Association of Chlamydia pneumoniae infection with diabetic nephropathy.

Abstract:

:We evaluated the association of Chlamydia pneumoniae (CP) infection with progression of diabetic nephropathy. Type 2 diabetic patients (60) were divided into two groups, those with incipient nephropathy and those with advanced nephropathy, based on the severity of diffuse glomerular lesions using Gellman's criteria. Type 2 (34) diabetic patients without nephropathy (normoalbuminuria) and 59 nondiabetics served as control groups. Serum IgG-antibody against CP was measured using ELISA. CP antibody was detected in 45.8% of nondiabetic controls, in 47.1% of diabetic patients without nephropathy, in 52.6% of diabetic patients with incipient nephropathy, and 78% of diabetic patients with advanced nephropathy. There was 4.22-fold increase in the risk of advanced nephropathy associated with the presence of CP antibody. Our findings indicate an association between chronic CP infection and advanced diabetic nephropathy.

authors

Kanauchi M,Kawano T,Dohi K

doi

10.1016/s0168-8227(99)00108-4

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

45-8

issue

1

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(99)00108-4

journal_volume

47

pub_type

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