当前位置： SCI文献检索 > DIABETES RESEARCH AND CLINICAL PRACTICE期刊下所有文献 > HLA-DQB1 genotypes and islet cell autoantibodies against GAD65 and IA-2 in relation to development of diabetes post partum in women with gestational diabetes mellitus.

HLA-DQB1 genotypes and islet cell autoantibodies against GAD65 and IA-2 in relation to development of diabetes post partum in women with gestational diabetes mellitus.

Abstract：

AIMS:To study HLA-DQB1 genes and islet cell autoantibodies against glutamic acid decarboxylase 65 (GADA) and insulinoma antigen-2 (IA-2A) in relation to diabetes post partum in mothers with diagnosed gestational diabetes mellitus (GDM). METHODS:During 2003-2004, women undergoing a 75 g oral glucose tolerance test (OGTT) during pregnancy were invited to participate in the Mamma Study. Cut-off level defining GDM was a 2-h capillary blood glucose of 7.8 mmol/L. 1-2 years after delivery a 75 g OGTT was performed, GADA and IA-2A were measured and HLA-DQB1 genes analysed. Data were available for 452 mothers with previous GDM and 168 randomly selected control subjects. RESULTS:HLA-DQB1*0602 was negatively associated with GDM (p=0.033) and with development of diabetes post partum (p=0.017), whereas high risk HLA were not associated with GDM or with diabetes. The presence of GADA post partum was positively associated with diabetes post partum (p=0.0009), but not with impaired glucose tolerance. CONCLUSIONS:Mothers with GDM and HLA-DQB1*0602 were less likely to develop diabetes after pregnancy, and type 1 diabetes associated high risk HLA genes did not predict type 1 diabetes post partum. Additionally, GADA were positively associated with diabetes development.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Papadopoulou A,Lynch KF,Anderberg E,Landin-Olsson M,Hansson I,Agardh CD,Lernmark Å,Berntorp K

doi

10.1016/j.diabres.2011.10.037

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

260-4

issue

2

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(11)00600-0

journal_volume

95

pub_type

杂志文章

相关文献

DIABETES RESEARCH AND CLINICAL PRACTICE文献大全
  • Time-course changes in clinical features of early-onset Japanese type 1 and type 2 diabetes: TWMU hospital-based study.

    abstract：:Using a database of patients with type 1 (n=1675) and type 2 (n=2259) diabetes diagnosed before the age of 30 years at the Diabetes Center, Tokyo Women's Medical University (TWMU), in which such Japanese patients have been registered at the time of first visit since the 1960s, we performed a hospital-based study over ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2008.06.021

    authors： Uchigata Y,Otani T,Takaike H,Miura J,Osawa M,Tukahara S,Kasahara T,Iwamoto Y

    更新日期：2008-10-01 00:00:00

  • Metabolic response 4 years after gastric bypass in a complete cohort with type 2 diabetes mellitus.

    abstract：AIMS:To evaluate the long-term remission rates of type 2 diabetes mellitus and associated comorbidities after gastric bypass surgery in a complete cohort, in a real-life clinic setting. METHODS:A retrospective study of all consecutive patients with type 2 diabetes mellitus who underwent gastric bypass at a Veterans Af...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2017.11.022

    authors： Carranza-Leon BG,Puzziferri N,Adams-Huet B,Jabbour I,Lingvay I

    更新日期：2018-03-01 00:00:00

  • Microalbuminuria and associated clinical features among Brazilians with insulin dependent diabetes mellitus.

    abstract：:With the objective to determine the frequency of microalbuminuria, macroalbuminuria and the associated clinic and metabolic features among insulin dependent diabetes mellitus (IDDM) Brazilian patients attending at a general University Hospital, a total of 50 outpatients, aged 21.9 +/- 7 years with IDDM duration of 6.8...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(97)01368-5

    authors： Gomes MB,Lucchetti MR,Gazzola H,Dimetz T,Gonçalves MF,Neves R,Matos H

    更新日期：1997-03-01 00:00:00

  • Cardio vascular morbidity in proteinuric south Indian NIDDM patients.

