Time-course changes in clinical features of early-onset Japanese type 1 and type 2 diabetes: TWMU hospital-based study.

Abstract:

:Using a database of patients with type 1 (n=1675) and type 2 (n=2259) diabetes diagnosed before the age of 30 years at the Diabetes Center, Tokyo Women's Medical University (TWMU), in which such Japanese patients have been registered at the time of first visit since the 1960s, we performed a hospital-based study over the last 40 years to clarify time-course changes in clinical features of type 1 and type 2 diabetes diagnosed before the age of 30 years. Type 2 diabetes had a male dominancy, while there has been a female dominancy in patients with type 1 diabetes as in previous reports of Japanese childhood-onset type 1 diabetes. Such dominances had been continued over the last 40 years. The number of patients with type 2 diabetes and with a past history of obesity increased with time. The age at which type 2 diabetes was diagnosed was suggested to have been getting lower with time, whereas that of type 1 diabetes has been higher with time. There was no marked difference in family history of diabetes in the first-degree relatives of patients with type 2 diabetes, regardless of the presence or absence of a past history of obesity. More female patients with type 2 diabetes diagnosed before the age of 15 years had mothers with type 2 diabetes compared to corresponding male patients.

authors

Uchigata Y,Otani T,Takaike H,Miura J,Osawa M,Tukahara S,Kasahara T,Iwamoto Y

doi

10.1016/j.diabres.2008.06.021

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

80-6

issue

1

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(08)00286-6

journal_volume

82

pub_type

杂志文章
  • Achievement of metabolic control goals set by the American Diabetes Association and the International Society for Pediatric and Adolescent Diabetes in pediatric patients with type 1 diabetes from Spain.

    abstract:AIM:The "T1D Exchange Clinic Registry" of 13.316 pediatric patients with type 1 diabetes (T1D) in U.S. recently revealed that most children have HbA1c values above target levels established by the American Diabetes Association (ADA) and the International Society for Pediatric and Adolescent Diabetes (ISPAD). The aim of...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2014.08.033

    authors: Enes P,Martín-Frías M,Álvarez MÁ,Yelmo R,Alonso M,Barrio R

    更新日期:2015-02-01 00:00:00

  • Auditory function in young patients with type 1 diabetes mellitus.

    abstract::Comprehension of the effect of diabetes mellitus on auditory function has been hindered by the fact that previous studies have evaluated hearing function in heterogeneous groups of patients with diabetes mellitus, thus giving conflicting results. We have performed audiometric studies in 46 consecutive patients. 13 wit...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/0168-8227(91)90136-2

    authors: Ferrer JP,Biurrun O,Lorente J,Conget JI,de España R,Esmatjes E,Gomis R

    更新日期:1991-01-01 00:00:00

  • A polymorphism (D20S32e) close to the human melanocortin receptor 3 is associated with insulin resistance but not the metabolic syndrome.

    abstract::Insulin resistance (IR) is postulated to underlie diabetes, the metabolic syndrome (MS) and cardiovascular disease (CVD). The D20S32e marker close to the melanocortin receptor-3 (hMC3-R) has been shown to be associated with IR in a large New Zealand Māori kindred, a population at high risk for MS and CVD. Here we exam...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2007.11.002

    authors: Wong J,Nock NL,Xu Z,Kyle C,Daniels A,White M,Yue DK,Elston RC,Mountjoy KG

    更新日期:2008-05-01 00:00:00

  • Novel mutations in ATPase 8, ND1 and ND5 genes associated with peripheral neuropathy of diabetes.

    abstract::Type 2 diabetes (T2D), being a complex, multi factorial metabolic disorder, its chronic complications development remains puzzled. In this case report, we describe four novel mutations in Cyt b, ATPase 8, ND1 and ND5 genes' synergistic activity as plausible factors for the secondary complications of a patient with chr...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2013.12.015

    authors: Elango S,Venugopal S,Thangaraj K,Viswanadha VP

    更新日期:2014-03-01 00:00:00

  • Country of birth modifies the association of fatty liver index with insulin action in Middle Eastern immigrants to Sweden.

