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Possible involvement of cholinergic nicotinic receptor in insulin release from isolated rat islets.

Abstract：

:Insulin release is influenced by the autonomic nervous system. Regarding parasympathetic control, previous reports have shown that regulation of insulin release is executed exclusively through muscarinic receptors in the pancreatic islets. In the present study, however, we examined the effect on insulin release at the islet level of various agents affecting the parasympathetic nervous system, especially nicotinic receptor blockers. Pancreatic islets isolated from adult Wistar male rats were incubated with these agents and insulin release in the media was measured. Acetylcholine chloride (10(-5) M), as well as distigmine bromide (10(-6), 10(-5) M), both of which are cholinesterase inhibitors, stimulated insulin release, whereas atropine (5 x 10(-6), 5 x 10(-5) M) suppressed it. On the other hand, serum and IgG from myasthenia gravis patients, containing anti-acetylcholine receptor antibodies, affected insulin release, and alpha-bungarotoxin (10(-9)-10(-7) M), a nicotinic receptor blocker, stimulated insulin release dose-dependently. The present observations suggest that insulin release is influenced by the parasympathetic nervous system, mediated via not only muscarinic but also nicotinic receptors.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Ejiri K,Taniguchi H,Ishihara K,Hara Y,Baba S

doi

10.1016/0168-8227(90)90117-c

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

193-9

issue

3

eissn

0168-8227

issn

1872-8227

pii

0168-8227(90)90117-C

journal_volume

8

pub_type

杂志文章

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