当前位置： SCI文献检索 > DIABETES RESEARCH AND CLINICAL PRACTICE期刊下所有文献 > Gln-Arg192 polymorphism of paraoxonase 1 is associated with carotid intima-media thickness in patients of type 2 diabetes mellitus of Chinese.

Gln-Arg192 polymorphism of paraoxonase 1 is associated with carotid intima-media thickness in patients of type 2 diabetes mellitus of Chinese.

Abstract：

:Serum paraoxonase (PON) is a high-density lipoprotein-bound enzyme that can prevent oxidation of low-density lipoprotein by hydrolyzing lipid peroxides and thus exert an anti-atherogenic effect. Recent studies have suggested that glutamine(Q isoform)/arginine(R isoform) polymorphism at position 192 of PON(1) gene is associated with macrovascular disease of type 2 diabetes mellitus (T2DM). We re-investigated this relationship using carotid intima-media thickness (IMT) as a surrogate continuous variable for macroangiopathy. The genotype and allele frequency of PON(1) 192 Q/R polymorphism was assayed by polymerase chain reaction-restriction fragment length polymorphism in 152 type 2 diabetic patients and 128 healthy subjects from a population of Chinese Han nationality in ChengDu area. The carotid IMT was measured by B-mode ultrasonography in type 2 diabetic patients. No differences were found in PON(1) gene Q/R polymorphism in the type 2 diabetic patients when compared with the control group. The mean carotid IMT in type 2 diabetic subjects with the QQ, QR and RR genotype was 0.65+/-0.27, 0.83+/-0.27 and 1.05+/-0.32 mm, respectively. One-way ANOVA showed that IMT was significantly greater in the RR subgroup than in both QR and QQ subgroups (P<0.01). Multivariate logistic regression analysis showed R allele to be the main determinant of IMT variability (OR 4.0 95% CI 2.10-7.40 P=0.005). Our data support the view that 192 R allele of PON(1) gene is a risk factor for macrovascular disease of T2DM in Chinese.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Hu Y,Tian H,Liu R

doi

10.1016/s0168-8227(03)00058-5

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

21-7

issue

1

eissn

0168-8227

issn

1872-8227

pii

S0168822703000585

journal_volume

61

pub_type

杂志文章

相关文献

DIABETES RESEARCH AND CLINICAL PRACTICE文献大全
  • Prognostic nomogram and score to predict renal survival of patients with biopsy-proven diabetic nephropathy.

    abstract：AIMS:Both clinical and pathogenetic markers for accurate prediction of end-stage renal disease in diabetic nephropathy (DN) are lacking. This study aimed to establish an effective prognostic nomogram and a score for renal survival (RS) in biopsy-proven DN. METHODS:Analyses were derived from 110 DN patients who underwe...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2019.107809

    authors： Jiang S,Yu T,Zhang Z,Fang J,Wang Y,Yang Y,Liu L,Zou G,Gao H,Zhuo L,Li W

    更新日期：2019-09-01 00:00:00

  • Behavioral strategies in diabetes prevention programs: a systematic review of randomized controlled trials.

    abstract：UNLABELLED:The worldwide epidemic of type 2 diabetes (T2D) emphasizes the need for guidelines regarding community implementation of lifestyle modification prevention programs. An understanding of effective behavioral strategies is needed if evidence translation is to be realized. The aim of this paper is to systematica...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabres.2010.06.030

    authors： Baker MK,Simpson K,Lloyd B,Bauman AE,Singh MA

    更新日期：2011-01-01 00:00:00

  • The mechanism of exaggerated glucagon response to arginine in diabetes mellitus.

    abstract：:As far as exaggerated arginine-induced glucagon secretion in diabetics is concerned, the authors have shown that both the restoration of blood glucose excursions and physiological insulinemia in response to arginine, obtained from an artificial endocrine pancreas (AEP) could normalize the glucagon secretory responses ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(85)80002-4

    authors： Kawamori R,Shichiri M,Kikuchi M,Yamasaki Y,Abe H

    更新日期：1985-10-01 00:00:00

  • Sodium-glucose cotransporter 2 inhibitors and fracture risk in patients with type 2 diabetes mellitus: A systematic literature review and Bayesian network meta-analysis of randomized controlled trials.