    abstract:AIMS:Non-alcohol fatty liver disease (NAFLD) is a strong risk factor for insulin resistance and type 2 diabetes. The prevalence of NAFLD varies across populations of different ethnic backgrounds but the prevalence in Middle Eastern populations, which are at high risk of type 2 diabetes, is largely unknown. Using fatty ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2015.07.011

    authors: Bennet L,Groop L,Franks PW

    更新日期:2015-10-01 00:00:00

  • Prevalence of chronic complications in Japanese diabetic patients.

    abstract::In November 1990, we carried out a survey of chronic complications of diabetes in more than 2000 diabetic patients who were seen on one day in 35 medical institutions including university hospitals, other hospitals and small clinics. More than 60% were aged 55-74 years. About 7% of patients had IDDM. Hypertension was ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/0168-8227(94)90244-5

    authors: Kuzuya T,Akanuma Y,Akazawa Y,Uehata T

    更新日期:1994-10-01 00:00:00

  • Summer camp.

    abstract::The first summer camp in Japan was held at a site near Tokyo in 1963. The guide book was edited by Japan Diabetes Society in 1984. In 1992, 1012 children with diabetes participated at 36 sites all across Japan. The programme is characterized by the smooth combination between education for the children and their experi...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/0168-8227(94)90263-1

    authors: Mimura G

    更新日期:1994-10-01 00:00:00

  • An examination of the covariability of subclinical albuminuria in insulin-dependent diabetes mellitus: implications for monitoring microalbuminuria.

    abstract::We examined the covariability of subclinical albuminuria in a cohort of 160 insulin-dependent diabetics who underwent simultaneous measurements of overnight urinary albumin excretion rate (UAV) and several clinical variables on 7 occasions over a period of 18 months. After allowing for within-patient correlation betwe...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/0168-8227(93)90067-f

    authors: Watts GF,Taub NA,Mazurkiewicz J,Shaw KM

    更新日期:1993-08-01 00:00:00

  • Association of serum apolipoprotein C III levels and apolipoprotein C III gene Sst I polymorphism with carotid intima-media thickness in Chinese type 2 diabetic patients.

    abstract::Apolipoprotein C III (apo C III) plays a central role in regulating plasma metabolism of triglyceride-rich lipoprotein (TRL). The G3238C allele (Sst I) in the 3'-untranslated region has been found to be associated with raised apo C III levels and hypertriglyceridemia (HTG). Some studies suggest that apo C III and the ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2004.02.020

    authors: Chen X,Tian H,Liu R

    更新日期:2004-10-01 00:00:00

  • ICA and organ-specific autoantibodies among Japanese patients with early-onset insulin-dependent diabetes mellitus--the JDS study.

    abstract::The Japan Diabetes Society (JDS) conducted a multicenter study on the immunogenetics of insulin-dependent diabetes mellitus (IDDM) among Japanese. The previous report of the JDS study described HLA types and other immunogenetic markers in Japanese patients with IDDM. In the present report, the autoimmunity of Japanese...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/0168-8227(94)90104-x

    authors: Kida K,Mimura G,Kobayashi T,Matsuura N,Toyota T,Kitagawa T,Hibi I,Ikeda Y,Tuchida I,Kuzuya H

    更新日期:1994-04-01 00:00:00

  • Different impacts of acylated and non-acylated long-acting insulin analogs on neural functions in vitro and in vivo.

    abstract:AIMS:Centrally administered insulin improves cognitive functions in patients with Alzheimer's disease; however, it remains unknown whether long-acting insulin analogs exert more pronounced effects than insulin. In the present study, we directly compared the effects of insulin and its analogs on neural functions in vitr...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2017.03.032

    authors: Tsuneki H,Yoshida H,Endo K,Mori N,Hosoh S,Tsuda M,Wada T,Sasaoka T

    更新日期:2017-07-01 00:00:00

  • Increased serum pigment epithelium-derived factor levels in type 1 diabetic patients with diabetic retinopathy.

