Sphingosine-1-phosphate induced vasoconstriction is increased in the isolated perfused kidneys of diabetic rats.

Abstract:

:We observed that in isolated perfused rat kidneys, sphingosine-1-phosphate produces S1P(2) receptor-mediated vasoconstriction, and this response increased in kidneys of diabetic rats. These results suggest that the antagonists of S1P(2) receptor may have potential as drugs to control diabetes-induced vascular complications.

authors

Bautista-Pérez R,Arellano A,Franco M,Osorio H,Coronel I

doi

10.1016/j.diabres.2011.06.023

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

e8-11

issue

1

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(11)00345-7

journal_volume

94

pub_type

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