    abstract：AIM:To perform a systematic literature review and network meta-analysis (NMA) of randomized controlled trials (RCTs) to estimate effect of SGLT2 inhibitors on fracture risk in patients with T2DM. METHODS:A systematic search was performed on PubMed/Medline and ClinicalTrials.gov from inception to May 2018 to identify R...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2018.10.019

    authors： Azharuddin M,Adil M,Ghosh P,Sharma M

    更新日期：2018-12-01 00:00:00

  • The influence of different insulin regimens on quality of life and metabolic control in insulin-dependent diabetics.

    abstract：:Administration of insulin with premeal boluses of short-acting insulin using a new injection device (Novopen) was compared with a conventional three times daily injection regimen regarding aspects of quality of life and metabolic control in insulin-dependent diabetes mellitus (IDDM). Eighteen C-peptide-negative patien...

    journal_title：Diabetes research and clinical practice

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0168-8227(89)90055-7

    authors： Tallroth G,Karlson B,Nilsson A,Agardh CD

    更新日期：1989-01-03 00:00:00

  • The effect of intensive risk factor management in type 2 diabetes on inflammatory biomarkers.

    abstract：AIMS:To determine whether intensive risk factor management reduced markers of inflammation in middle-aged and older people with type 2 diabetes who either had, or were at risk for cardiovascular disease (CVD), and whether these effects were mediated by adiposity. METHODS:The Action to Control Cardiovascular Risk in Di...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.diabres.2011.09.027

    authors： Samaropoulos XF,Light L,Ambrosius WT,Marcovina SM,Probstfield J,Goff DC Jr

    更新日期：2012-03-01 00:00:00

  • Prevalence of Diabetes, Management and Outcomes among Covid-19 Adult Patients Admitted in a Specialized Tertiary Hospital in Riyadh, Saudi Arabia.

    abstract：:This retrospective study aimed to characterize comorbidities and associated with mortality among hospitalized adults with Covid-19 managed as perthe Saudi Ministry of Health protocol in a specialized tertiary hospital in Riyadh, Saudi Arabia. Medical records of 300 adult patients with PCR-confirmed SARS-CoV2 infection...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108538

    authors： Sheshah E,Sabico S,Albakr RM,Sultan AA,Alghamdi KS,Al Madani K,Alotair HA,Al-Daghri NM

    更新日期：2020-11-12 00:00:00

  • Importance of OGTT for diagnosing diabetes mellitus based on prevalence and incidence of retinopathy.

    abstract：:Study was made on the necessity and importance of the oral glucose tolerance test (OGTT) for diagnosing diabetes mellitus based on prevalence and incidence of diabetic retinopathy. Subjects were 12208 persons undergoing OGTT between 1965 and 1997. The prevalence of retinopathy was significantly elevated with FPG>/=126...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(00)00156-x

    authors： Ito C,Maeda R,Ishida S,Harada H,Inoue N,Sasaki H

    更新日期：2000-08-01 00:00:00

  • Impact of an acceptance facilitating intervention on diabetes patients' acceptance of Internet-based interventions for depression: a randomized controlled trial.

    abstract：AIMS:To (1) determine diabetes patients' acceptance of Internet-based interventions (IBIs) for depression, to (2) examine the effectiveness of an acceptance facilitating intervention (AFI) and to (3) explore subgroup specific effects. METHODS:141 diabetes patients from two inpatient rehabilitation units and one outpat...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.diabres.2014.04.031

    authors： Baumeister H,Nowoczin L,Lin J,Seifferth H,Seufert J,Laubner K,Ebert DD

    更新日期：2014-07-01 00:00:00

  • The effects of sitagliptin, a DPP-4 inhibitor, on cognitive functions in elderly diabetic patients with or without Alzheimer's disease.