    abstract::Serum pigment epithelium-derived factor (PEDF) levels were significantly higher in type 1 diabetic patients with retinopathy (n=20, 10.38+/-3.87 microg/ml) compared to the patients without it (n=57, 7.68+/-2.80 microg/ml) (p=0.0013). Elevated PEDF levels may be related to the progression of diabetic retinopathy. ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2008.03.009

    authors: Katakami N,Kaneto H,Yamasaki Y,Matsuhisa M

    更新日期:2008-07-01 00:00:00

  • Altered circulating mitochondrial DNA and increased inflammation in patients with diabetic retinopathy.

    abstract:AIMS:We previously showed that circulating mitochondrial DNA (MtDNA) levels are altered in diabetic nephropathy. The aim of the current study was to determine if circulating MtDNA levels are altered in patients with diabetic retinopathy. METHODS:Patients with diabetes (n=220) were studied in a clinical setting using a...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2015.10.006

    authors: Malik AN,Parsade CK,Ajaz S,Crosby-Nwaobi R,Gnudi L,Czajka A,Sivaprasad S

    更新日期:2015-12-01 00:00:00

  • Elevated liver enzymes in women with a family history of diabetes.

    abstract::Both elevated liver enzymes and a family history of diabetes mellitus (FHDM) are independent risk factors for type 2 diabetes. This study evaluates the epidemiological association between elevated liver enzymes and FHDM. Subjects included 3512 women workers without diabetes, hepatitis, a smoking habit, or a history of...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2007.10.032

    authors: Inoue K,Matsumoto M,Miyoshi Y,Kobayashi Y

    更新日期:2008-03-01 00:00:00

  • Altered immune profile from pre-diabetes to manifestation of type 1 diabetes.

    abstract:BACKGROUND:While the mechanisms leading to β-cell destruction and clinical onset of T1D are still unclear, the composition of the immune profile is probably important for the outcome of immune activity. The aim of this study was to investigate the composition and possible changes of the immunological profile, spontaneo...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2013.01.014

    authors: Rydén A,Faresjö M

    更新日期:2013-04-01 00:00:00

  • Trends in deliveries in women with gestational diabetes in Spain, 2001-2008.

    abstract::We examined trends and characteristics of deliveries in women with gestational diabetes in Spain from 2001 to 2008. There were 101,643 deliveries with gestational diabetes among 2,782,369 delivery discharges (3.6%) with no increase over time. Rate of caesarean section increased (19-24.2%) and length of stay decreased....

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2010.10.005

    authors: Lopez-de-Andres A,Carrasco-Garrido P,Gil-de-Miguel A,Hernandez-Barrera V,Jiménez-García R

    更新日期:2011-02-01 00:00:00

  • Urinary excretion of type IV collagen and laminin in the evaluation of nephropathy in NIDDM: comparison with urinary albumin and markers of tubular dysfunction and/or damage.

    abstract::To clarify the diagnostic relevance of urinary type IV collagen (IV-C) and laminin in diabetic nephropathy, the excretion of these basement membrane proteins were determined by enzyme immunoassay in 172 non-insulin-dependent diabetic patients with different grades of nephropathy and 64 non-diabetic control subjects, a...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/0168-8227(95)01119-x

    authors: Banu N,Hara H,Okamura M,Egusa G,Yamakido M

    更新日期:1995-07-01 00:00:00

  • Non-insulin-dependent diabetes in Kuwait: prevalence rates and associated risk factors.

