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The effect of an aldose reductase inhibitor on cardiovascular performance in patients with diabetes mellitus.

Abstract：

:Because some aldose reductase inhibitor studies have demonstrated clinical improvement in scored neurological signs and symptoms of diabetic neuropathy, a prospective study of the effect on cardiovascular performance of sorbinil 250 mg/day for 12 months was conducted on patients with diabetic autonomic neuropathy who were free of atherosclerotic coronary artery disease and/or cardiomyopathy. After 1 year of treatment, the study group (n = 14) demonstrated significant improvement in both the resting cardiac output (P = 0.02), and the maximal cardiac output (P = 0.03). This observation suggests that the use of an aldose reductase inhibitor may be useful in treating suboptimal cardiovascular performance in patients with diabetic cardiac autonomic neuropathy.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Roy TM,Broadstone VL,Peterson HR,Snider HL,Cyrus J,Fell R,Rothchild AH,Samols E,Pfeifer MA

doi

10.1016/0168-8227(90)90086-9

subject

Has Abstract

pub_date

1990-08-01 00:00:00

pages

91-7

issue

1

eissn

0168-8227

issn

1872-8227

pii

0168-8227(90)90086-9

journal_volume

10

pub_type

杂志文章

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