    abstract：:Proteinuria is a well known risk factor for cardiovascular morbidity. There has been no report on cardiovascular morbidity in Indian NIDDM patients with proteinuria. Hence this study has been undertaken to estimate the prevalence of cardiovascular diseases (CVD) in South Indian NIDDM with proteinuria. We studied two g...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(97)00107-1

    authors： Viswanatham V,Snehalatha C,Mathai T,Jayaraman M,Ramachandran A

    更新日期：1998-01-01 00:00:00

  • Different effects of growth hormone on growth and function of isolated adult and fetal rat pancreatic islets.

    abstract：:We simultaneously determined 3H-thymidine incorporation, DNA content, and insulin biosynthesis in adult and fetal rat pancreatic islets. 3H-thymidine incorporation was measured after tissue solubilization. DNA was measured fluorometrically. Insulin biosynthesis was determined through 3H-leucine incorporation after imm...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(88)80053-6

    authors： Sieradzki J,Chatterjee AK,Fleck E,Schatz H

    更新日期：1988-07-13 00:00:00

  • Association of diabetes mellitus with myocardial collagen accumulation and relaxation impairment in patients with dilated cardiomyopathy.

    abstract：AIMS:To assess the effects of diabetes mellitus (DM) on myocardial collagen accumulation, myocardial relaxation, and prognosis in patients with dilated cardiomyopathy (DCM). METHODS:A total of 102 consecutive DCM patients with a New York Heart Association functional class of I or II were enrolled. Patients were alloca...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2011.02.023

    authors： Sakakibara M,Hirashiki A,Cheng XW,Bando Y,Ohshima K,Okumura T,Funahashi H,Ohshima S,Murohara T

    更新日期：2011-06-01 00:00:00

  • Self-monitoring of blood glucose in type 2 diabetes: an inter-country comparison.

    abstract：:Self-monitoring of blood glucose (SMBG) in type 2 diabetic patients was compared across 14 countries. There was an unexpectedly high SMBG-use in non-insulin-treated patients. Reimbursement polices differed by country, region, insurance status, and patient income. More rigorous and systematic data collection is needed ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2008.08.021

    authors： SMBG International Working Group.

    更新日期：2008-12-01 00:00:00

  • Short-term aerobic exercise improves arterial stiffness in type 2 diabetes.

    abstract：OBJECTIVE:To investigate whether: (1) aerobic exercise decreases arterial stiffness and (2) reduction in arterial stiffness is associated with improvement in insulin resistance in type 2 diabetes. METHODS:Common carotid and femoral arterial stiffness was ultrasonographically evaluated using stiffness index beta in 23 ...

    journal_title：Diabetes research and clinical practice

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.diabres.2003.12.005

    authors： Yokoyama H,Emoto M,Fujiwara S,Motoyama K,Morioka T,Koyama H,Shoji T,Inaba M,Nishizawa Y

    更新日期：2004-08-01 00:00:00

  • Plasma retinol-binding protein is unlikely to be a useful marker of insulin resistance.

    abstract：:To assess whether plasma retinol-binding protein (RBP) is a marker of insulin resistance we measured RBP, insulin and glucose in 285 fasting subjects attending a Lipid Disorders Clinic as outpatients. They were grouped as either subjects without diabetes mellitus and with varying degrees of insulin resistance or subje...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2007.12.002

    authors： Lewis JG,Shand BI,Elder PA,Scott RS

    更新日期：2008-04-01 00:00:00

  • Increased serum pigment epithelium-derived factor levels in type 1 diabetic patients with diabetic retinopathy.

    abstract：:Serum pigment epithelium-derived factor (PEDF) levels were significantly higher in type 1 diabetic patients with retinopathy (n=20, 10.38+/-3.87 microg/ml) compared to the patients without it (n=57, 7.68+/-2.80 microg/ml) (p=0.0013). Elevated PEDF levels may be related to the progression of diabetic retinopathy. ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2008.03.009

    authors： Katakami N,Kaneto H,Yamasaki Y,Matsuhisa M

    更新日期：2008-07-01 00:00:00

  • A novel imaging platform for non-invasive screening of abnormal glucose tolerance.

