Implication of a novel Gla-containing protein, Gas6 in the pathogenesis of insulin resistance, impaired glucose homeostasis, and inflammation: A review.

abstract：AIMS:To quantify the static and moving cutaneous sensibility threshold of diabetic patients using a neurosensory device for quantitative pressure detection. METHODS:Three hundred thirty-four (n = 334) patients with type 2 diabetes and no previous history of wounds on the feet were studied using the one- and two-point ...

journal_title：Diabetes research and clinical practice

authors： Carvalho VF,Ueda T,Paggiaro AO,Nascimento ARF,Ferreira MC,Gemperli R

更新日期：2019-11-01 00:00:00

abstract：AIMS:To investigate ethnic difference by focusing on fasting serum insulin (FSI) in inter-East Asian subjects with normal glucose tolerance (NGT) and impaired glucose regulation (IGR). METHODS:Data sources included MEDLINE and EMBASE between 2001 and 2007. We conducted a search for articles containing mean or geometri...

journal_title：Diabetes research and clinical practice

authors： Takeuchi M,Okamoto K,Takagi T,Ishii H

更新日期：2008-12-01 00:00:00

abstract：AIM:To describe coverage, cost and care of type 1 diabetes (T1D) in 2 regions of China--Beijing and Shantou--including: METHODS:This is a mixed-methods descriptive study with three arms--coverage, cost and care. It is taking place in 4 tertiary hospitals, 3 secondary hospitals and 4 primary health facilities in Beijin...

journal_title：Diabetes research and clinical practice

authors： McGuire H,Kissimova-Skarbek K,Whiting D,Ji L

更新日期：2011-11-01 00:00:00

abstract：:The effects of glucose (16.7 mM), potassium (50 mM), forskolin (20 microM), dibutyryl cyclic AMP (1 mM) and arachidonic acid (82 microM) upon insulin release and cytosolic free calcium concentrations ([Ca2+]i) were investigated in normal rat pancreatic islets. Potassium, forskolin and dibutyryl cyclic AMP significantl...

journal_title：Diabetes research and clinical practice

authors： Draznin B,Metz SA,Sussman KE,Leitner JW

更新日期：1987-09-01 00:00:00

abstract：:125I-Insulin binding to monocytes from 14 gestational diabetics was measured before and after 6 weeks of treatment with a 5500 kJ, low-fat, low-sucrose diet. After the hypoenergetic feeding of gestational diabetics, fasting plasma concentrations of glucose (P less than 0.01) and insulin (P less than 0.05) decreased si...

journal_title：Diabetes research and clinical practice

authors： Pedersen O,Beck-Nielsen H,Richelsen B,Bak J,Klebe J

更新日期：1985-01-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of both a single dose and daily oral administration for 15 days of the aqueous extract of the aerial part of Chamaemelum nobile (C. nobile) at a dose of 20mg/kg body weight on blood glucose concentrations and basal insulin levels in normal and streptozotocin-indu...

journal_title：Diabetes research and clinical practice

authors： Eddouks M,Lemhadri A,Zeggwagh NA,Michel JB

更新日期：2005-03-01 00:00:00

abstract：:We evaluated the effect of a diet rich in natural (NF) or extractive fibres (guar gum) on 12 male IDD (insulin-dependent diabetes) out-patients. The treatment lasted for 2 months. During the first month the patients were on an isocaloric diet containing 30 g of fibres and then they were randomly subdivided into two gr...

journal_title：Diabetes research and clinical practice

authors： Bruttomesso D,Briani G,Bilardo G,Vitale E,Lavagnini T,Marescotti C,Duner E,Giorato C,Tiengo A

更新日期：1989-02-15 00:00:00

abstract：:To clarify the histological changes of the cardiac autonomic nervous system in diabetes mellitus, ganglionic cells of the hearts of autopsy cases were examined light microscopically. In 7 severely diabetic patients, the ganglionic neurons showed cellular contraction, cytoplasmic condensation and poor staining of Nissl...

journal_title：Diabetes research and clinical practice

authors： Tsujimura T,Nunotani H,Fushimi H,Inoue T

更新日期：1986-06-01 00:00:00

abstract：:Inhibitors of dipeptidyl peptidase-IV (DPP-IV) are a novel class of anti-diabetes drugs; inhibiting the breakdown of incretins, they increase their biological availability and decrease thus blood glucose levels. However, in addition to regulating glucose homeostasis, DPP-IV has many diverse functions, such as modulati...

journal_title：Diabetes research and clinical practice

authors： Stulc T,Sedo A

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Previous reports have suggested an association between elevated fibrinogen and CAD. Few studies have so far investigated the impact of diabetes on fibrinogen levels and its association with coronary artery disease (CAD) and platelet reactivity in diabetic patients that are therefore the aims of the current s...

journal_title：Diabetes research and clinical practice

authors： Di Giovine G,Verdoia M,Barbieri L,Schaffer A,Aimaretti G,Bellomo G,Marino P,Suryapranata H,Sinigaglia F,De Luca G,Novara Atherosclerosis Study (NAS) group.