    abstract：AIMS:The present study aimed to evaluate effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4I), on cognitive functions in elderly diabetic patients with and without cognitive impairment. METHODS:253 elderly patients with type 2DM, were enrolled in this prospective and observational study. After comprehens...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2016.12.010

    authors： Isik AT,Soysal P,Yay A,Usarel C

    更新日期：2017-01-01 00:00:00

  • Metformin in combination with various insulin secretagogues in type 2 diabetes and associated risk of cardiovascular morbidity and mortality--a retrospective nationwide study.

    abstract：AIMS:Metformin is the first-line treatment for most patients with type 2 diabetes but many patients need additional treatment with insulin secretagogues (IS) to achieve glycemic control. We aimed to compare mortality and cardiovascular risk among users of metformin in combination with pharmacologically different ISs. ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2014.09.047

    authors： Mogensen UM,Andersson C,Fosbøl EL,Schramm TK,Vaag A,Scheller NM,Torp-Pedersen C,Gislason G,Køber L

    更新日期：2015-01-01 00:00:00

  • Age of diabetes diagnosis and diabetes duration associate with glycated haemoglobin.

    abstract：:An earlier age of diagnosis (r=-0.28, p<0.0001) and longer duration of type 2 diabetes (r=0.26, p<0.0001) were each found to correlate with higher HbA1c level, on analysis of a diabetes centre database in people under regular shared care. When combined, these biological variables strongly associate with the current Hb...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2014.02.004

    authors： Hsieh A,Ong PX,Molyneaux L,McGill MJ,Constantino M,Wu T,Wong J,Yue DK,Twigg SM

    更新日期：2014-04-01 00:00:00

  • Impact of diabetes on fibrinogen levels and its relationship with platelet reactivity and coronary artery disease: A single-centre study.

    abstract：BACKGROUND:Previous reports have suggested an association between elevated fibrinogen and CAD. Few studies have so far investigated the impact of diabetes on fibrinogen levels and its association with coronary artery disease (CAD) and platelet reactivity in diabetic patients that are therefore the aims of the current s...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2015.05.038

    authors： Di Giovine G,Verdoia M,Barbieri L,Schaffer A,Aimaretti G,Bellomo G,Marino P,Suryapranata H,Sinigaglia F,De Luca G,Novara Atherosclerosis Study (NAS) group.

    更新日期：2015-09-01 00:00:00

  • The metabolic syndrome and incident diabetes: Assessment of alternative definitions of the metabolic syndrome in an Iranian urban population.

    abstract：AIMS:To compare the ability of definitions of Metabolic Syndrome (MetS) in the prediction of type 2 diabetes. METHODS:We examined 4756 subjects in an Iranian population who were non-diabetic at baseline. After 3.6 years, 188 individuals developed diabetes. RESULTS:Impaired glucose tolerance (IGT) and MetS definitions...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2008.01.003

    authors： Hadaegh F,Ghasemi A,Padyab M,Tohidi M,Azizi F

    更新日期：2008-05-01 00:00:00

  • The modulating effects of the overexpression of uncoupling protein 2 on the formation of reactive oxygen species in vascular cells.

    abstract：:Uncoupling protein 2 (UCP-2) is a newly identified member of the mitochondrial anion carrier family and shares 60% sequence identity with the well-characterized thermogenic UCP-1 from brown adipose tissue. Several lines of evidence suggest that UCP-2 is involved in the control of reactive oxygen species (ROS) producti...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2007.01.032

    authors： Kim HS,Park KG,Koo TB,Huh S,Lee IK

    更新日期：2007-09-01 00:00:00

  • Saxagliptin is similar in glycaemic variability more effective in metabolic control than acarbose in aged type 2 diabetes inadequately controlled with metformin.

    abstract：:This study compared the effects on glycaemic variability and glucose control between saxagliptin and acarbose as add-on therapies for aged T2DM inadequately controlled with metformin alone. The results showed that compared with acarbose-metformin, saxagliptin-metformin was more effective in glucose control with simila...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.diabres.2015.02.022

    authors： Wang MM,Lin S,Chen YM,Shu J,Lu HY,Zhang YJ,Xie RY,Zeng LY,Mu PW

    更新日期：2015-06-01 00:00:00

  • Clinical predictors differentiating non-diabetic renal diseases from diabetic nephropathy in a large population of type 2 diabetes patients.

