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Risk factors associated with the progression of COVID-19 in elderly diabetes patients.

Abstract：

AIM:To describe the clinical characteristics and risk factors associated with the progression of COVID-19 in elderly diabetes patients. METHODS:This was a retrospective cohort study, including elderly COVID-19 patients admitted to Wuhan Huoshenshan Hospital between February 10 and 13, 2020. Demographic data, medical history, signs and symptoms, and laboratory parameters were collected and analysed. RESULTS:We included 131 elderly COVID-19 patients (50 patients with diabetes). COVID-19 diabetes patients experienced more severe pneumonia and abnormal organ functions than non-diabetes patients (P < 0.05 or P < 0.01). Most function indicators were significantly different between the mild to moderate and severely ill groups in diabetes patients (P < 0.05 or P < 0.01). Python analysis confirmed diabetes was the independent risk factor of COVID-19 progression in elderly patients. All blood glucose (BG) indices went into the risk factor equation. The cut-off values of COVID-19 progression were BG value on admission > 8.0 mmol/L or maximum BG value > 12.0 mmol/L in all elderly patients, and BG value on admission > 5.1 mmol/L or maximum BG value > 5.4 mmol/L in non-diabetes patients. CONCLUSIONS:Diabetes is an independent important risk factor, and glucose levels associate closely with COVID-19 progression in elderly patients.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Zhang P,Wang M,Wang Y,Wang Y,Li T,Zeng J,Wang L,Li C,Gong Y

doi

10.1016/j.diabres.2020.108550

subject

Has Abstract

pub_date

2020-11-21 00:00:00

pages

108550

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(20)30807-X

journal_volume

171

pub_type

杂志文章

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