更新日期：2015-09-01 00:00:00

abstract：AIMS:Amounts of macrophages were infiltrated in glomeruli in diabetic nephropathy. Heparanase has been thought to be closely related to proteinuria. Our aims were to determine the effect of heparanase on the inflammation in AGEs-stimulated macrophages and its role on the functions of glomerular endothelial cells (GEnCs...

journal_title：Diabetes research and clinical practice

authors： Xu G,Qin Q,Yang M,Qiao Z,Gu Y,Niu J

更新日期：2017-02-01 00:00:00

abstract：AIMS:Deleterious effects of metabolic syndrome (MS) on bone are still controversial. In this study we evaluated the effects of a fructose-induced MS, and/or an oral treatment with metformin on the osteogenic potential of bone marrow mesenchymal stromal cells (MSC), as well as on bone formation and architecture. METHOD...

journal_title：Diabetes research and clinical practice

authors： Felice JI,Schurman L,McCarthy AD,Sedlinsky C,Aguirre JI,Cortizo AM

更新日期：2017-04-01 00:00:00

abstract：:Study was made on the necessity and importance of the oral glucose tolerance test (OGTT) for diagnosing diabetes mellitus based on prevalence and incidence of diabetic retinopathy. Subjects were 12208 persons undergoing OGTT between 1965 and 1997. The prevalence of retinopathy was significantly elevated with FPG>/=126...

journal_title：Diabetes research and clinical practice

authors： Ito C,Maeda R,Ishida S,Harada H,Inoue N,Sasaki H

更新日期：2000-08-01 00:00:00

abstract：:The effect of long-term (6 months) administration of voglibose in a dietary mixture (10 ppm) on intestinal disaccharidase activity was examined in non obese type 2 diabetes model Goto-Kakizaki (GK) rats. The postprandial blood glucose level in voglibose-treated GK rats was significantly lower than in untreated GK rats...

journal_title：Diabetes research and clinical practice

authors： Yasuda K,Shimowada K,Uno M,Odaka H,Adachi T,Shihara N,Suzuki N,Tamon A,Nagashima K,Hosokawa M,Tsuda K,Seino Y

更新日期：2003-02-01 00:00:00

abstract：AIM:To summarize the existing literature concerning the association between polypharmacy and adverse health consequences in elderly patients with type 2 diabetes mellitus. METHODS:We searched four literature databases (PubMed/Medline, ScienceDirect and Web of Science) through April 2019. We included all studies that a...

journal_title：Diabetes research and clinical practice

authors： Al-Musawe L,Martins AP,Raposo JF,Torre C

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To investigate association of psychosocial factors with anxiety and depressive symptoms in Chinese type 2 diabetes patients. METHODS:Three hundred and four type 2 diabetes patients were inquired with a structured questionnaire about socio-demographic characteristics, psychological stress, coping styles, soci...

journal_title：Diabetes research and clinical practice

authors： Zhang CX,Chen YM,Chen WQ

更新日期：2008-03-01 00:00:00

abstract：AIMS:To investigate the clinical characteristics, laboratory findings and high- resolution CT (HRCT) features and to explore the risk factors for in-hospital death and complications of coronavirus disease 2019 (COVID-19) patients with diabetes. METHODS:From Dec 31, 2019, to Apr 5, 2020, a total of 132 laboratory-confi...

journal_title：Diabetes research and clinical practice

authors： Li Y,Han X,Alwalid O,Cui Y,Cao Y,Liu J,Gu J,Wang L,Fan Y,Shi H

更新日期：2020-08-01 00:00:00

abstract：:Islet amyloid polypeptide (IAPP/Amylin) is a novel peptide which was extracted from islet amyloid deposits in patients with non-insulin-dependent diabetes mellitus (NIDDM). However, its pattern of secretions and plasma concentrations under various conditions has not yet been made clear enough. In this study, we examin...

journal_title：Diabetes research and clinical practice

authors： Hanabusa T,Kubo K,Oki C,Nakano Y,Okai K,Sanke T,Nanjo K

更新日期：1992-01-01 00:00:00

abstract：:Both elevated liver enzymes and a family history of diabetes mellitus (FHDM) are independent risk factors for type 2 diabetes. This study evaluates the epidemiological association between elevated liver enzymes and FHDM. Subjects included 3512 women workers without diabetes, hepatitis, a smoking habit, or a history of...

journal_title：Diabetes research and clinical practice

authors： Inoue K,Matsumoto M,Miyoshi Y,Kobayashi Y

更新日期：2008-03-01 00:00:00

abstract：:This systematic review with meta-analysis examined whether lifestyle modification (diet and/or exercise) is effective for glycemic control in adults with type 2 diabetes in Southeast Asia. Results showed that lifestyle modification is effective in the short term (3months), but not over the longer term (6months) in thi...

