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C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance in patients with diabetes mellitus type 2.

Abstract：

BACKGROUND:The polymorphism 385 C/A of FAAH has been associated with overweight and obesity. The aim of our study was to investigate the relationship of polymorphism (cDNA 385 C-->A) of FAAH gene on obesity parameters in patients with diabetes mellitus type 2. DESIGN:A population of 70 patients with diabetes mellitus type 2 was analyzed. An anthropometric and biochemical nutritional assessment was performed. The statistical analysis was performed for the combined C358A and A358A as a group and wild type C358C as second group. RESULTS:Fifty-five patients (78.7%) had genotype C358C (wild type group) and 15 (21.3%) patients C358A (14 patients, 20.6%) or A358A (1 patient, 0.7%) (mutant group). BMI (38.9+/-6.4 vs. 39.2+/-5.7, p<0.05), weight (96.8+/-17.6kg vs. 102.5+/-16.8kg, p<0.05), fat mass (42.1+/-16.1kg. vs. 46.9+/-11.1kg, p<0.05), waist circumference (115.9+/-12.8cm vs. 121.3+/-12.8cm, p<0.05), insulin (22.5+/-18.8mUI/L vs. 33.9+/-17.1UI/L, p<0.05) and TNF-alpha (6.1+/-3.4pg/mL vs. 8.4+/-3.2pg/mL, p<0.05) were higher in mutant type group than wild type. Adiponectin levels (33.3+/-20.8ng/mL vs. 22.3+/-10.8ng/mL, p<0.05) were higher in wild type group than mutant type group. CONCLUSION:There is an association of the mutant type group A358C and A358A of FAAH with a worse cardiovascular profile (weight, body mass index, waist circumference, insulin,TNF-alpha and adiponectin levels) than wild type group.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

de Luis DA,Sagrado MG,Aller R,Izaola O,Conde R,Romero E

doi

10.1016/j.diabres.2009.12.019

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

76-80

issue

1

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(09)00544-0

journal_volume

88

pub_type

杂志文章

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