    abstract：AIMS:Non-diabetic renal diseases (NDRDs) are associated with better renal outcomes than diabetic nephropathy (DN). This study was conducted to determine the common clinical markers predicting NDRDs in type 2 diabetes patients. METHODS:Patients with type 2 diabetes mellitus who underwent a renal biopsy were screened. E...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2016.09.005

    authors： Dong Z,Wang Y,Qiu Q,Zhang X,Zhang L,Wu J,Wei R,Zhu H,Cai G,Sun X,Chen X

    更新日期：2016-11-01 00:00:00

  • Evolution of OGTT in patients with beta-thalassaemia major in relation to chelation therapy.

    abstract：:Glucose metabolism disturbances are frequently reported among patients with beta-thalassaemia major on conventional treatment consisted of regular blood transfusions and adequate chelation treatment. Aim of this study was to evaluate the evolution of oral glucose tolerance test (OGTT) in thalassaemic patients in relat...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2006.07.010

    authors： Christoforidis A,Perifanis V,Tsatra I,Vlachaki E,Athanassiou-Metaxa M

    更新日期：2007-04-01 00:00:00

  • The metabolic syndrome in Australia: prevalence using four definitions.

    abstract：OBJECTIVE:To compare the prevalence of the Metabolic Syndrome (MetS) defined by four definitions and to determine which definition best identifies those at high cardiovascular disease (CVD) risk and with insulin resistance. METHODS:AusDiab is a population-based survey of 11,247 Australians. Participants had anthropome...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2007.02.002

    authors： Cameron AJ,Magliano DJ,Zimmet PZ,Welborn T,Shaw JE

    更新日期：2007-09-01 00:00:00

  • Association of Chlamydia pneumoniae infection with diabetic nephropathy.

    abstract：:We evaluated the association of Chlamydia pneumoniae (CP) infection with progression of diabetic nephropathy. Type 2 diabetic patients (60) were divided into two groups, those with incipient nephropathy and those with advanced nephropathy, based on the severity of diffuse glomerular lesions using Gellman's criteria. T...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(99)00108-4

    authors： Kanauchi M,Kawano T,Dohi K

    更新日期：2000-01-01 00:00:00

  • Sulfonylurea and fracture risk in patients with type 2 diabetes mellitus: A meta-analysis.

    abstract：AIMS:This meta-analysis was conducted to investigate the fracture risk among patients with T2DM treated with sulfonylurea. METHODS:The PubMed and other databases were searched for eligible studies. Both randomized controlled trials and observational studies that compared the fracture risk of sulfonylurea to other hypo...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.diabres.2019.107990

    authors： Zhang Z,Cao Y,Tao Y,E M,Tang J,Liu Y,Li F

    更新日期：2020-01-01 00:00:00

  • Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women.

    abstract：AIM:The aim of this study was to examine the association of serum bilirubin, an endogenous antioxidant, with serum high sensitivity C-reactive protein (hs-CRP) level, HbA(1c), and the prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women (n=12,400). METHODS:Analysis of covariance and logistic...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2009.12.022

    authors： Ohnaka K,Kono S,Inoguchi T,Yin G,Morita M,Adachi M,Kawate H,Takayanagi R

    更新日期：2010-04-01 00:00:00

  • Relationship between metabolic syndrome components and vascular properties in Japanese type 2 diabetic patients without cardiovascular disease or nephropathy.

    abstract：:To investigate the effect of metabolic syndrome (MS) components on early atherosclerosis markers, i.e., urinary albumin excretion rate (UAE), pulse wave velocity (PWV), and carotid intima-media thickness (IMT), we studied 536 Japanese patients with type 2 diabetes without cardiovascular disease or nephropathy. The MS ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2006.06.015

    authors： Yokoyama H,Kuramitsu M,Kanno S,Tada J,Yokota Y,Kamikawa F

    更新日期：2007-02-01 00:00:00

  • Increased serum pigment epithelium-derived factor levels in type 1 diabetic patients with diabetic retinopathy.