    abstract：:Optical measurement of skin auto-fluorescence (SAF), most likely emanating from accumulated advanced glycation end-products (AGEs), has been proposed for the noninvasive diagnosis of glucose intolerance in clinical settings. Here, we developed a novel imaging system with transmission geometry for SAF measurement and c...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2016.03.014

    authors： Jeong B,Jung CH,Lee YH,Shin IH,Kim H,Bae SJ,Lee DS,Kang ES,Kang U,Kim JJ,Park JY

    更新日期：2016-06-01 00:00:00

  • The modulating effects of the overexpression of uncoupling protein 2 on the formation of reactive oxygen species in vascular cells.

    abstract：:Uncoupling protein 2 (UCP-2) is a newly identified member of the mitochondrial anion carrier family and shares 60% sequence identity with the well-characterized thermogenic UCP-1 from brown adipose tissue. Several lines of evidence suggest that UCP-2 is involved in the control of reactive oxygen species (ROS) producti...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2007.01.032

    authors： Kim HS,Park KG,Koo TB,Huh S,Lee IK

    更新日期：2007-09-01 00:00:00

  • Diabetes care targets in older persons.

    abstract：:The increasing proportions of older persons accounting for global populations, and the implications for increasing rates of chronic diseases such as type 2 diabetes mellitus, continue to be a cause of concern for clinicians. Considering that older persons are a very heterogeneous group of individuals, the management o...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/S0168-8227(09)70007-5

    authors： Abbatecola AM,Paolisso G

    更新日期：2009-12-01 00:00:00

  • Abnormal transient rise in hepatic glucose production after oral glucose in non-insulin-dependent diabetic subjects.

    abstract：:A transient rise in hepatic glucose production (HGP) after an oral glucosa load has been reported in some insulin-resistant states such as in obese fa/fa Zucker rats. The aim of this study was to determine whether this rise in HGP also occurs in subjects with established non-insulin-dependent diabetes mellitus (NIDDM)...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(95)01067-n

    authors： Thorburn A,Litchfield A,Fabris S,Proietto J

    更新日期：1995-05-01 00:00:00

  • Diabetes in the Melanesian and Indian peoples of Fiji: a study of risk factors.

    abstract：:Epidemiological risk factor patterns for diabetes mellitus determined by hemoglobin A1 and fasting blood glucose criteria were compared in the biethnic (Melanesian and Indian) nation of Fiji. The 2 diagnostic criteria elicited essentially similar risk factor patterns in Indians but ranking of predictors was altered in...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(87)80050-5

    authors： Hoskins PL,Handelsman DJ,Hannelly T,Silink M,Yue DK,Turtle JR

    更新日期：1987-09-01 00:00:00

  • Continuous subcutaneous insulin infusion does not correspond with pregnancy outcomes despite better glycemic control as compared to multiple daily injections in type 1 diabetes - Significance of pregnancy planning and prepregnancy HbA1c.

    abstract：OBJECTIVE:The aim of the study was to compare pregnancy outcomes with glycemic control, total increase in insulin requirement, and body weight gain in the women with Type 1 Diabetes Mellitus (T1DM) using continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDI). MATERIAL AND METHODS:This was a...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108628

    authors： Żurawska-Kliś M,Kosiński M,Kuchnicka A,Rurka M,Hałucha J,Wójcik M,Cypryk K

    更新日期：2020-12-22 00:00:00

  • Decrease in plasma GLP-1 immunoreactivity in starved rats.

