Abstract：
AIMS:To understand the composition of the residual dysglycemia when HbA1c is between 6.5% (48mmol/mol) and 7% (53mmol/mol), representing the definition of diabetes and the recommended treatment goal, respectively. METHODS:One hundred persons with type 2 diabetes and a HbA1c<7% (53mmol/mol), treated with diet alone and/or oral hypoglycemic agents underwent continuous glucose monitoring (CGM) and were further divided into two subgroups 1 (n=50) and 2 (n=50) according to whether the HbA1c was <6.5% (48mmol/mol) or 6.5-6.9% (48-52mmol/mol), respectively. A similar analysis was performed in those on diet alone: subgroups A (n=34, HbA1c<6.5%, 48mmol/mol) and B (n=10, HbA1c 6.5-6.9%, 48-52mmol/mol). The residual dysglycemia determined from the CGM was assessed using glucose exposures defined as areas under curves (AUCs) and mean glucose values. RESULTS:Averaged 2-h postprandial glucose value (averaged PPG, mmol/L, mean±SD) and postprandial glucose exposure (AUCpp, mean±SD, mmol·L(-1)·h) were significantly higher in subgroup 2 (mean HbA1c=6.7%, 50mmol/mol) than in subgroup 1 (mean HbA1c=6.0%, 42mmol/mol): averaged PPG=8.1±1.3 versus 7.3±1.3mmol/L (p<0.002); AUCpp=23.5±8.6 versus 16.2±8.6 (p<0.0001). The percentages of persons with averaged PPG≥7.8mmol/L were 52% and 24% (p<0.01) in subgroups 2 and 1, respectively. Similar results were observed in those (subgroups A and B) who were on diet alone. CONCLUSIONS:The residual dysglycemia in type 2 diabetes with HbA1c between 6.5 and 6.9% (48-52mmol/mol) inclusive is mainly due to remnant abnormal postprandial glucose excursions. Consequently, HbA1c<6.5% (48mmol/mol) is an achievable goal with therapeutic measures aimed at reducing postmeal glucose when the HbA1c is at 7% (53mmol/mol).
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Monnier L,Colette C,Dejager S,Owens Ddoi
10.1016/j.diabres.2014.03.012subject
Has Abstractpub_date
2014-06-01 00:00:00pages
370-5issue
3eissn
0168-8227issn
1872-8227pii
S0168-8227(14)00168-5journal_volume
104pub_type
杂志文章abstract：AIMS:The aim of this study is to investigate the association between metformin usage and dementia in an elderly Korean population. METHODS:Participants were divided into five groups: metformin non-users with diabetes mellitus (DM), metformin users with DM (low-, mid-, and high-users), and non-diabetic Individuals. Dem...
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,随机对照试验
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更新日期：2013-02-01 00:00:00
abstract：:The influence of age on diabetic autonomic neuropathy was studied. In the present study autonomic neuropathy was assessed by cardiac beat-to-beat variation during deep breathing (BBV) and pupil area prior to photic stimulus (A1). In the studies on BBV a total of 440 subjects (11-82 years in age) were divided into thre...
journal_title：Diabetes research and clinical practice
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doi：10.1016/0168-8227(90)90008-h
更新日期：1990-04-01 00:00:00
abstract：:This prospective pilot study was undertaken to test the efficacy of oral methyl-prednisolone (MP) therapy at spontaneous remission phase of type 1 diabetes in intervening the course of the disease. Twenty-five type 1 diabetic patients who were classified as having a spontaneous remission (honeymoon) were divided into ...
journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章
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更新日期：1993-02-01 00:00:00
abstract：:To evaluate the effect of pioglitazone on insulin resistance in non-insulin-dependent diabetes mellitus (NIDDM) patients, a double-blind placebo-controlled trial was carried out with 30 NIDDM patients. Twenty-one subjects, three on diet alone and 18 on sulfonylurea (SU), orally received 30 mg pioglitazone once daily f...
journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：1998-07-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：2016-05-01 00:00:00
abstract：INTRODUCTION:Diabetes is a serious and increasing global health burden and estimates of prevalence are essential for appropriate allocation of resources and monitoring of trends. METHODS:We conducted a literature search of studies reporting the age-specific prevalence for diabetes and used the Analytic Hierarchy Proce...
journal_title：Diabetes research and clinical practice
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doi：10.1016/j.diabres.2013.11.002
更新日期：2014-02-01 00:00:00
abstract：AIM:To determine the possible factors predicting the insulin requirement in pregnancies complicated by gestational diabetes mellitus (GDM). METHOD:A total of 294 patients with GDM diagnosed by the 100-g/3-h oral glucose tolerance test (OGTT) were studied. The following factors were analyzed: maternal age, nulliparity,...
journal_title：Diabetes research and clinical practice
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更新日期：2010-04-01 00:00:00
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journal_title：Diabetes research and clinical practice
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更新日期：2008-09-01 00:00:00
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(90)90153-k
更新日期：1990-01-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
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更新日期：2015-04-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2013.06.005
更新日期：2013-09-01 00:00:00
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更新日期：2011-10-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2006-08-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
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pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2018-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1995-08-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2004.10.010
更新日期：2005-06-01 00:00:00
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更新日期：2013-04-01 00:00:00
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更新日期：1994-12-31 00:00:00
