Abstract：
AIMS:Several published diabetes prediction models include information about family history of diabetes. The aim of this study was to extend the previously developed German Diabetes Risk Score (GDRS) with family history of diabetes and to validate the updated GDRS in the Multinational MONItoring of trends and determinants in CArdiovascular Diseases (MONICA)/German Cooperative Health Research in the Region of Augsburg (KORA) study. METHODS:We used data from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study for extending the GDRS, including 21,846 participants. Within 5 years of follow-up 492 participants developed diabetes. The definition of family history included information about the father, the mother and/or sibling/s. Model extension was evaluated by discrimination and reclassification. We updated the calculation of the score and absolute risks. External validation was performed in the MONICA/KORA study comprising 11,940 participants with 315 incident cases after 5 years of follow-up. RESULTS:The basic ROC-AUC of 0.856 (95%-CI: 0.842-0.870) was improved by 0.007 (0.003-0.011) when parent and sibling history was included in the GDRS. The net reclassification improvement was 0.110 (0.072-0.149), respectively. For the updated score we demonstrated good calibration across all tenths of risk. In MONICA/KORA, the ROC-AUC was 0.837 (0.819-0.855); regarding calibration we saw slight overestimation of absolute risks. CONCLUSIONS:Inclusion of the number of diabetes-affected parents and sibling history improved the prediction of type 2 diabetes. Therefore, we updated the GDRS algorithm accordingly. Validation in another German cohort study showed good discrimination and acceptable calibration for the vast majority of individuals.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Mühlenbruch K,Ludwig T,Jeppesen C,Joost HG,Rathmann W,Meisinger C,Peters A,Boeing H,Thorand B,Schulze MBdoi
10.1016/j.diabres.2014.03.013subject
Has Abstractpub_date
2014-06-01 00:00:00pages
459-66issue
3eissn
0168-8227issn
1872-8227pii
S0168-8227(14)00169-7journal_volume
104pub_type
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pub_type： 杂志文章,评审
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更新日期：2017-09-01 00:00:00
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journal_title：Diabetes research and clinical practice
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