Abstract：
AIMS:Studies have shown that diabetes mellitus disproportionately afflicts persons of low socioeconomic status and that the burden of disease is greatest among the disadvantaged. However, our understanding of educational differences in the control of diabetes and its impact on survival is limited. This study investigated the associations among education, hemoglobin A1c (HbA1c), and subsequent mortality in adults with diabetes. METHODS:Prospective cohort data from the 2006, 2008, and 2010 Health and Retirement Study were linked with biomarker data for U.S. older adults with diabetes (n=3312). Weighted distributions were estimated for all subjects at baseline and by the American Diabetes Association's general guidelines for HbA1c control (<7.0% [53 mmol/mol] vs. ≥7.0% [53 mmol/mol]). Proportional hazard models were used to estimate educational differences in all-cause mortality by HbA1c level with sequential adjustments for contributing risk factors. RESULTS:Mortality risks associated with HbA1c≥7.0% [53 mmol/mol] were significantly greater in lower-educated adults than higher-educated adults (P<0.001). We found that the hazard ratios (HR) associated with HbA1c ≥7.0% [53 mmol/mol] were highest among low-educated adults (HR=2.18, 95% CI: 1.62, 2.94) and that a combination of socioeconomic, psychosocial, and behavioral factors accounted for most, but not all, of the associations. CONCLUSIONS:Educational differences in HbA1c control have significant implications for mortality and efforts to reduce these disparities should involve more vigilant screening and monitoring of lower-educated adults with diabetes.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Dupre ME,Silberberg M,Willis JM,Feinglos MNdoi
10.1016/j.diabres.2014.12.013subject
Has Abstractpub_date
2015-03-01 00:00:00pages
392-9issue
3eissn
0168-8227issn
1872-8227pii
S0168-8227(15)00033-9journal_volume
107pub_type
杂志文章abstract：:We report a 19-year-old woman who had a history of type 1 diabetes with recurrent glycogen accumulation in the liver. During her infantile period she presented with no hepatomegaly nor growth retardation. On admission she was diagnosed with diabetic ketoacidosis (DKA). She also had hepatomegaly and elevated transamina...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2003.12.004
更新日期：2004-08-01 00:00:00
abstract：:We have recently reported increased cholesterol concentrations in high-density and very-low-density lipoproteins (HDL and VLDL) in sucrose-fed rats with exogenous hyperinsulinemia. In order to see if exogenous hyperinsulinemia has any effect on the alterations in plasma lipoproteins induced by cholesterol feeding, we ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(89)90032-6
更新日期：1989-04-01 00:00:00
abstract：OBJECTIVE:Several genome-wide association studies and replication analyses have identified common variation at the insulin-like binding protein 2 (IGF2BP2) gene to be associated with type 2 diabetes (T2DM). The aim of this study was to replicate in a Lebanese Arab population identified associations of IGF2BP2 variants ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2011.12.026
更新日期：2012-05-01 00:00:00
abstract：:Experimental data support a role for insulin and insulin-like growth factor-I (IGF-I) in the pathophysiology of vascular complications in diabetes. Clinical data for both hormones are less convincing, mainly because the various studies vary in methodologies, sample sizes, and populations. So far, by epidemiological me...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/s0168-8227(96)80045-3
更新日期：1996-02-01 00:00:00
abstract：BACKGROUND:Previous reports have suggested an association between elevated fibrinogen and CAD. Few studies have so far investigated the impact of diabetes on fibrinogen levels and its association with coronary artery disease (CAD) and platelet reactivity in diabetic patients that are therefore the aims of the current s...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2015.05.038
更新日期：2015-09-01 00:00:00
abstract：:A new insulin sensitivity index was devised on the basis of an autoregressive model and its validity was investigated. Using data from the 75-g oral glucose tolerance test (OGTT), 115 subjects were divided into 3 groups: 40 with normal glucose tolerance, 34 with impaired glucose tolerance, and 41 with type 2 diabetes ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2007.05.005
