Abstract:
:We analysed blood insulin and glucose concentrations before and during frequently sampled intravenous glucose tolerance tests (FSIGT) in 2 groups of Nigerian subjects: (A) Control group (n = 18), without a positive family history of diabetes mellitus, and (B) Experimental group (n = 16), comprising age-, sex- and body mass-matched first-degree relatives of patients with non-insulin-dependent diabetes mellitus (NIDDM). In comparison with Group A subjects, those in Group B had: (i) higher fasting plasma glucose level (mean +/- S.E.M. 4.1 +/- 0.1 vs. 3.8 +/- 0.11 mmol/l, P < 0.05); (ii) similar fasting serum insulin levels (6.7 +/- 5.0 vs. 5.8 +/- 5.6 mU/l, P = NS); (iii) lower mean incremental area under the first-phase (t = 0-10 min) post-glucose challenge insulin curve (376.9 +/- 8.8 vs. 435.6 +/- 5.6 mU/min l-1, P < 0.05); (iv) increased incremental area under the second-phase (t = 10-182 min) post-glucose challenge insulin curve (432.9 +/- 11.5 vs. 161.3 +/- 8.7 mU/min l-1, P < 0.05); (v) reduced KG rate constant of glucose elimination (0.97 +/- 0.12 vs. 1.41 +/- 0.12%/min, P < 0.05). These results suggest that the subjects with a positive family history of NIDDM have a reduced beta-cell insulin secretory reserve (from reduced first-phase insulin response), tendency to rebound hyperinsulinemia during the latter phase of the insulin secretory response, a degree of tissue insulin insensitivity (as evident from high fasting plasma glucose despite similar insulin levels) and a diminished glucose disposal rate, in comparison with subjects without a family history of NIDDM. These features predict subsequent development of diabetes and suggest that as in Caucasians, first-degree relatives of Nigerian patients with NIDDM are at greater risk for future development of the disease.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Ezenwaka CE,Akanji AO,Osei K,Adejuwon CA,O'Dorisio TM,Cottrell DA,Akinlade KSdoi
10.1016/0168-8227(93)90075-gsubject
Has Abstractpub_date
1993-06-01 00:00:00pages
175-81issue
3eissn
0168-8227issn
1872-8227pii
0168-8227(93)90075-Gjournal_volume
20pub_type
杂志文章abstract:AIMS:The epidemiology for diabetic retinopathy (DR) has been well described in the western population. Countries in Sub-Saharan Africa have attempted to identify the prevalence of diabetic eye disease, however, there still remains a degree of paucity across the continent due to inadequacy in health system organisations...
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
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abstract:OBJECTIVE:To determine if uncooked cornstarch, as part of the evening snack, can avert nocturnal hypoglycemia in type 1 diabetes. RESEARCH DESIGN AND METHODS:Fifty-one campers and counselors at the American Diabetes Association Camp in San Bernardino, CA were randomly assigned to receive 5 g of uncooked cornstarch as ...
journal_title:Diabetes research and clinical practice
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-12-01 00:00:00
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2003.08.007
更新日期:2004-03-01 00:00:00
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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journal_title:Diabetes research and clinical practice
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pub_type: 杂志文章,多中心研究
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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journal_title:Diabetes research and clinical practice
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更新日期:1991-02-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2018-01-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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更新日期:2010-10-01 00:00:00