journal_title：Diabetes research and clinical practice

authors： Htoo ZW,Hsu WW,Rosenkranz R

更新日期：2016-12-01 00:00:00

abstract：AIMS:Type1 diabetes is generally regarded as an abruptly presenting disease in children without family history. The incidence and prevalence of insulin requiring diabetes in adults is unclear. The aim of this study was to clarify this issue by examining the epidemiology of type 1 diabetes diagnosed in adulthood in a co...

journal_title：Diabetes research and clinical practice

authors： Thordardottir TH,Hreidarsson AB,Benediktsson R

更新日期：2019-05-01 00:00:00

abstract：:The prevalence of obesity observed in this study seems higher than that reported in the previous study. This is probably due to the characteristics of the subjects studied, since they were subjects admitted for health examinations with possible selection. However, the observation in this study clearly indicated that o...

journal_title：Diabetes research and clinical practice

authors： Sasaki A

更新日期：1990-01-01 00:00:00

abstract：AIMS:To evaluate the impact of gestational diabetes mellitus (GDM) and maternal height on offspring birthweight. METHODS:This is an observational cohort study, encompassing 4 111 Finnish primiparous women from Vantaa city, Finland, with singleton deliveries between 2009 and 2015. Data were obtained from the Finnish Me...

journal_title：Diabetes research and clinical practice

authors： Masalin S,Laine MK,Kautiainen H,Gissler M,Raina M,Pennanen P,Eriksson JG

更新日期：2019-02-01 00:00:00

abstract：:There is accumulating evidence that insulin resistance in the pre-diabetic state is associated with the presence of additional cardiovascular risk factors and increased incidence of cardiovascular disease (CVD). There is also accumulating evidence indicating that chronic sub-clinical inflammation as measured by such i...

journal_title：Diabetes research and clinical practice

authors： Haffner SM

更新日期：2003-07-01 00:00:00

abstract：:Increased erythrocyte (RBC) sodium-lithium (Na-Li) counter transport (CT) has been reported to be a genetic marker for essential hypertension (EHT). In addition, increased RBC Na-Li CT has been demonstrated in insulin-dependent diabetic (IDDM) patients with nephropathy, indicating that a predisposition to hypertension...

journal_title：Diabetes research and clinical practice

authors： Senda T,Serizawa N,Negishi K,Katayama S

更新日期：1996-03-01 00:00:00

abstract：:We have quantitatively assessed the percentage of lower limb arterio-venous (a-v) shunting using a radioisotopic technique and correlated it with autonomic neuropathy evaluated by cardiovascular tests. We have studied three groups of diabetic patients: Group A, 12 non-neuropathic subjects without foot lesions; Group B...

journal_title：Diabetes research and clinical practice

authors： Uccioli L,Mancini L,Giordano A,Solini A,Magnani P,Manto A,Cotroneo P,Greco AV,Ghirlanda G

更新日期：1992-05-01 00:00:00

abstract：AIM:To identify characteristics of suboptimally controlled patients with type 2 diabetes (T2DM) on basal insulin treatment who may benefit from intensive titration or further intensification of treatment. METHODS:A post hoc analysis of SOLVE: a 24-week, international, observational study conducted in 17,374 patients w...

journal_title：Diabetes research and clinical practice

authors： Khunti K,Damci T,Husemoen LL,Babu V,Liebl A

更新日期：2017-01-01 00:00:00

abstract：:There are scant data from African populations on the association between beta-cell function and response to treatment with oral hypoglycaemic agents in Type 2 diabetes mellitus (T2DM). Fasting plasma C-peptide (FCP) and glucagon-stimulated C-peptide (GSCP) levels were measured in 116 Nigerians with T2DM at a universit...

journal_title：Diabetes research and clinical practice

authors： Oli JM,Adeyemo AA,Okafor GO,Ofoegbu EN,Onyenekwe B,Chukwuka CJ,Chen G,Chen Y,Doumatey AP,Aje TO,Rotimi CN

更新日期：2005-08-01 00:00:00

abstract：AIMS:Previously we revealed the effectiveness of a new therapeutic approach with a short-term, very-low dose fluvastatin-valsartan combination on the improvement of arterial function in type 1 diabetes mellitus patients (T1DM). In this study we explored whether this approach influences inflammation and oxidative stress...

journal_title：Diabetes research and clinical practice

authors： Lunder M,Janić M,Savić V,Janež A,Kanc K,Šabovič M

更新日期：2017-05-01 00:00:00

abstract：:We examined cross-sectional associations of sex hormone binding globulin (SHBG) with glucose among women recent GDM (n=55). SHBG was associated with fasting glucose levels before and after adjustment for covariates (p=0.015), but not with 2-h glucose. We conclude SHBG should be explored in prospective studies in GDM w...

journal_title：Diabetes research and clinical practice

authors： Kim C,Sen A,Osborne E,Lee JM,Richardson CR

更新日期：2011-09-01 00:00:00