Abstract:
AIMS:Insulin degludec/insulin aspart (IDegAsp) is a soluble co-formulation of IDeg and IAsp. This pan-Asian, 26-week trial investigated efficacy and safety of IDegAsp vs biphasic insulin aspart 30 (BIAsp 30) in Asian adults with type 2 diabetes (T2DM), inadequately controlled on once- or twice-daily (BID) basal, premixed or self-mixed insulin. METHODS:Participants (mean age 59.8 years, HbA1c 8.4%, FPG 7.9 mmol/L, BMI 25.4 kg/m(2)) were randomised 2:1 to BID IDegAsp (n=282) or BIAsp 30 (n=142) and continued existing metformin treatment. Insulins were administered with breakfast and main evening meal, titrated to a pre-breakfast and pre-main evening meal self-measured plasma glucose target of 4-5 mmol/L. RESULTS:IDegAsp achieved the primary endpoint of non-inferiority to BIAsp 30 for mean change in HbA₁c (estimated treatment difference [ETD] IDegAsp-BIAsp 30: 0.05% points [95% CI -0.10; 0.20]). IDegAsp was superior in lowering fasting plasma glucose (FPG) (ETD -1.06 mmol/L, 95% CI -1.43; -0.70, p<0.001), and resulted in a lower final mean daily insulin dose (0.79 U/kg vs 0.99 U/kg, estimated rate ratio [RR] 0.79, 95% CI 0.73; 0.85, p<0.0001). Rates of overall confirmed and severe hypoglycaemia were similar between treatments, while rate of nocturnal confirmed hypoglycaemia was numerically (p=ns) lower with IDegAsp. During the maintenance period there was a trend (p=ns) towards lower hypoglycaemia rates for IDegAsp. CONCLUSION:In Asian adults with T2DM, IDegAsp BID effectively improves long-term glycaemic control, and compared to BIAsp 30, provides superior reductions in FPG with a lower dose, and numerically less nocturnal hypoglycaemia.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Kaneko S,Chow F,Choi DS,Taneda S,Hirao K,Park Y,Andersen TH,Gall MA,Christiansen JS,BOOST: Intensify All Trial Investigators.doi
10.1016/j.diabres.2014.09.026subject
Has Abstractpub_date
2015-01-01 00:00:00pages
139-47issue
1eissn
0168-8227issn
1872-8227pii
S0168-8227(14)00426-4journal_volume
107pub_type
杂志文章,多中心研究,随机对照试验abstract:AIM:To identify characteristics of neuropsychological function among elderly individuals with Type 2 diabetes mellitus with mild cognitive impairment (T2DM-MCI) and evaluate domain-specific effects of T2DM on cognition. METHODS:This was a cross-sectional study conducted in Tianjin, China. MCI subjects (n=246) and cont...
journal_title:Diabetes research and clinical practice
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abstract::High pressures on the soles of the feet of diabetic patients cause plantar ulcerations, and reduction of this pressure is important in the treatment and prevention of such ulcers. The effects of foot orthoses on the distribution of plantar pressures were investigated using a pressure-sensitive insole containing 960 se...
journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
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abstract::We examined the sex differences in the development of diabetes due to neonatal streptozotocin (STZ) treatment in spontaneously hypertensive rats (SHR) which are more prone to diabetes than normotensive rats. Male and female SHR were intraperitoneally injected with various doses of STZ at 2 days after birth. In those t...
journal_title:Diabetes research and clinical practice
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abstract:OBJECTIVE:Several genome-wide association studies and replication analyses have identified common variation at the insulin-like binding protein 2 (IGF2BP2) gene to be associated with type 2 diabetes (T2DM). The aim of this study was to replicate in a Lebanese Arab population identified associations of IGF2BP2 variants ...
journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
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abstract:AIMS:To investigate serum levels of thyroid stimulating hormone (TSH), anti-thyroid peroxidase antibody (TPO), and 25(OH)D in the presence or absence of metabolic syndrome in an obese population. METHODS:Data from a prospectively generated "Obesity Polyclinic" database that includes socio-demographic characteristics, ...
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journal_title:Diabetes research and clinical practice
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更新日期:2007-07-01 00:00:00
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journal_title:Diabetes research and clinical practice
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更新日期:2003-11-01 00:00:00
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更新日期:2013-10-01 00:00:00
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更新日期:2003-05-01 00:00:00
abstract:AIMS:To examine the association between habitual snoring and components of the metabolic syndrome in Korean adults. Whether these associations are independent of obesity was also explored. METHODS:Four thousand five hundred and six men and 5041 women aged 40-69 years from the Korean Health and Genome Study were examin...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,多中心研究
doi:10.1016/j.diabres.2005.06.011
更新日期:2006-03-01 00:00:00
abstract::The aim of this study was to examine distinctive clinical characteristics of non-insulin dependent diabetes mellitus (NIDDM) patients in Kuwait including mode of presentation at diagnosis, family history of diabetes, therapeutic management and response to treatment. We studied 3299 Kuwaiti patients (1454 male (M) and ...
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abstract::There are scant data from African populations on the association between beta-cell function and response to treatment with oral hypoglycaemic agents in Type 2 diabetes mellitus (T2DM). Fasting plasma C-peptide (FCP) and glucagon-stimulated C-peptide (GSCP) levels were measured in 116 Nigerians with T2DM at a universit...
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journal_title:Diabetes research and clinical practice
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更新日期:2000-10-01 00:00:00
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更新日期:2017-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-08-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2008.11.013
更新日期:2009-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,多中心研究
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更新日期:2015-04-01 00:00:00