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Acarbose in the treatment of elderly patients with type 2 diabetes.

Abstract：

AIMS:To study the effect of acarbose, an alpha-glucosidase inhibitor, on glycemic control in elderly patients with type 2 diabetes. METHODS:Elderly patients with type 2 diabetes treated with diet alone were randomly treated in a double-blind fashion with placebo (n=99) or acarbose (n=93) for 12 months. RESULTS:After 12 months of therapy, there was a statistically significant difference in the change in glycated haemoglobin (HbA(1c)) (-0.6%) in the acarbose group versus placebo, as well as in the incremental post-prandial glucose values (-2.1 mmol h/l) and mean fasting plasma glucose (-0.7 mmol/l). Although there was no effect of acarbose on insulin release, there was a clear effect of acarbose to decrease relative insulin resistance (-0.8) (HOMA method). In addition, acarbose was generally well tolerated and safe in the elderly; most discontinuations were due to gastrointestinal side effects such as flatulence and diarrhea. There were no cases of hypoglycemia reported, and no clinically relevant changes in laboratory abnormalities or vital signs during the study. CONCLUSIONS:Acarbose improves the glycemic profile and insulin sensitivity in elderly patients with type 2 diabetes who are inadequately controlled on diet alone.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Josse RG,Chiasson JL,Ryan EA,Lau DC,Ross SA,Yale JF,Leiter LA,Maheux P,Tessier D,Wolever TM,Gerstein H,Rodger NW,Dornan JM,Murphy LJ,Rabasa-Lhoret R,Meneilly GS

doi

10.1016/s0168-8227(02)00176-6

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

37-42

issue

1

eissn

0168-8227

issn

1872-8227

pii

S0168822702001766

journal_volume

59

pub_type

临床试验,杂志文章,随机对照试验

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