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Different effects of growth hormone on growth and function of isolated adult and fetal rat pancreatic islets.

Abstract：

:We simultaneously determined 3H-thymidine incorporation, DNA content, and insulin biosynthesis in adult and fetal rat pancreatic islets. 3H-thymidine incorporation was measured after tissue solubilization. DNA was measured fluorometrically. Insulin biosynthesis was determined through 3H-leucine incorporation after immunoprecipitation and binding to protein A-sepharose. Addition of growth hormone caused a significant increase in 3H-thymidine incorporation into both the adult and the fetal islets, but only the adult islets experienced an increase in DNA content. The increase in 3H-leucine incorporation was also significant only in the adult islets. The dynamics of 3H-thymidine incorporation after growth hormone administration were different in the adult and the fetal pancreas. Fetal islets have the potential to increase their incorporation of 3H-thymidine, but very limited potential for insulin biosynthesis.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Sieradzki J,Chatterjee AK,Fleck E,Schatz H

doi

10.1016/s0168-8227(88)80053-6

subject

Has Abstract

pub_date

1988-07-13 00:00:00

pages

145-51

issue

2

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(88)80053-6

journal_volume

5

pub_type

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