    abstract：:To determine whether starvation affects the metabolism of glucagon-like peptide-1 (GLP-1), we measured the plasma levels of proglucagon-derived peptides and the biosynthesis and posttranslational processing of proglucagon in groups of six rats starved for 1, 3 and 5 days. The plasma levels of GLP-1 immunoreactivity (G...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(92)90026-n

    authors： Takahashi J,Noma Y,Yoshimoto S,Fujita C,Shima K

    更新日期：1992-03-01 00:00:00

  • Using insulin pen needles up to five times does not affect needle tip shape nor increase pain intensity.

    abstract：AIMS:Reusing insulin pen needles could help to reduce the increasing economic burden of diabetes. We tested the hypothesis that reusing insulin pen needles leads to needle tip deformity and increased pain. METHODS:Three blinded reviewers assessed 123 electron microscope pictures analyzing needle tip deformity of insul...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2004.06.001

    authors： Puder JJ,Atar M,Muller B,Pavan M,Keller U

    更新日期：2005-02-01 00:00:00

  • Recurrence of gestational diabetes mellitus: rates and risk factors from initial GDM and one abnormal GTT value.

    abstract：:The recurrence rate of GDM among women in Japan who had GDM or one abnormal value on 75 g oral glucose tolerance test (OAV) during an initial pregnancy is unclear. We therefore sought to determine the recurrence rate and risk factors of recurrent GDM by evaluating 32 patients with GDM and 37 with OAV in their index pr...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2005.05.011

    authors： Nohira T,Kim S,Nakai H,Okabe K,Nohira T,Yoneyama K

    更新日期：2006-01-01 00:00:00

  • Role of vascular reactive oxygen species in development of vascular abnormalities in diabetes.

    abstract：:Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in patients with diabetes. Oxidative stress has been postulated to be a major contributor to the pathogenesis of these events. There is considerable evidence that many biochemical pathways adversely affected by hyper...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabres.2007.01.036

    authors： Son SM

    更新日期：2007-09-01 00:00:00

  • Glucagon-like peptide-1 (7-36 amide): a potent glucagonostatic and insulinotropic hormone.

    abstract：:Glucagon-like peptide-1 (GLP-1) (1-37) and the fraction derived from it, GLP-1 (7-36 amide), are peptides encoded by the preproglucagon gene and possibly co-secreted with enteroglucagon. When added at a 25-nM concentration, GLP-1 (7-36 amide) decreased the release of glucagon from the perfused rat pancreas from 68.5 +...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(88)80063-9

    authors： Matsuyama T,Komatsu R,Namba M,Watanabe N,Itoh H,Tarui S

    更新日期：1988-10-14 00:00:00

  • A community-based study for the utility values associated with diabetic retinopathy among type 2 diabetics in Kinmen, Taiwan.

    abstract：:A community-based cross-sectional study was conducted to assess the utility values associated with varying degrees of diabetic retinopathy (DR) among type 2 diabetics in Kinmen, Taiwan. A total of 725 eligible type 2 diabetics received DR screening during 1999-2002 and then evaluated utility values in 2003. The diagno...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2004.10.003

    authors： Tung TH,Chen SJ,Lee FL,Liu JH,Lin CH,Chou P

    更新日期：2005-06-01 00:00:00

  • Prevalence of undiagnosed diabetes mellitus and cardiovascular risk factors in Hong Kong professional drivers.

    abstract：AIMS:To investigate the prevalence of undiagnosed diabetes mellitus (DM) and cardiovascular risk factors among professional drivers in Hong Kong. METHODS:Chinese professional drivers with no history of DM were invited to complete a questionnaire on their health status, followed by taking their body measurements, fasti...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2011.12.002

    authors： Siu SC,Wong KW,Lee KF,Lo YY,Wong CK,Chan AK,Fong DY,Lam CL

    更新日期：2012-04-01 00:00:00

  • A patient with diabetes mellitus, cardiomyopathy, and a mitochondrial gene mutation: confirmation of a gene mutation in cardiac muscle.