更新日期：2008-01-01 00:00:00
abstract：:In the present study, we recruited 124 patients with type 2 diabetes, among which 22 had a history of cardiovascular disease (CVD). The study demonstrated that compared with type 2 diabetes without CVD, those with CVD had remarkably higher levels of angiopoietin-like protein 8 (ANGPTL8). Moreover, the close relationsh...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2016.08.017
更新日期：2016-10-01 00:00:00
abstract：:We investigated the incidence of the slowly progressive form of type 1 diabetes (SPT1D) detected by the urine glucose-screening tests at schools in the Tokyo Metropolitan Area from 1974 to 2004. During this study period, a total of 9,242,259 school students underwent the screening program. Of them, 54 children, 19 mal...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1016/j.diabres.2008.01.029
更新日期：2008-06-01 00:00:00
abstract：:Possible factors that might influence the outcome of continuous subcutaneous insulin infusion (CSII) treatment were investigated in forty-nine, type 1, diabetic patients with median treatment of 3.25 years in routine diabetes care. In nine patients pump treatment was discontinued largely within the first 6 months. Pat...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(93)90145-u
更新日期：1993-01-01 00:00:00
abstract：:The limitations of current basal insulin preparations include concerns related to their pharmacokinetic and pharmacodynamic properties, hypoglycaemia, weight gain, and perception of management complexity, including rigid dosing schedules. Insulin degludec (IDeg) is a novel basal insulin with improved pharmacokinetic a...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/j.diabres.2015.04.002
更新日期：2015-07-01 00:00:00
abstract：:Hyperleptinemia, hypoadiponectinemia, and hyperresistinemia were found to be significantly higher with odds ratios (CI 95%) of 2.15, 2.05 and 3.05, respectively, among cigarette smokers with type 2 diabetes in Saudi Arabian population. Smoking cessation restored the adiponectin and leptin levels while having a modest ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2008.11.013
更新日期：2009-02-01 00:00:00
abstract：:The present study was undertaken to compare the changes in islet cell antibodies (ICA), islet cell surface antibodies using rat insulinoma cells (RINr-ICSA), and anti-bovine serum albumin antibodies (BSA-Ab) in the clinical course of type 1 (insulin-dependent) diabetes. Sera were obtained from 57 patients with type 1 ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(90)90047-w
更新日期：1990-07-01 00:00:00
abstract：BACKGROUND:The relation between diabetes mellitus (DM) and mortality among patients with acute myocardial infarction is still controversial. We evaluated the influence of DM on the in-hospital mortality of acute myocardial infarction (AMI) patients using data from the Tokai Acute Myocardial Infarction Study-II, a multi...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1016/j.diabres.2006.04.011
更新日期：2007-01-01 00:00:00
abstract：AIM:This study aimed to systematically review the prevalence of diagnosed sleep disorders in people with diabetes and to determine the association between sleep disorders and blood glucose levels and diabetes outcomes. METHODS:We conducted a literature search in the following databases: MEDLINE (Pubmed), EMBASE, CINAH...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108035
更新日期：2020-03-01 00:00:00
abstract：:The understanding that statins reduce but not eliminate the cardiovascular risk associated with disturbed lipid metabolism and the existence of forms of dyslipidemia that are unresponsive or only partially responsive to statins have led to the development of many novel lipid-lowering drugs. Accumulating evidence sugge...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/j.diabres.2017.12.012
更新日期：2018-03-01 00:00:00
abstract：:A low-carbohydrate/high-fat evening meal impaired the glucose tolerance of healthy subjects to almost the same extent as the impairment caused by overnight fasting. This suggests that the decreased component (carbohydrate) is more relevant than the increased component (fat) to the impairment of glucose tolerance by a ...
