Abstract：
OBJECTIVE:To investigate factors related to diabetic retinopathy (DR). METHOD:Clinical data of 603 Chinese diabetic patients were analyzed retrospectively. On the basis of its severity, DR was graded as non-diabetic retinopathy (NDR), non proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). Factor analysis was conducted and factor scores were used as independent variables in both Logistic and Ordinal regression models to identify the predictors of the development and/or progression of DR. RESULT:After factor analysis, 21 original variables were finally reduced to eight unique factors, representing obesity, glycemic, C peptide, lipids, time, renal, blood pressure and metabolic factors. Logistic regression revealed that female (OR = 2.208, 95%CI 1.328-3.671), comorbidity of peripheral atherosclerosis (PA) (OR = 2.690, 95%CI 1.000-7.238), time factor (OR = 1.838, 95%CI 1.421-2.377) and renal factor (OR = 2.444, 95%CI 1.757-3.400) were positively associated with DR, while C peptide factor (OR = 0.469, 95%CI 0.365-0.604) was negatively associated with DR. Besides another negatively related obesity factor (OR = 0.777), Ordinal regression revealed similarly related factors, but ruled out the influence of gender and PA. CONCLUSION:Female, macrovascular complications, time and renal factors are predictors of DR, while C peptide factor is negatively associated with the development and/or progression of DR.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Zheng Wdoi
10.1016/j.diabres.2011.02.007subject
Has Abstractpub_date
2011-05-01 00:00:00pages
244-52issue
2eissn
0168-8227issn
1872-8227pii
S0168-8227(11)00056-8journal_volume
92pub_type
杂志文章abstract：:The prevalence of increased urinary albumin excretion (UAE) (micro- and macroalbuminuria) and its association with diabetic retinopathy (DR) (evaluated by fluorescent angiography), coronary heart disease (CHD), and various related risk factors were studied in 320 type 2 diabetic patients. In this subsample of type 2 d...
journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0168-8227(98)00024-2
更新日期：1998-04-01 00:00:00
abstract：AIMS:Controlling food intake despite adequate knowledge remains a struggle for many people with type 2 diabetes. The present study investigated whether working memory training can reduce food intake and improve glycaemic control. It also examined training effects on cognition, food cravings, and dietary self-efficacy a...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.diabres.2018.07.005
更新日期：2018-09-01 00:00:00
abstract：AIMS:To examine the relationship of non-high-density lipoprotein cholesterol (non-HDL-C) level with cardiovascular disease (CVD) risk in type 2 diabetes patients and the general population by conducting a meta-analysis. METHODS:We made a comprehensive literature search for relevant observational studies investigating ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,meta分析
doi：10.1016/j.diabres.2018.11.002
更新日期：2019-01-01 00:00:00
abstract：AIM:Type 1 diabetes requires extensive self-management to avoid complications and may have negative effects on the everyday life of people with the disease. The aim of this study was to compare adults with type 1 diabetes to the general population in terms of health-related quality of life, occupational status (level o...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2016.08.021
更新日期：2016-11-01 00:00:00
abstract：:We evaluated the effects of thromboxane synthetase inhibitor, OKY-046, on urinary albumin and prostaglandin (PG) excretion in 14 patients with non-insulin-dependent diabetes mellitus (NIDDM). Urinary excretion of 6-keto-PGF1 alpha (a stable metabolite of PGI2), TXB2 (a stable metabolite of TXA2) and PGE2 in NIDDM pati...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(90)90066-3
更新日期：1990-11-01 00:00:00
abstract：:The usefulness of nocturnal penile tumescence (NPT) monitoring with stamps was evaluated in diabetic males with impotence. The stamps, which were similar in paper and size to Japanese 10-yen postage stamps, were wrapped around the penis before sleep and the stamp ring was checked for breakage the next morning. Clinica...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(88)80018-4
更新日期：1988-02-19 00:00:00
abstract：AIMS:To estimate and compare the prescription costs for the management of patients with diabetes over a period of 20 years in Greece, based on real world data. METHODS:The records of outpatients with T2D, monitored at three diabetes centres, were examined in four cross-sections (1998, 2006, 2012, 2018). Prescribed med...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108095