    abstract::Non-insulin-dependent diabetes mellitus (NIDDM) is a major clinical and public health problem in Kuwait. The objective of the study was to determine prevalence rates of NIDDM among a representative sample of the Kuwaiti adult population aged 20 and older in two out of five governorates and identify the associated risk...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/s0168-8227(98)00104-1

    authors: Abdella N,Al Arouj M,Al Nakhi A,Al Assoussi A,Moussa M

    更新日期:1998-12-01 00:00:00

  • A case of fulminant type 1 diabetes mellitus with exocrine pancreatic insufficiency and enhanced glucagon response to meal ingestion.

    abstract::Non-specific aggression to endocrine alpha and beta cells as well as exocrine pancreas has been suggested in fulminant type 1 diabetes (FT1DM), while its effect on glucagon secretion and exocrine function is unknown. Here, we report a FT1DM case with exocrine pancreatic insufficiency and enhanced glucagon response to ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2008.08.004

    authors: Yabe D,Kuroe A,Ohya M,Watanabe K,Kitatani N,Oku M,Kurose T,Seino Y

    更新日期:2008-11-01 00:00:00

  • Insulin resistance in Brazilian adolescent girls: association with overweight and metabolic disorders.

    abstract::We assessed the association between insulin resistance, overweight and metabolic disorders in a probabilistic sample of 388, 12-19-year-old girls from public schools in Niterói, Rio de Janeiro State, Brazil. Insulin resistance was determined using Homeostatic Model Assessment-Insulin Resistance (HOMA-IR). Overweight a...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2006.03.018

    authors: Alvarez MM,Vieira AC,Moura AS,da Veiga GV

    更新日期:2006-11-01 00:00:00

  • Saxagliptin is similar in glycaemic variability more effective in metabolic control than acarbose in aged type 2 diabetes inadequately controlled with metformin.

    abstract::This study compared the effects on glycaemic variability and glucose control between saxagliptin and acarbose as add-on therapies for aged T2DM inadequately controlled with metformin alone. The results showed that compared with acarbose-metformin, saxagliptin-metformin was more effective in glucose control with simila...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.diabres.2015.02.022

    authors: Wang MM,Lin S,Chen YM,Shu J,Lu HY,Zhang YJ,Xie RY,Zeng LY,Mu PW

    更新日期:2015-06-01 00:00:00

  • Impact of gestational diabetes mellitus screening strategies on perinatal outcomes: a simulation study.

    abstract:AIMS:To evaluate the impact on perinatal outcomes of universal gestational diabetes (GDM) screening based on 1999 WHO and IADPSG diagnostic criteria; to assess the quality of the evidence (GRADE) to support GDM screening. METHODS:Simulation of a hypothetical cohort of community-based pregnant women with 10% GDM preval...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2012.12.009

    authors: Falavigna M,Prestes I,Schmidt MI,Duncan BB,Colagiuri S,Roglic G

    更新日期:2013-03-01 00:00:00

  • Diabetes among migrants in Denmark: Incidence, mortality, and prevalence based on a longitudinal register study of the entire Danish population.

    abstract:OBJECTIVE:Studies of diabetes in migrant populations have shown a higher prevalence compared to their respective countries of origin and to people natively born in the host country, but there is little population-based data on diabetes incidence and mortality in migrant populations. The aim of the current study was (1)...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2016.09.020

    authors: Andersen GS,Kamper-Jørgensen Z,Carstensen B,Norredam M,Bygbjerg IC,Jørgensen ME

    更新日期:2016-12-01 00:00:00

  • Excessive gestational weight gain and the risk of gestational diabetes: Comparison of Intergrowth-21st standards, IOM recommendations and a local reference.

    abstract:AIMS:To compare the abilities of Intergrowth-21st standards, Institute of Medicine (IOM) recommendations and a Chinese reference on gestational weight gain (GWG) to identify women at risk of gestational diabetes (GDM) and GDM-related adverse outcomes. METHODS:A retrospective cohort study was conducted on 13,366 women ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2019.107912

    authors: Jin C,Lin L,Han N,Zhao Z,Liu Z,Luo S,Xu X,Liu J,Wang H

    更新日期:2019-12-01 00:00:00

  • Evolution of OGTT in patients with beta-thalassaemia major in relation to chelation therapy.

