Abstract:
:The Japan Diabetes Society (JDS) conducted a multicenter study on the immunogenetics of insulin-dependent diabetes mellitus (IDDM) among Japanese. The previous report of the JDS study described HLA types and other immunogenetic markers in Japanese patients with IDDM. In the present report, the autoimmunity of Japanese patients was studied by measuring ICA and other organ-specific autoantibodies in patients with different durations of IDDM. The prevalences of ICA were the highest in the first year after diagnosis (73.1%) and decreased to 58.0%, 18.3% and 2.8% in 1-5 years, 5-10 years and 10 years or more after diagnosis, respectively (P < 0.01), while the prevalences of the other organ specific autoantibodies increased gradually with duration of IDDM from 20% in the first year to 35% in 10 years or more after diagnosis (P < 0.05). There were no sex differences in the prevalences of ICA but those of other organ-specific autoantibodies were significantly higher in female patients than in male patients (P < 0.01). The prevalence of ICA was not correlated with sex, age at onset or HLA types. In one of the subjects, a girl, the titers of ICA increased in parallel with a decrease in insulin secretion before the development of overt IDDM and declined thereafter. These findings suggest that IDDM might develop when the autoimmunity specific to pancreatic islets is triggered in people with underlying autoimmunity as shown by the presence of organ-specific autoantibodies other than ICA.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Kida K,Mimura G,Kobayashi T,Matsuura N,Toyota T,Kitagawa T,Hibi I,Ikeda Y,Tuchida I,Kuzuya Hdoi
10.1016/0168-8227(94)90104-xsubject
Has Abstract,Author List Incompletepub_date
1994-04-01 00:00:00pages
187-93issue
3eissn
0168-8227issn
1872-8227pii
0168-8227(94)90104-Xjournal_volume
23pub_type
杂志文章abstract::Insulin release is influenced by the autonomic nervous system. Regarding parasympathetic control, previous reports have shown that regulation of insulin release is executed exclusively through muscarinic receptors in the pancreatic islets. In the present study, however, we examined the effect on insulin release at the...
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,多中心研究
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更新日期:2010-03-01 00:00:00
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journal_title:Diabetes research and clinical practice
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doi:10.1016/j.diabres.2009.07.001
更新日期:2009-09-01 00:00:00
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journal_title:Diabetes research and clinical practice
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更新日期:2004-10-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,多中心研究
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1016/j.diabres.2016.11.026
更新日期:2017-02-01 00:00:00
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doi:10.1016/s0168-8227(86)80037-7
更新日期:1985-01-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/0168-8227(95)01119-x
更新日期:1995-07-01 00:00:00
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journal_title:Diabetes research and clinical practice
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doi:10.1016/j.diabres.2017.09.009
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-02-01 00:00:00
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更新日期:2008-11-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-12-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2004.04.001
更新日期:2004-12-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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更新日期:1999-06-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2014.12.014
更新日期:2015-03-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/0168-8227(92)90083-4
更新日期:1992-05-01 00:00:00
abstract::The insulin sensitivity of intermediary metabolism was studied in 8 non-obese men with well-controlled diet-treated non-insulin dependent diabetes (NIDDM) using a low dose incremental insulin infusion (basal, 0.005 and 0.01 U/kg h-1). Results were compared to 8 healthy male control subjects matched (NIDDM vs. controls...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/0168-8227(93)90023-x
更新日期:1993-04-01 00:00:00
abstract:AIMS:An appropriate questionnaire for assessing family support of self-management behavior of Japanese Type 2 diabetes patients has yet to be developed. We produced a Japanese version of the Diabetes Family Behavior Checklist (DFBC) and tested its reliability and validity. METHODS:The study enrolled Japanese patients ...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2012.10.014
更新日期:2013-01-01 00:00:00