Abstract：
AIM:The study aims to investigate the gene expression profiling of insulin signaling pathway and mitochondrial biogenesis and function in the skeletal muscle of KK mice. METHODS:KK mice were divided into the following groups: KK control group, basal medium (M199) only; KK fibroblast group, with human fibroblast transplantation; KK myoblast group, with human skeletal myoblast transplantation. C57BL mice received hSkM transplantation as a normal control. Cells were transplanted into mice hind limb skeletal muscle. All animals were treated with cyclosporine for 6 weeks only. The mice were sacrificed in a fasting state at 12 weeks after treatment. Hind limb skeletal muscle was harvested and used for study of gene expression profiling. RESULTS:hSkMs survived extensively in mice skeletal muscle at 12 weeks after cell transplantation. Glucose tolerance test showed a significant decrease of blood glucose in the mice of KK myoblast group compared to the KK control and fibroblast groups. Transcriptional patterns of insulin signaling pathway showed alterations in KK myoblast as compared with KK control group (23 genes), KK fibroblast group (7 genes), and C57BL group (8 genes). Transcriptional patterns of mitochondrial biogenesis and function also had alterations in KK myoblast as compared with KK control group (27 genes), KK fibroblast group (9 genes), and C57BL group (6 genes). CONCLUSIONS:These data demonstrated for the first time that hSKM transplantation resulted in a change of gene transcript in multiple genes involved in insulin signaling pathway and mitochondrial biogenesis and function.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Ma JH,Su LP,Zhu J,Law PK,Lee KO,Ye L,Wang ZZdoi
10.1016/j.diabres.2013.08.006subject
Has Abstractpub_date
2013-10-01 00:00:00pages
43-52issue
1eissn
0168-8227issn
1872-8227pii
S0168-8227(13)00295-7journal_volume
102pub_type
杂志文章abstract：AIMS:To assess the relationship between patient activation for self-management and admissions to hospital or attendances at emergency departments among people with diabetes, after controlling for other known associations. METHODS:Patients were randomly selected from Australia's National Diabetes Services Scheme and in...
journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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更新日期：1992-04-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2007.01.070
更新日期：2007-09-01 00:00:00
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Diabetes research and clinical practice
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更新日期：2004-12-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：2018-07-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：2010-11-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：2020-11-21 00:00:00
abstract：AIMS:To determine which barriers to care are associated with type 2 diabetes complications in an area in rural East England. METHODS:3649 individuals with type 2 diabetes from 62 general practices were contacted via postal invitation which included a 33 item Barriers-to-Diabetes-Care Survey. Barriers were grouped into...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2018.04.031
更新日期：2018-07-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：2014-06-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2012.12.007
更新日期：2013-03-01 00:00:00
abstract：:The impact of hypertension, overall obesity and abdominal obesity, individually or collectively, on diabetes incidence over a period of 5 years in residents with different glucose levels is diverse, with abdominal obesity having an impact in both non-diabetic hyperglycaemia and normal groups. ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2011.08.018
更新日期：2012-06-01 00:00:00
abstract：AIMS:Infrared thermal imaging (IR) is not yet routinely implemented for early detection of diabetic foot ulcers (DFU), despite proven clinical effectiveness. Low-cost, smartphone-based IR-cameras are now available and may lower the threshold for implementation, but the quality of these cameras is unknown. We aim to val...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2019.01.032
更新日期：2019-03-01 00:00:00
abstract：:Chronic renal diseases, including diabetic nephropathy, evolve to terminal renal failure by a process leading to progressive parenchimal damage which appears relatively independent of the initial insult. When glomerular permselectivity is lost, proteins filtered through the glomerular capillary, through proximal tubul...
journal_title：Diabetes research and clinical practice
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doi：10.1016/s0168-8227(98)00016-3
更新日期：1998-04-01 00:00:00
