当前位置： SCI文献检索 > DIABETES RESEARCH AND CLINICAL PRACTICE期刊下所有文献 > Long-term therapeutic effects of voglibose, a potent intestinal alpha-glucosidase inhibitor, in spontaneous diabetic GK rats.

Long-term therapeutic effects of voglibose, a potent intestinal alpha-glucosidase inhibitor, in spontaneous diabetic GK rats.

Abstract：

:The effect of long-term (6 months) administration of voglibose in a dietary mixture (10 ppm) on intestinal disaccharidase activity was examined in non obese type 2 diabetes model Goto-Kakizaki (GK) rats. The postprandial blood glucose level in voglibose-treated GK rats was significantly lower than in untreated GK rats (190+/-19 vs. 250+/-25 mg/dl, P<0.01; 1 h, 212+/-23 vs. 256+/-20, P<0.05; 2 h), and the activities of maltase, sucrase, and isomaltase remained significantly lower throughout the 6 months of voglibose treatment. The expressions of protein and mRNA of sucrase-isomaltase (SI) complex were significantly higher in voglibose-treated GK rats. Voglibose administration then was stopped after 6 months of treatment. The mRNA level and protein level of the SI complex became normalized during the interruption of drug administration, and disaccharidase activities increased almost to the level of the untreated group 1 month after treatment was stopped. After 1 day of re-administration of the drug, however, disaccharidase activities again became significantly inhibited. These results indicate that voglibose may improve glucose tolerance since it inhibits activities of disaccharidases in spite of increasing the expression of them on intestine, furthermore voglibose may be reversible and reproducible through interruption and re-administration.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Yasuda K,Shimowada K,Uno M,Odaka H,Adachi T,Shihara N,Suzuki N,Tamon A,Nagashima K,Hosokawa M,Tsuda K,Seino Y

doi

10.1016/s0168-8227(02)00241-3

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

113-22

issue

2

eissn

0168-8227

issn

1872-8227

pii

S0168822702002413

journal_volume

59

pub_type

杂志文章

相关文献

DIABETES RESEARCH AND CLINICAL PRACTICE文献大全
  • Validation of low-cost smartphone-based thermal camera for diabetic foot assessment.

    abstract：AIMS:Infrared thermal imaging (IR) is not yet routinely implemented for early detection of diabetic foot ulcers (DFU), despite proven clinical effectiveness. Low-cost, smartphone-based IR-cameras are now available and may lower the threshold for implementation, but the quality of these cameras is unknown. We aim to val...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2019.01.032

    authors： van Doremalen RFM,van Netten JJ,van Baal JG,Vollenbroek-Hutten MMR,van der Heijden F

    更新日期：2019-03-01 00:00:00

  • Possible link of pioglitazone with bladder cancer in Japanese patients with type 2 diabetes.

    abstract：:We retrospectively examined the frequency of bladder cancer in Japanese patients with type 2 diabetes in relation to use of pioglitazone. Among a total of 663 patients identified to be taking pioglitazone, 9 had bladder cancer (1.36%). Overall the hazard ratio of 1.75 [95% CI: 0.89-3.45] for pioglitazone for bladder c...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2012.11.013

    authors： Fujimoto K,Hamamoto Y,Honjo S,Kawasaki Y,Mori K,Tatsuoka H,Matsuoka A,Wada Y,Ikeda H,Fujikawa J,Koshiyama H

    更新日期：2013-02-01 00:00:00

  • Decreased carbohydrate intake is more important than increased fat intake in the glucose intolerance by a low-carbohydrate/high-fat diet.

    abstract：:A low-carbohydrate/high-fat evening meal impaired the glucose tolerance of healthy subjects to almost the same extent as the impairment caused by overnight fasting. This suggests that the decreased component (carbohydrate) is more relevant than the increased component (fat) to the impairment of glucose tolerance by a ...

    journal_title：Diabetes research and clinical practice

    pub_type： 信件

    doi：10.1016/s0168-8227(01)00291-1

    authors： Wang Y,Kaneko T,Wang PY,Sato A

    更新日期：2002-01-01 00:00:00

  • A polymorphism (D20S32e) close to the human melanocortin receptor 3 is associated with insulin resistance but not the metabolic syndrome.

    abstract：:Insulin resistance (IR) is postulated to underlie diabetes, the metabolic syndrome (MS) and cardiovascular disease (CVD). The D20S32e marker close to the melanocortin receptor-3 (hMC3-R) has been shown to be associated with IR in a large New Zealand Māori kindred, a population at high risk for MS and CVD. Here we exam...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2007.11.002

    authors： Wong J,Nock NL,Xu Z,Kyle C,Daniels A,White M,Yue DK,Elston RC,Mountjoy KG

    更新日期：2008-05-01 00:00:00

  • Influence of intensified insulin regimen on quality of life and metabolic control in insulin-dependent diabetes mellitus.

    abstract：:Seventy-eight non-randomized patients with IDDM, aged 33.8 +/- 9.6 years (mean +/- S.D.), with a duration of diabetes of 16.6 +/- 9.5 years and a HbA1c level of 8.0% +/- 1.5 at baseline were included in the study. The effects of a change from a 3-dose insulin regimen using conventional syringes to a treatment mode usi...

    journal_title：Diabetes research and clinical practice

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/0168-8227(94)90036-1

    authors： Karlson B,Agardh CD

    更新日期：1994-09-01 00:00:00

  • Hospital admissions, emergency department utilisation and patient activation for self-management among people with diabetes.

