combination would be associated with the risk of incident cardiovascular disease (CVD). METHODS:We analyzed 1255 hypertensive patients (mean age: 70.4±9.9 years) with (N=299) and without diabe...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2012.09.014

    authors: Eguchi K,Hoshide S,Ishikawa S,Shimada K,Kario K

    更新日期:2012-12-01 00:00:00

  • Design and development of the Hypoglycaemia Symptom Rating Questionnaire (HypoSRQ).

    abstract:AIMS:To evaluate the Hypoglycaemia Symptom Rating Questionnaire (HypoSRQ©) and relationships between self-reported hypoglycaemia and hypoglycaemia measured using blinded continuous glucose monitoring (CGM). METHODS:Diabetes outpatients (n = 113) recruited from Ashford and St. Peter's Hospital completed the HypoSRQ (re...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2019.04.010

    authors: Taylor MD,Han TS,Ward H,Bradley C

    更新日期:2019-05-01 00:00:00

  • Sulfonylurea and fracture risk in patients with type 2 diabetes mellitus: A meta-analysis.

    abstract:AIMS:This meta-analysis was conducted to investigate the fracture risk among patients with T2DM treated with sulfonylurea. METHODS:The PubMed and other databases were searched for eligible studies. Both randomized controlled trials and observational studies that compared the fracture risk of sulfonylurea to other hypo...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.diabres.2019.107990

    authors: Zhang Z,Cao Y,Tao Y,E M,Tang J,Liu Y,Li F

    更新日期:2020-01-01 00:00:00

  • Influence of cardiovascular autonomic neuropathy on atherogenesis and heart function in patients with type 1 diabetes.

    abstract:AIM:Cardiovascular autonomic neuropathy (CAN) increases mortality of patients with type 1 diabetes (Type 1 DM). We set out to find out whether the presence of CAN in asymptomatic, normotensive Type 1 DM affects endothelial function (marker of atherogenesis) and left ventricle function (marker of cardiomyopathy). METHO...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2008.09.007

    authors: Lacigova S,Bartunek L,Cechurova D,Visek J,Gruberova J,Krcma M,Jankovec Z,Rusavy Z,Zourek M

    更新日期:2009-01-01 00:00:00

  • Smoking, blood glucose control, and locus of control beliefs in people with type 1 diabetes mellitus.

    abstract::The relations between blood glucose control (HbA(1c)), smoking, and health-related diabetes locus of control beliefs were studied in a consecutive adult sample of 187 patients with Type 1 diabetes who were free of diabetes complications. Those who were smokers (n=32) had poorer HbA(1c) values than non-smokers [7.5+/-1...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/s0168-8227(00)00169-8

    authors: Stenström U,Andersson P

    更新日期:2000-10-01 00:00:00

  • Insulin resistance and diabetes, mechanism and possible intervention.

    abstract::The issue of the peripheral resistance to insulin action has been getting a lot of attention over the last decade. The reason for this is that insulin is a major regulatory hormone and is involved in the metabolism of carbohydrates, lipids, protein and ions. To understand the pathophysiology of insulin resistance it i...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/0168-8227(89)90098-3

    authors: Koffler M,Ramirez LC,Raskin P

    更新日期:1989-08-01 00:00:00