    abstract::Glucose metabolism disturbances are frequently reported among patients with beta-thalassaemia major on conventional treatment consisted of regular blood transfusions and adequate chelation treatment. Aim of this study was to evaluate the evolution of oral glucose tolerance test (OGTT) in thalassaemic patients in relat...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2006.07.010

    authors: Christoforidis A,Perifanis V,Tsatra I,Vlachaki E,Athanassiou-Metaxa M

    更新日期:2007-04-01 00:00:00

  • Ethnic disparities in the association of impaired fasting glucose with the 10-year cumulative incidence of type 2 diabetes.

    abstract:AIMS:Evidence of ethnic disparities in the conversion of prediabetes to type 2 diabetes is scarce. We studied the association of impaired fasting glucose (IFG) and fasting plasma glucose (FPG) with the 10-year cumulative incidence of type 2 diabetes in three ethnic groups. METHODS:We analyzed data for 90 South-Asian S...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2013.10.014

    authors: Admiraal WM,Holleman F,Snijder MB,Peters RJ,Brewster LM,Hoekstra JB,Stronks K,van Valkengoed IG

    更新日期:2014-01-01 00:00:00

  • Importance of OGTT for diagnosing diabetes mellitus based on prevalence and incidence of retinopathy.

    abstract::Study was made on the necessity and importance of the oral glucose tolerance test (OGTT) for diagnosing diabetes mellitus based on prevalence and incidence of diabetic retinopathy. Subjects were 12208 persons undergoing OGTT between 1965 and 1997. The prevalence of retinopathy was significantly elevated with FPG>/=126...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/s0168-8227(00)00156-x

    authors: Ito C,Maeda R,Ishida S,Harada H,Inoue N,Sasaki H

    更新日期:2000-08-01 00:00:00

  • Serum high sensitivity C-reactive protein is associated with carotid intima-media thickness in type 2 diabetes.

    abstract:BACKGROUND:High sensitivity C-reactive protein (hsCRP) is more sensitive than standard C-reactive protein (CRP) assay in evaluating the risk of coronary heart disease and other atherosclerotic events. By this time, there are several reports that type 2 diabetic subjects have higher serum levels of hsCRP than those of n...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2004.05.009

    authors: Kang ES,Kim HJ,Kim YM,Lee S,Cha BS,Lim SK,Kim HJ,Lee HC

    更新日期:2004-12-01 00:00:00

  • Elevated erythrocyte sodium-lithium counter-transport in hypertensive patients with non-insulin-dependent diabetes mellitus.

    abstract::Increased erythrocyte (RBC) sodium-lithium (Na-Li) counter transport (CT) has been reported to be a genetic marker for essential hypertension (EHT). In addition, increased RBC Na-Li CT has been demonstrated in insulin-dependent diabetic (IDDM) patients with nephropathy, indicating that a predisposition to hypertension...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/0168-8227(96)01206-5

    authors: Senda T,Serizawa N,Negishi K,Katayama S

    更新日期:1996-03-01 00:00:00

  • Change in prevalence and 6-year incidence of diabetes and impaired fasting glucose in Korean subjects living in a rural area.

    abstract:AIMS:To determine the change in prevalence, incidence and risk factors associated with diabetes and impaired fasting glucose (IFG) in a rural Korean area. METHODS:Initially a total of 1119 subjects (424 men and 695 women) aged 31-99 years were recruited in 1997. Baseline clinical data and various laboratory values wer...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2007.04.011

    authors: Song KH,Nam-Goomg IS,Han SM,Kim MS,Lee EJ,Lee YS,Lee MS,Yoon S,Lee KU,Park JY

    更新日期:2007-12-01 00:00:00