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Microinflammation is a common risk factor for progression of nephropathy and atherosclerosis in Japanese patients with type 2 diabetes.

Abstract：

AIM:This study aimed to evaluate the change of serum levels of proinflammatory molecules in patients with type 2 diabetes and clarify the involvement of these molecules in diabetic nephropathy and atherosclerosis. METHODS:Sixty-six Japanese type 2 diabetic patients (T2DM) and 39 healthy control subjects were enrolled. We assessed clinical parameters, urinary albumin excretion rate (AER), brachial-ankle pulse wave velocity (baPWV), intima media thickness (IMT) and serum levels of proinflammatory molecules. RESULTS:Serum levels of IL-6, IP-10 and MCP-1 were significantly higher in T2DM than in control subjects. In T2DM, serum levels of high-sensitivity (hs) CRP, IP-10, hsTNF-alpha, VCAM-1 and E-selectin were positively correlated with AER. Serum levels of IP-10, hsTNF-alpha and VCAM-1 were positively correlated with baPWV. Serum levels of hsCRP, IL-6, IP-10 and hsTNF-alpha were positively correlated with IMT. Multiple linear regression analysis revealed that serum levels of hsTNF-alpha were independently associated with AER (beta=0.235, P=0.038) and serum levels of IP-10 were independently associated with baPWV (beta=0.209, P=0.047) and IMT (beta=0.303, P=0.032). CONCLUSION:Our results suggest that low-grade inflammation, microinflammation, may be a common risk factor for diabetic nephropathy and atherosclerosis in Japanese type 2 diabetic patients.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Kajitani N,Shikata K,Nakamura A,Nakatou T,Hiramatsu M,Makino H

doi

10.1016/j.diabres.2010.01.012

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

171-6

issue

2

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(10)00015-X

journal_volume

88

pub_type

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