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Islet amyloid polypeptide-derived amyloid deposition increases along with the duration of type 2 diabetes mellitus.

Abstract：

:To investigate the involvement of islet amyloid polypeptide (IAPP) and amyloid deposits in the pathophysiology of this disease, we studied the relationship between IAPP-derived amyloid deposition and the clinical features in type 2 diabetes mellitus. We examined pancreata obtained from 37 type 2 diabetic subjects and 12 non-diabetic ones by immunohistochemical techniques using two specific antibodies to IAPP. IAPP-derived deposits occurred in 1 of the 12 (8.3%) non-diabetic subjects and 28 of the 37 (75.7%) diabetics. When diabetic patients were divided into categories according to the presence of the deposits, the duration of the disease was significantly longer in patients with amyloid than that in the patients without it. The odds ratio of type 2 diabetes mellitus of at least 14-years-duration to the deposition was significantly high, and a body weight of at least 120% maximal ideal body weight was relatively high. In conclusion, IAPP-derived amyloid deposition increases along with the duration of type 2 diabetes mellitus and obesity may further enhance these deposits, hence hypersecretion of IAPP may be involved in the progression of this disease.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Ohsawa H,Kanatsuka A,Mizuno Y,Tokuyama Y,Takada K,Mikata A,Makino H,Yoshida S

doi

10.1016/0168-8227(92)90062-v

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

17-21

issue

1

eissn

0168-8227

issn

1872-8227

pii

0168-8227(92)90062-V

journal_volume

15

pub_type

杂志文章

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