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVE:To investigate the changes of serum anti-aging protein Klotho and neutrophil gelatinase-associated lipocalin (NGAL) levels and their correlation in type 2 diabetes mellitus (T2DM) patients at different stages of diabetic kidney disease (DKD) determined by urinary albuminuria. METHODS:462 cases with T2DM were...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2014.08.026
更新日期：2014-11-01 00:00:00
abstract：:Sanguis draxonis (SD) is a Chinese traditional herb that is prescribed for the handling of diabetic disorders. In this study, the effects of an oral administration of SD at dosages of 100, 300, and 500 mg kg(-1) once a day, respectively, on the formation of insulin resistance were investigated in vivo in two models of...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2004.08.011
更新日期：2005-04-01 00:00:00
abstract：:Antidiabetic sulphonylureas have attracted a great deal of interest in experimental cardiology to evaluate the role of ATP-sensitive potassium channels in the cardiovascular system. It is well established that KATP channels are present in cardiac cells and also in vascular smooth muscle cells and are implicated in the...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/0168-8227(96)01229-6
更新日期：1996-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of specialized young adult diabetes clinic (YAC) on glycemic control in a young adult patients with type 1 diabetes (DM1) transitioning from pediatric to adult diabetes care. RESEARCH DESIGN AND METHODS:HbA1c was retrospectively analyzed through 3 years in 15-25 y/o DM1 patients enteri...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2007.04.014
更新日期：2007-12-01 00:00:00
abstract：:Hyperleptinemia, hypoadiponectinemia, and hyperresistinemia were found to be significantly higher with odds ratios (CI 95%) of 2.15, 2.05 and 3.05, respectively, among cigarette smokers with type 2 diabetes in Saudi Arabian population. Smoking cessation restored the adiponectin and leptin levels while having a modest ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2008.11.013
更新日期：2009-02-01 00:00:00
abstract：:This systematic review with meta-analysis examined whether lifestyle modification (diet and/or exercise) is effective for glycemic control in adults with type 2 diabetes in Southeast Asia. Results showed that lifestyle modification is effective in the short term (3months), but not over the longer term (6months) in thi...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.diabres.2016.10.008
更新日期：2016-12-01 00:00:00
abstract：AIM:Irisin is a new peptide produced mainly by the skeletal muscle playing an important role both in glucose/energy homeostasis and bone metabolism. Childhood type 1 diabetes mellitus (T1DM) is associated with decreased bone mass. We aimed to evaluate irisin levels in TD1M children and their correlation with bone metab...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2018.03.046
更新日期：2018-07-01 00:00:00
abstract：AIM:Sitagliptin is not associated with weight gain and has neutral effects on body weight. It is unclear whether sitagliptin treatment alters serum ghrelin levels in people with type 2 diabetes. METHODS:Forty-four subjects with type 2 diabetes were randomly assigned to receive sitagliptin or medical nutrition therapy ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabres.2011.07.031
更新日期：2011-11-01 00:00:00
abstract：AIM:We previously identified the transcription factor activating enhancer-binding protein-2beta (AP-2beta) gene as a new candidate for conferring susceptibility to type 2 diabetes. To ascertain the possible involvement of AP-2beta in the pathogenesis of type 2 diabetes we examined the effects of AP-2beta on glucose-ind...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2009.06.018
更新日期：2009-09-01 00:00:00
abstract：:To clarify the histological changes of the cardiac autonomic nervous system in diabetes mellitus, ganglionic cells of the hearts of autopsy cases were examined light microscopically. In 7 severely diabetic patients, the ganglionic neurons showed cellular contraction, cytoplasmic condensation and poor staining of Nissl...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(86)80014-6
更新日期：1986-06-01 00:00:00
abstract：:The aim of this study was to determine the 10-year mortality rate of an elderly population aged 70 years or over (n=379) with reference to glucose tolerance status, taking into account other determinants of excess mortality. The baseline examination during 1991-1992 included a postal questionnaire, a physical examinat...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2004.11.004
更新日期：2005-07-01 00:00:00
abstract：:The current study evaluates the indices of glucose control for diabetics (i.e., glycated albumin (GA), hemoglobin A1c (HbA1c), plasma glucose (PG) and immuno-reactive insulin (IRI)) in non-diabetic children from a population-based cohort, and compares those values according to the presence of obesity to examine any di...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2005.07.008
