Abstract:
:The effect of short-term insulin treatment with a long-acting insulin preparation, Ultratard HM (U-HM) was investigated in eight non-insulin-dependent diabetes mellitus (NIDDM) patients whose previous glycemic control using diet was judged unsatisfactory. The treatment consisted of one daily pre-breakfast injection of U-HM (0.3 IU/kg) for 8 days. Glycemic control, assessed by mean plasma glucose (PG) daily profile and M-value, was improved significantly after U-HM treatment (mean PG and M-value, before: 223 +/- 19 mg/dl, 38.2; on the last day of U-HM: 151 +/- 11 mg/dl, 16.3; P less than 0.001; P less than 0.05). Serum insulin (IRI) reached a peak at 14:30 h during U-HM treatment, and mean IRI level increased during U-HM treatment (before: 14.0 +/- 2.8; during U-HM: 19.9 +/- 2.7 microU/ml). The mean C-peptide (CP) level decreased during U-HM treatment. Daily urinary CP excretion also decreased during U-HM treatment (before: 52.7 +/- 4.2; during U-HM: 34.8 +/- 4.2 micrograms/24 h). The data indicated that a single daily injection of U-HM was effective to improve whole-day glycemic control in NIDDM patients.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Iwamoto Y,Matsuda A,Sakamoto Y,Kuzuya Tdoi
10.1016/s0168-8227(87)80058-xsubject
Has Abstractpub_date
1987-11-01 00:00:00pages
337-41issue
6eissn
0168-8227issn
1872-8227pii
S0168-8227(87)80058-Xjournal_volume
3pub_type
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journal_title:Diabetes research and clinical practice
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更新日期:2018-10-01 00:00:00
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journal_title:Diabetes research and clinical practice
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更新日期:2004-12-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/0168-8227(92)90015-j
更新日期:1992-02-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/s0168-8227(00)00134-0
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:Several genome-wide association studies and replication analyses have identified common variation at the insulin-like binding protein 2 (IGF2BP2) gene to be associated with type 2 diabetes (T2DM). The aim of this study was to replicate in a Lebanese Arab population identified associations of IGF2BP2 variants ...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2011.12.026
更新日期:2012-05-01 00:00:00
abstract::For an epidemiological study of childhood diabetes, application forms for medical benefits filed in Osaka Prefecture were collected and analyzed. A total of 465 patients with childhood diabetes under 18 yr of age were identified during the period between 1978 and 1988; 371 (175 boys and 196 girls) of them were classif...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/0168-8227(92)90145-h
更新日期:1992-12-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/0168-8227(95)01130-7
更新日期:1995-09-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2005.04.003
更新日期:2005-12-01 00:00:00
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journal_title:Diabetes research and clinical practice
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doi:10.1016/j.diabres.2018.01.038
更新日期:2018-04-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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更新日期:1997-03-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/s0168-8227(00)00211-4
更新日期:2001-02-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,多中心研究
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更新日期:2012-06-01 00:00:00
abstract:AIMS:We evaluated quality of diabetes care in low- and middle-income countries (LMIC) of Central and South America by documenting the ability to meet the guideline-recommended targets. We also identified barriers to achieving goals of treatment and characteristics of successful programs. METHODS:We searched the Nation...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2014.12.014
更新日期:2015-03-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2017.01.004
更新日期:2017-03-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2010.01.019
更新日期:2010-05-01 00:00:00
abstract::This retrospective study presents the mortality trends in diabetic patients in a developing region of the world. The data were collected by screening the hospital records of all diabetic patients who died over a period of a decade at Institute of Medical Sciences, a tertiary care medical centre in Kashmir Valley of In...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/s0168-8227(98)00112-0
更新日期:1999-01-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2011.03.031
更新日期:2011-07-01 00:00:00
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journal_title:Diabetes research and clinical practice
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doi:10.1016/j.diabres.2007.02.018
更新日期:2007-10-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2012.04.001
更新日期:2012-09-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2012.04.012
更新日期:2012-10-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/s0168-8227(01)00349-7
更新日期:2002-05-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2004.07.020
更新日期:2005-03-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2011.07.024
更新日期:2011-11-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/0168-8227(92)90152-h
更新日期:1992-08-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2009.07.001
更新日期:2009-09-01 00:00:00
abstract::This random multistage cross-sectional population survey was undertaken to determine the prevalence of diabetes mellitus (DM) and impaired glucose tolerance (IGT) in subjects aged 25 years and above in India. The study was carried out in 77 centers (40 urban and 37 rural). 18363 (9008 males and 9355 females) subjects ...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2004.04.008
更新日期:2004-12-01 00:00:00
abstract::Since Hirata et al. first reported a patient with insulin autoimmune syndrome in 1970, 197 cases have been reported in Japan as of December, 1992. The clinical profiles of these 197 cases were as follows; the peak age at onset was 60-69 years and peak duration of hypoglycemic attacks was more than 1 and less than 3 mo...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/0168-8227(94)90040-x
更新日期:1994-01-01 00:00:00
abstract::Apoptosis and its associated regulatory mechanisms are physiological events crucial to the maintenance of placental homeostasis; imbalance of these processes, however, such as occurs under various pathological conditions, may compromise placenta function and, consequently, pregnancy success. Increased apoptosis occurs...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2005.12.014
更新日期:2006-08-01 00:00:00