    abstract：:A 44-year-old woman with diabetes mellitus, cardiomyopathy, and a mitochondrial gene mutation, was reported. She was diagnosed as having diabetes at 33 years of age and was treated with insulin. However, she stopped treatment 6 months later and had no medical care until she developed diabetic ketoacidosis at 41 years ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(95)01100-r

    authors： Kitaoka H,Kameoka K,Suzuki Y,Sasaki E,Majima M,Takada K,Katagiri H,Oka Y,Ohsawa N

    更新日期：1995-06-01 00:00:00

  • Glucose transporter levels in a male spontaneous non-insulin-dependent diabetes mellitus rat of the Otsuka Long-Evans Tokushima Fatty strain.

    abstract：:Otsuka Long-Evans Tokushima Fatty (OLETF) rats are a new strain of spontaneous non-insulin-dependent diabetes mellitus (NIDDM) models. To evaluate the role of glucose transporters (GLUT) in the development of diabetes in this model, we examined the action of insulin on the translocation of GLUT4 and GLUT1 in isolated ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(97)00101-0

    authors： Toide K,Man ZW,Asahi Y,Sato T,Nakayama N,Noma Y,Oka Y,Shima K

    更新日期：1997-12-01 00:00:00

  • Association between alcohol intake amount and prevalence of metabolic syndrome in Korean rural male population.

    abstract：:Moderate alcohol consumption is known to be associated with a reduced risk of cardiovascular disease and mortality. However, few studies reported that long-term alcohol drinking may increase the prevalence of central obesity, and cardiovascular disease. We examined the association between metabolic syndrome, nutrition...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2010.01.009

    authors： Lee MY,Kim MY,Kim SY,Kim JH,Kim BH,Shin JY,Shin YG,Yun JH,Ryu SY,Lee TY,Koh SB,Chung CH

    更新日期：2010-05-01 00:00:00

  • Beta cell function and response to treatment in Nigerians with Type 2 diabetes mellitus.

    abstract：:There are scant data from African populations on the association between beta-cell function and response to treatment with oral hypoglycaemic agents in Type 2 diabetes mellitus (T2DM). Fasting plasma C-peptide (FCP) and glucagon-stimulated C-peptide (GSCP) levels were measured in 116 Nigerians with T2DM at a universit...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2004.12.006

    authors： Oli JM,Adeyemo AA,Okafor GO,Ofoegbu EN,Onyenekwe B,Chukwuka CJ,Chen G,Chen Y,Doumatey AP,Aje TO,Rotimi CN

    更新日期：2005-08-01 00:00:00

  • Serum insulin is a risk marker for coronary heart disease mortality in men but not in women.

    abstract：:Serum insulin 1 h post-glucose load is examined in this prospective study of 2971 Caucasoid subjects aged > 20 years in 1966 and followed to 1989. The serum insulin levels as a continuous variable show no significant linear association with coronary heart disease (CHD) deaths in either sex after accounting for age by ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(94)90139-2

    authors： Welborn TA,Knuiman MW,Ward N,Whittall DE

    更新日期：1994-11-01 00:00:00

  • C-reactive protein and the risk of developing type 2 diabetes in Aboriginal Australians.

    abstract：OBJECTIVE:To investigate the association between C-reactive protein (CRP) and the risk of developing diabetes in Aboriginal Australians. RESEARCH DESIGN AND METHODS:High sensitivity CRP levels were measured in 620 Aboriginal participants aged 20-74 years free from diabetes at baseline in a remote community in the Nort...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2006.07.018

    authors： Wang Z,Hoy WE

    更新日期：2007-04-01 00:00:00

  • Low prevalence of MODY2 and MODY3 mutations in Brazilian individuals with clinical MODY phenotype.

    abstract：:Prevalence of MODY2 and MODY3 mutations has been assessed in 23 Brazilian families with MODY phenotype. Mutations in HNF-1alpha have been found in 3 families (13%) and 2 families (8.7%) had new glucokinase mutations. These genes do not explain the majority of MODY cases in Brazilian population. ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2008.06.011

    authors： Furuzawa GK,Giuffrida FM,Oliveira CS,Chacra AR,Dib SA,Reis AF

    更新日期：2008-09-01 00:00:00