Abstract：
:We describe here four male patients with long-term and poorly controlled type 2 diabetes mellitus. They shared many common characteristic complications, such as severe autonomic neuropathy, proliferative retinopathy and normocytic normochromic anemia without progressive renal failure and macroangiopathy. They also showed normal levels of erythropoietin and reticulocyte, which was considered relatively low. The coefficient of variation of R-R, a useful method to estimate autonomic failure, showed markedly advanced autonomic neuropathy in all four patients. Coronary angiography did not reveal stenosis, anomaly or collateral vessels, but left ventriclography showed diffuse or partial hypokinesis. Massive proteinuria, high urinary levels of N-acetyl-beta-D-glucosamidase (NAG) and beta2-microglobulin (beta2M) were detected, though creatinine clearance (Ccr) was not so deteriorated. Treatment with recombinant erythropoietin increased their hemoglobin and hematocrit levels. These common points have a possibility to be brought about by tubulointerstitial damage and microangiopathy may be involved in it.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Saito T,Tojo K,Morimoto A,Tajima Ndoi
10.1016/j.diabres.2005.04.003subject
Has Abstractpub_date
2005-12-01 00:00:00pages
239-47issue
3eissn
0168-8227issn
1872-8227pii
S0168-8227(05)00142-7journal_volume
70pub_type
杂志文章abstract：AIMS:To determine the appropriate cutoff value of waist circumference associated with cardiometabolic risk factors in Koreans. METHODS:Clinical and laboratory data on 31,076 Korean adults (age 20-89 years, 40% women) were recorded at regular health check-ups. Receiver operating characteristic curves were used to deter...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2009.04.009
更新日期：2009-07-01 00:00:00
abstract：:We examined the preventive effect of Momordica charantia L. fruit (bitter melon) on hyperglycemia and insulin resistance in C57BL/6J mice fed with a high-fat (HF) diet. Firstly, mice were divided randomly into two groups: the control group was fed low-fat (LF) diet, whereas the experimental group was fed with a 45% HF...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2008.04.023
更新日期：2008-08-01 00:00:00
abstract：AIMS:Diabetes and its complications have a significant economic impact on individuals and their families, health systems and national economies. METHODS:The direct health expenditure of diabetes was calculated relying on the following inputs: diagnosed and undiagnosed diabetes prevalence estimates, United Nations popu...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108072
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVE:To explore the apoptotic role of amylin on human mesangial cell (MC). MATERIALS AND METHODS:Primarily cultured human MCs were applied and treated with fresh amylin preparation. Human MCs were identified by the morphology and immunofluorescence staining. The apoptotic cells were determined by ultrastructure c...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2007.02.018
更新日期：2007-10-01 00:00:00
abstract：AIMS:Metformin is the first-line treatment for most patients with type 2 diabetes but many patients need additional treatment with insulin secretagogues (IS) to achieve glycemic control. We aimed to compare mortality and cardiovascular risk among users of metformin in combination with pharmacologically different ISs. ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2014.09.047
更新日期：2015-01-01 00:00:00
abstract：AIMS:Several published diabetes prediction models include information about family history of diabetes. The aim of this study was to extend the previously developed German Diabetes Risk Score (GDRS) with family history of diabetes and to validate the updated GDRS in the Multinational MONItoring of trends and determinan...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2014.03.013
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:The aim of this study was to examine the impact of insulin sensitivity and muscle fibre composition to exercise capacity in individuals with type 2 diabetes (T2D), impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). METHODS:Thirty-nine male patients with T2D, 44 male subjects with IGT and 5...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2011.05.022
更新日期：2011-10-01 00:00:00
abstract：:The prevalence of diabetes mellitus (DM) and impaired glucose tolerance (IGT) and their relationship to age and obesity was estimated in a population-based survey in urban and rural areas in Baluchistan province, Pakistan. Cluster sampling of 834 adults (260 men, 574 women) in the urban and 570 adults (175 men, 395 wo...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(99)00017-0
