Abstract:
AIM:To assess changes in circulating incretin levels and body fat compositions with initial combination therapy with α-glucosidase inhibitor and dipeptidyl peptidase-4 inhibitor in patients with type 2 diabetes (T2D). METHODS:In this multicenter open-label 24-week trial, Japanese over-weight (BMI ≥ 25 kg/m(2)) patients with T2D not taking medication or taking metformin and/or sulfonylurea were randomly assigned to receive either 50mg of miglitol three times a day (M, n=14), 50mg of sitagliptin once a day (S, n=14), or a combination of both (M+S, n=13). Changes in plasma incretin levels during a meal tolerance test (MTT) and body fat composition with impedance method were evaluated. RESULTS:During MTT, postprandial plasma glucose levels decreased more after M+S than after M or S, and postprandial serum insulin levels decreased significantly after M and M+S whereas they increased after S. After M, active gastric inhibitory polypeptide (aGIP) decreased significantly at 30 min despite a significant increase at 120 min. After S, aGIP levels increased significantly throughout the MTT. After M+S, aGIP increased significantly at 0 and 120 min despite of significant decrease at 30 min. M+S further enhanced postprandial active glucagon-like peptide-1 levels during MTT than S did. Total body fat mass decreased significantly after M and M+S. Visceral fat mass decreased significantly only after M+S. Serum adiponectin increased significantly only after M+S. CONCLUSIONS:In over-weight patients with T2D, M+S may have a beneficial effect on adiposity with relation to these different effects on two incretins.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Mikada A,Narita T,Yokoyama H,Yamashita R,Horikawa Y,Tsukiyama K,Yamada Ydoi
10.1016/j.diabres.2014.09.040subject
Has Abstractpub_date
2014-12-01 00:00:00pages
538-47issue
3eissn
0168-8227issn
1872-8227pii
S0168-8227(14)00440-9journal_volume
106pub_type
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