Effect of aging on plasma 1,5-anhydroglucitol levels in humans and rats.

Abstract:

:Since normal reference values change with age in some clinical parameters, we measured the plasma levels of 1,5-anhydroglucitol (AG), a new marker of glycemic control in diabetes mellitus, in healthy subjects and in rats. Our results showed a significantly negative correlation of the marker with age in humans and that the plasma AG levels of older rats were markedly lower than those of younger counterparts. This remarkable reduction of AG in the older rat group can be partially explained by our finding that aged animals excreted AG more rapidly in the urine than younger ones, besides a decrease in food intake. We therefore suggest that normal clinical reference values for plasma AG levels should be modified according to age.

authors

Funasako M,Taniji M,Fujimoto K,Ohata M,Higashimoto Y,Uetani K,Suruda T,Nakai S,Fujimoto H,Sakagami Y

doi

10.1016/0168-8227(94)90159-7

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

35-41

issue

1

eissn

0168-8227

issn

1872-8227

pii

0168-8227(94)90159-7

journal_volume

25

pub_type

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