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Estimation of influence of gastric emptying on shape of glucose concentration-time profile measured in oral glucose tolerance test.

Abstract：

AIMS:To develop a model for simulations of processes in the oral glucose tolerance test (OGTT), using tools of the theory of dynamic systems. METHODS:Frequent sampling OGTT was performed in 13 healthy subjects (6 males and 7 females). Subsequently, employing glucose and insulin concentration-time profiles of the subjects, the model was developed. RESULTS:In all subjects the model was able to simulate influences of the insulin plasma concentration and gastric emptying rate on glucose concentration and to determine time profiles of glucose fractions retained in stomach. CONCLUSIONS:The approach presented represents an opportunity for building models for data analyses in OGTT.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Dedík L,Durisová M,Penesová A,Miklovicová D,Tvrdonová M

doi

10.1016/j.diabres.2006.12.017

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

377-84

issue

3

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(07)00004-6

journal_volume

77

pub_type

杂志文章

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