    abstract：:Serum pigment epithelium-derived factor (PEDF) levels were significantly higher in type 1 diabetic patients with retinopathy (n=20, 10.38+/-3.87 microg/ml) compared to the patients without it (n=57, 7.68+/-2.80 microg/ml) (p=0.0013). Elevated PEDF levels may be related to the progression of diabetic retinopathy. ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2008.03.009

    authors： Katakami N,Kaneto H,Yamasaki Y,Matsuhisa M

    更新日期：2008-07-01 00:00:00

  • Effect of different glucose-lowering therapies on cancer incidence in type 2 diabetes: An observational population-based study.

    abstract：AIM:To assess the effect of metformin on cancer incidence in type 2 diabetes (T2DM), considering possible interactions with other glucose-lowering drugs and diabetes duration. METHODS:Study cohort included diabetes patients aged 20-84 on December 2009, still alive and resident in Reggio Emilia province as of December ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabres.2018.04.036

    authors： Vicentini M,Ballotari P,Giorgi Rossi P,Venturelli F,Sacchettini C,Greci M,Mangone L,Pezzarossi A,Manicardi V

    更新日期：2018-09-01 00:00:00

  • Overcoming disparities in diabetes care: eight years' experience changing the diabetes care system in Changhua, Taiwan.

    abstract：AIMS:To enhance the universal coverage of quality diabetes care and overcome disparities in care among different care-provider levels by changing the diabetes care system in Changhua, Taiwan. METHODS:The Changhua Diabetes Shared Care program's second stage commenced in 2004. Two levels of diabetes care were proposed t...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究

    doi：10.1016/S0168-8227(14)70736-3

    authors： Yeh YP,Chang CJ,Hsieh ML,Wu HT

    更新日期：2014-12-01 00:00:00

  • Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes.

    abstract：:It is recognized that a chronic low-grade inflammation and an activation of the immune system are involved in the pathogenesis of obesity-related insulin resistance and type 2 diabetes. Systemic inflammatory markers are risk factors for the development of type 2 diabetes and its macrovascular complications. Adipose ti...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabres.2014.04.006

    authors： Esser N,Legrand-Poels S,Piette J,Scheen AJ,Paquot N

    更新日期：2014-08-01 00:00:00

  • Insulin degludec/insulin aspart versus biphasic insulin aspart 30 in Asian patients with type 2 diabetes inadequately controlled on basal or pre-/self-mixed insulin: a 26-week, randomised, treat-to-target trial.

    abstract：AIMS:Insulin degludec/insulin aspart (IDegAsp) is a soluble co-formulation of IDeg and IAsp. This pan-Asian, 26-week trial investigated efficacy and safety of IDegAsp vs biphasic insulin aspart 30 (BIAsp 30) in Asian adults with type 2 diabetes (T2DM), inadequately controlled on once- or twice-daily (BID) basal, premix...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.diabres.2014.09.026

    authors： Kaneko S,Chow F,Choi DS,Taneda S,Hirao K,Park Y,Andersen TH,Gall MA,Christiansen JS,BOOST: Intensify All Trial Investigators.

    更新日期：2015-01-01 00:00:00

  • Management of type 2 diabetes in Western Australian metropolitan general practice.

    abstract：:The purpose of this study was: (1) to record GP opinions, practices and outcomes for the care of Type 2 Diabetes Mellitus (DM2), (2) compare practice facilities and process of care with a criterion of recommended competent care and (3) determine if there were any differences between vocationally registered and non-voc...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(94)90061-2

    authors： Kamien M,Ward AM,Mansfield F,Fatovich B,Mather C,Anstey K

    更新日期：1994-12-31 00:00:00

  • Preconception care of women attending adult general diabetes clinics--are we doing enough?

    abstract：BACKGROUND:The presence of diabetes in pregnancy can result in substantial morbidity to both mother and baby if management is sub-optimal. AIMS:To assess the process of standards of preconception care (against the National Service Framework standards) of women attending the adult general diabetes clinics in a district...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2006.07.025

    authors： Varughese GI,Chowdhury SR,Warner DP,Barton DM

    更新日期：2007-04-01 00:00:00