journal_title：Diabetes research and clinical practice
pub_type： 信件
doi：10.1016/s0168-8227(01)00291-1
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Type 1 diabetes (T1D) is one of the most common chronic health conditions in adolescents in the United States. Adherence to the recommended treatment regimen has been reported as a source of stress for adolescents. AIM:The purpose of this study was to examine the associations among general and diabetes-spec...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2017.05.003
更新日期：2017-08-01 00:00:00
abstract：:The present study aims at identifying main barriers faced by people living with diabetes in Brazil during the COVID-19 pandemic. METHODS:In a convenience sampling study, data were collected from 1701 individuals, aged 18 or above; 75.54% female participants; 60.73% T1D and 30.75% T2D, between April 22nd and May 4th, ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108304
更新日期：2020-08-01 00:00:00
abstract：:The aim of this study was to investigate the effect of resveratrol on beta cells in male C57BL/6J mice fed a high-fat diet and the possible mechanisms. Male C57BL/6J mice were randomly divided into three groups: normal control (NC) group, high-fat diet (HF) group and high-fat diet and resveratrol treatment (HFR) group...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2012.02.029
更新日期：2012-09-01 00:00:00
abstract：AIMS:Central obesity, a prominent feature of metabolic syndrome (MetS), is commonly assessed by gender- and ethnicity-specific waist circumference (WC) cut-off values. Since 2006, the recommended WC cut-offs by the International Diabetes Federation (IDF) for Europeans are used in Iran because of limited data availabili...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2008.07.009
更新日期：2008-10-01 00:00:00
abstract：:The aim of this study was to investigate the relationships between daily stress and glycaemic control in 54 people with Type 1 diabetes over 21 days. Measures included daily reports of stress (hassles), four-times-daily blood glucose measurements, and HbA1c levels. Time-series analyses revealed considerable variation ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2004.04.001
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:We examined the accuracy of random capillary glucose (RCG) and two noninvasive screening methods, the ADA diabetes risk test (DRT) and skin fluorescence spectroscopy (SFS) as measured by Scout DS for detecting HbA1c-defined dysglycemia or type 2 diabetes in an at-risk cohort. METHODS:Subjects were recruited...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1016/j.diabres.2013.01.002
更新日期：2013-04-01 00:00:00
abstract：AIM:To assess the level of awareness and provision of screening and treatment for Diabetic Eye Disease (DED) comprising Diabetic Retinopathy (DR) and Diabetic Macular Edema (DME) among health care professionals. METHODS:The study was conducted in two phases. The first phase consisted of a qualitative study, based on s...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1016/j.diabres.2018.07.004
更新日期：2018-09-01 00:00:00
abstract：:To investigate the involvement of islet amyloid polypeptide (IAPP) and amyloid deposits in the pathophysiology of this disease, we studied the relationship between IAPP-derived amyloid deposition and the clinical features in type 2 diabetes mellitus. We examined pancreata obtained from 37 type 2 diabetic subjects and ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(92)90062-v
更新日期：1992-01-01 00:00:00
abstract：AIMS:To determine the prevalence of inadequate glycemic control and its correlates in a large multicenter survey of Venezuelan patients with diabetes. METHODS:A cross-sectional study in a sample of adult patients with diabetes, attending health centers in Venezuela. Information about diabetes, current medications, com...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1016/j.diabres.2009.12.014
更新日期：2010-03-01 00:00:00
abstract：:Four patients who exhibited the greatest decline in the estimated glomerular filtration rate [12.3-23.5 ml/min/1.73 m(2)/year] among 320 patients with type 2 diabetes and were followed for a median of 6.8 years had several clinical features in common, including marked albuminuria, microhematuria, retinopathy and poor ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2013.01.031
更新日期：2013-05-01 00:00:00
abstract：:This study investigated the long-term efficacy and safety of empagliflozin as add-on to metformin plus sulphonylurea in patients with type 2 diabetes mellitus (T2DM). Of 666 patients treated with empagliflozin 10 mg, empagliflozin 25 mg or placebo once daily for 24 weeks, 472 patients (70.9%) were treated in a double-...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabres.2015.05.044
更新日期：2015-10-01 00:00:00
abstract：:Administration of insulin with premeal boluses of short-acting insulin using a new injection device (Novopen) was compared with a conventional three times daily injection regimen regarding aspects of quality of life and metabolic control in insulin-dependent diabetes mellitus (IDDM). Eighteen C-peptide-negative patien...
journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0168-8227(89)90055-7
更新日期：1989-01-03 00:00:00
abstract：:The prevalence of obesity observed in this study seems higher than that reported in the previous study. This is probably due to the characteristics of the subjects studied, since they were subjects admitted for health examinations with possible selection. However, the observation in this study clearly indicated that o...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(90)90153-k
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was to examine the impact of insulin sensitivity and muscle fibre composition to exercise capacity in individuals with type 2 diabetes (T2D), impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). METHODS:Thirty-nine male patients with T2D, 44 male subjects with IGT and 5...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2011.05.022
更新日期：2011-10-01 00:00:00
