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Association of diabetes mellitus with myocardial collagen accumulation and relaxation impairment in patients with dilated cardiomyopathy.

Abstract：

AIMS:To assess the effects of diabetes mellitus (DM) on myocardial collagen accumulation, myocardial relaxation, and prognosis in patients with dilated cardiomyopathy (DCM). METHODS:A total of 102 consecutive DCM patients with a New York Heart Association functional class of I or II were enrolled. Patients were allocated to two groups on the basis of the presence (DCM+DM group, n = 30) or absence (DCM-DM group, n = 72) of DM. Cardiac catheterization performed and left ventricular pressure were measured in all patients. The pressure half-time (T(1/2)) was determined as an index of myocardial relaxation function. Endomyocardial specimens were subjected to histological analysis. RESULTS:The T(1/2) was significantly longer (P < 0.001) and the collagen volume fraction was significantly greater (P = 0.018) in the DCM + DM group than in the DCM-DM group. Multivariate analysis showed that DM was significantly associated with increased incidence of cardiac events (hazard ratio, 3.7; 95% confidence interval, 1.05 to 13.16; P = 0.03). CONCLUSIONS:The prognosis of DCM patients with DM was worse than that of those without DM. Impairment of myocardial relaxation, increased myocardial fibrosis, and mitochondrial degeneration associated with DM may underlie this difference.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Sakakibara M,Hirashiki A,Cheng XW,Bando Y,Ohshima K,Okumura T,Funahashi H,Ohshima S,Murohara T

doi

10.1016/j.diabres.2011.02.023

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

348-55

issue

3

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(11)00100-8

journal_volume

92

pub_type

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