更新日期：2006-03-01 00:00:00
abstract：AIMS:Amounts of macrophages were infiltrated in glomeruli in diabetic nephropathy. Heparanase has been thought to be closely related to proteinuria. Our aims were to determine the effect of heparanase on the inflammation in AGEs-stimulated macrophages and its role on the functions of glomerular endothelial cells (GEnCs...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2016.12.016
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVE:To test the association of undiagnosed Type 2 diabetes mellitus with education and income level. METHODS:We utilized measures of diabetes status, fasting plasma glucose, socio-economic status, and demographic characteristics from the National Health and Nutrition Examination Survey (NHANES III) for adults of...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2005.02.008
更新日期：2005-10-01 00:00:00
abstract：AIMS:The current study sought to identify patient-level factors related to health care use among White and minority men and women with diabetes. METHODS:A sample of 447 of non-pregnant individuals with diabetes, ages 18-64, was drawn from the 2015-2016 National Health and Nutrition Examination Surveys dataset. Poisson...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2019.03.001
更新日期：2019-04-01 00:00:00
abstract：:C57BL/KsJ mice carrying homozygous db/db mutation (db/db mice) are characterized by extreme obesity and early onset of hyperglycemia. In an attempt to rectify diabetes of these mice, a pancreatic beta cell line MIN6, which retains glucose-inducible insulin secretion, was transplanted subcutaneously into the back of th...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(96)01249-1
更新日期：1996-05-01 00:00:00
abstract：:We investigated whether isoprostanes, as a marker of lipid peroxidation, may be involved in the development of impaired glucose tolerance (IGT) or diabetes. Using a nested case-control study, we tracked the changes in isoprostane levels, insulin sensitivity (IS) and beta-cell function (BCF) in Afro-Jamaicans who progr...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2006.08.003
更新日期：2007-04-01 00:00:00
abstract：AIM:To examine patient formation of implementation plans, a volitional strategy, and its influence on self-monitoring of blood glucose (SMBG). METHODS:A randomized experimental-control design over a 2-week time period was used. The study population was diabetes patients with HbA1c >7% and requiring insulin therapy. Pa...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabres.2010.03.011
更新日期：2010-07-01 00:00:00
abstract：:Diabetes mellitus is associated with increased frequency, severity and more rapid progression of cardiovascular diseases. Metabolic perturbations from hyperglycemia result in disturbed endothelium-dependent relaxation, activation of coagulation pathways, depressed fibrinolysis, and other abnormalities in vascular home...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/s0168-8227(99)00036-4
更新日期：1999-09-01 00:00:00
abstract：:Aminoguanidine, an inhibitor of advanced glycation reactions in vitro, inhibits the development of diabetic complications in animal models of diabetes, suggesting that it acts by inhibition of advanced glycation reactions in vivo. However, effects of aminoguanidine on the formation of specific advanced glycation end-p...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(98)00121-1
更新日期：1999-02-01 00:00:00
abstract：:A retrospective analysis of blood glucose control was performed in 17 type 1 diabetic patients who regularly monitored their blood glucose concentration by visual strips over a period of 3-83 months. Analysis was performed by a patient management software loaded on a personal computer. In this cohort of patients the a...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(92)90117-a
更新日期：1992-06-01 00:00:00
abstract：:Epidemiologic studies of migrant populations provide very promising clues towards understanding the roles of genetics and environmental factors in the etiology of diabetes mellitus. Populations of Japanese ancestry are of particular interest due to marked differences in prevalence rates of non-insulin dependent diabet...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：UNLABELLED:Over 1 year, a survey on contraception and obstetric history was performed on a cohort of 667 Caucasian fertile diabetic women (446, type 1 and 201, type 2) living in Italy. RESULTS:Of these women, 30.4% used hormonal contraceptives, 12.0% intra-uterine device (IUD), 10.7% declared they used no contraceptio...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2004.07.020
更新日期：2005-03-01 00:00:00