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVE:The prevalence of treatment resistant hypertension (RH) depends on methods used for blood pressure (BP) measurements, goals of BP, and therapeutic efforts in terms of medication and adherence. We focused on diabetic subjects and explored the prevalence of RH in primary care practice. METHODS:In 1737 subjects...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2015.08.007
更新日期：2015-10-01 00:00:00
abstract：:We have investigated predictive value of HbA1c for hospital mortality and length of stay (LOS) in patients with type 2 diabetes admitted because of sepsis. A prospective observational study was implemented in a university hospital, 286 patients with type 2 diabetes admitted with sepsis were included. Leukocyte count, ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2006.10.017
更新日期：2007-07-01 00:00:00
abstract：AIMS:Vitamin K-dependent growth arrest-specific protein 6 (Gas6) and its receptors of the TAM (TYRO-3/Axl/Mer) family are ubiquitously expressed in immune, cardiovascular, and reproductive systems. They play pivotal roles of regulating tissue homeostasis via anti-inflammatory effects. Recent studies show that the Gas6/...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2013.12.057
更新日期：2014-02-01 00:00:00
abstract：:Our previous finding has shown that a suggestive linkage existed in D20S196 in diabetic families with lowered BMI in eastern Chinese population. The aim of this study is to investigate whether variants in PCK1 gene, located in this region, was associated with type 2 diabetes in eastern China. Eleven SNPs were identifi...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2008.10.011
更新日期：2009-02-01 00:00:00
abstract：:The effect of insulin on the serum levels of the amino-terminal propeptide of type III procollagen (PIIINP) was investigated in patients with non-insulin-dependent diabetes mellitus, whose disease was unsatisfactorily controlled by oral drugs. Before insulin therapy the PIIINP values of the patients (3.2 +/- 1.3 micro...
journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0168-8227(92)90096-a
更新日期：1992-09-01 00:00:00
abstract：AIMS:The current study sought to identify patient-level factors related to health care use among White and minority men and women with diabetes. METHODS:A sample of 447 of non-pregnant individuals with diabetes, ages 18-64, was drawn from the 2015-2016 National Health and Nutrition Examination Surveys dataset. Poisson...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2019.03.001
更新日期：2019-04-01 00:00:00
abstract：:The usefulness of nocturnal penile tumescence (NPT) monitoring with stamps was evaluated in diabetic males with impotence. The stamps, which were similar in paper and size to Japanese 10-yen postage stamps, were wrapped around the penis before sleep and the stamp ring was checked for breakage the next morning. Clinica...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(88)80018-4
更新日期：1988-02-19 00:00:00
abstract：OBJECTIVES:To compare cardiovascular risk factors and LDL particle size in well-controlled Type 2 diabetes mellitus and normal subjects. METHODS:Ninety-three Type 2 diabetic males and 186 age-matched, male controls were studied. Glycaemic control was stable for at least 3 months prior to recruitment. None were on insu...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(00)00211-4
更新日期：2001-02-01 00:00:00
abstract：AIMS:To determine if HLA-DP loci independently contribute to classic type 1 diabetes (T1D) of all ages, childhood-onset T1D and latent autoimmune diabetes in adults (LADA) among Chinese Han population. METHODS:A total of 518 patients with classic T1D (Among them 180 participants manifested T1D between 1-14 years), 519...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108582
更新日期：2020-12-08 00:00:00
abstract：OBJECTIVE:Studies of diabetes in migrant populations have shown a higher prevalence compared to their respective countries of origin and to people natively born in the host country, but there is little population-based data on diabetes incidence and mortality in migrant populations. The aim of the current study was (1)...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2016.09.020
更新日期：2016-12-01 00:00:00
abstract：:Insulin administration causes various types of immune response to insulin. However, there have been no reports that insulin administration triggers pancreatic beta-cell destruction in diabetic patients. We evaluated three patients who had suffered from type 2 diabetes or impaired glucose tolerance for 5-30 years. Afte...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2007.08.031
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:We examined the effect of a 14-month progressive resistance training (PRT) program on endothelial function in both a supervised training (Center) group and non-supervised training (Home) group of patients with type 2 diabetes. We studied 28 men and women with type 2 diabetes who participated in a 14-month PRT...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabres.2007.09.020
更新日期：2008-03-01 00:00:00
abstract：:Use of a real-time bedside glucose monitor was analyzed during the course of management of diabetic ketoacidosis (DKA) in children. Simultaneous determinations of blood glucose were obtained, using three methods: bedside glucose meter (One Touch II), laboratory glucose analyzer (YSI 2300 STAT), and a real-time bedside...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(99)00033-9
更新日期：1999-06-01 00:00:00
abstract：:Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in patients with diabetes. Oxidative stress has been postulated to be a major contributor to the pathogenesis of these events. There is considerable evidence that many biochemical pathways adversely affected by hyper...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/j.diabres.2007.01.036
更新日期：2007-09-01 00:00:00
abstract：:Self-monitoring of blood glucose (SMBG) in type 2 diabetic patients was compared across 14 countries. There was an unexpectedly high SMBG-use in non-insulin-treated patients. Reimbursement polices differed by country, region, insurance status, and patient income. More rigorous and systematic data collection is needed ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2008.08.021
更新日期：2008-12-01 00:00:00
abstract：AIMS:To determine whether intensive risk factor management reduced markers of inflammation in middle-aged and older people with type 2 diabetes who either had, or were at risk for cardiovascular disease (CVD), and whether these effects were mediated by adiposity. METHODS:The Action to Control Cardiovascular Risk in Di...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.diabres.2011.09.027
更新日期：2012-03-01 00:00:00
abstract：:Epidemiological risk factor patterns for diabetes mellitus determined by hemoglobin A1 and fasting blood glucose criteria were compared in the biethnic (Melanesian and Indian) nation of Fiji. The 2 diagnostic criteria elicited essentially similar risk factor patterns in Indians but ranking of predictors was altered in...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(87)80050-5
更新日期：1987-09-01 00:00:00
abstract：:The efficacy and safety of gliclazide (Diamicron) were studied in 29 NIDDM patients (19 men and 10 women aged 25-68 years) who failed to improve with diet or with diet plus a sulfonylurea. All patients were overweight and had fasting blood glucose levels consistently above 150 mg/dl (8.24 mmol/l). After withdrawal of ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(91)90012-3
更新日期：1991-01-01 00:00:00
abstract：:The study of diabetic neuropathy has been primarily in Europids, despite the high prevalence of diabetes in other populations. We set out to ascertain the prevalence of diabetic neuropathy and its risk factors in the island nation of Mauritius. Population surveys were carried out in 1987 and 1992 in Mauritius to estab...
journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0168-8227(98)00100-4
更新日期：1998-11-01 00:00:00
abstract：:Serum total sialic acid is a marker of the acute phase response. Elevated levels have also been associated with cardiovascular disease in the general Caucasian population and especially in Type 2 diabetic subjects. The purpose of this study was to estimate serum total sialic acid concentrations among Kuwaiti Type 2 di...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(00)00144-3
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:To investigate the association between C-reactive protein (CRP) and the risk of developing diabetes in Aboriginal Australians. RESEARCH DESIGN AND METHODS:High sensitivity CRP levels were measured in 620 Aboriginal participants aged 20-74 years free from diabetes at baseline in a remote community in the Nort...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2006.07.018
更新日期：2007-04-01 00:00:00
abstract：AIMS:Diabetes therapies that provide durable glycaemic control for people with type 2 diabetes mellitus (T2DM) are needed. We present efficacy results of albiglutide, a glucagon-like peptide-1 receptor agonist, in people with T2DM over a 3-year period. METHODS:Five of the 8 HARMONY phase 3 trials, comparing albiglutid...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.diabres.2017.06.013
更新日期：2017-09-01 00:00:00