    abstract：AIMS:To assess the relationship between patient activation for self-management and admissions to hospital or attendances at emergency departments among people with diabetes, after controlling for other known associations. METHODS:Patients were randomly selected from Australia's National Diabetes Services Scheme and in...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2011.05.031

    authors： Begum N,Donald M,Ozolins IZ,Dower J

    更新日期：2011-08-01 00:00:00

  • Impact of hypertension, overall obesity and abdominal obesity on diabetes incidence in Shanghai residents with different glucose levels.

    abstract：:The impact of hypertension, overall obesity and abdominal obesity, individually or collectively, on diabetes incidence over a period of 5 years in residents with different glucose levels is diverse, with abdominal obesity having an impact in both non-diabetic hyperglycaemia and normal groups. ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2011.08.018

    authors： Qian Q,Li X,Feng B

    更新日期：2012-06-01 00:00:00

  • Prevalence of chronic complications in Japanese diabetic patients.

    abstract：:In November 1990, we carried out a survey of chronic complications of diabetes in more than 2000 diabetic patients who were seen on one day in 35 medical institutions including university hospitals, other hospitals and small clinics. More than 60% were aged 55-74 years. About 7% of patients had IDDM. Hypertension was ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(94)90244-5

    authors： Kuzuya T,Akanuma Y,Akazawa Y,Uehata T

    更新日期：1994-10-01 00:00:00

  • Short sleep duration and type 2 diabetes enhance the risk of cardiovascular events in hypertensive patients.

    abstract：AIMS:We tested the hypothesis that short sleep duration is not only a risk factor for diabetes, but that the two conditions in combination would be associated with the risk of incident cardiovascular disease (CVD). METHODS:We analyzed 1255 hypertensive patients (mean age: 70.4±9.9 years) with (N=299) and without diabe...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2012.09.014

    authors： Eguchi K,Hoshide S,Ishikawa S,Shimada K,Kario K

    更新日期：2012-12-01 00:00:00

  • Diabetic neuropathy in Mauritius: prevalence and risk factors.

    abstract：:The study of diabetic neuropathy has been primarily in Europids, despite the high prevalence of diabetes in other populations. We set out to ascertain the prevalence of diabetic neuropathy and its risk factors in the island nation of Mauritius. Population surveys were carried out in 1987 and 1992 in Mauritius to estab...

    journal_title：Diabetes research and clinical practice

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8227(98)00100-4

    authors： Shaw JE,Hodge AM,de Courten M,Dowse GK,Gareeboo H,Tuomilehto J,Alberti KG,Zimmet PZ

    更新日期：1998-11-01 00:00:00

  • A call for inclusion of work-related diabetes distress in the spectrum of diabetes management: Results from a cross-sectional survey among working people with type 1 diabetes.

    abstract：AIM:Diabetes distress captures a range of emotional responses and reactions to life with diabetes and is considered a part of the experience of managing diabetes and its treatment. Given the importance of the social context of work life for people of working age we set out to explore whether work-related diabetes distr...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2018.03.040

    authors： Hansen UM,Olesen K,Browne JL,Skinner TC,Willaing I

    更新日期：2018-06-01 00:00:00

  • Transplantation of discordant pig islet xenografts in diabetic rats.

    abstract：:Xenotransplantation of pig islets under the kidney capsule (KC) of diabetic rats was performed. Natural preformed ACI rat anti-pig leukocytotoxicity, leukoagglutination and hemagglutination antibody titers ranged from Neat-1: 16, 1:8-1:32 and 1:128-1:256, respectively (n = 14). Normal ACI sera were non-toxic to pig is...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(92)90025-m

    authors： Tze WJ,Tai J,Cheung SS

    更新日期：1992-03-01 00:00:00

  • Effects of aldehyde-modified proteins on mesangial cell-matrix interaction.

    abstract：:We examined the effect of aldehyde-modified matrix macromolecules on mesangial cell function in vitro, using incubated rat glomerular mesangial cells. Laminin and fibronectin were modified by incubation for 24 h with 50 mM glycolaldehyde (GA), a highly reactive cross-linking glycation product, with or without equimola...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(94)90123-6

    authors： Hasegawa G,Nakano K,Tsutsumi Y,Kondo M

    更新日期：1994-02-01 00:00:00

  • Metformin in combination with various insulin secretagogues in type 2 diabetes and associated risk of cardiovascular morbidity and mortality--a retrospective nationwide study.

    abstract：AIMS:Metformin is the first-line treatment for most patients with type 2 diabetes but many patients need additional treatment with insulin secretagogues (IS) to achieve glycemic control. We aimed to compare mortality and cardiovascular risk among users of metformin in combination with pharmacologically different ISs. ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2014.09.047

    authors： Mogensen UM,Andersson C,Fosbøl EL,Schramm TK,Vaag A,Scheller NM,Torp-Pedersen C,Gislason G,Køber L

    更新日期：2015-01-01 00:00:00

  • Incidence of children with slowly progressive form of type 1 diabetes detected by the urine glucose screening at schools in the Tokyo Metropolitan Area.

    abstract：:We investigated the incidence of the slowly progressive form of type 1 diabetes (SPT1D) detected by the urine glucose-screening tests at schools in the Tokyo Metropolitan Area from 1974 to 2004. During this study period, a total of 9,242,259 school students underwent the screening program. Of them, 54 children, 19 mal...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.diabres.2008.01.029

    authors： Urakami T,Suzuki J,Yoshida A,Saito H,Mugishima H

    更新日期：2008-06-01 00:00:00

  • Glucose variability, blood pressure and arterial stiffness in type 1 diabetes.

    abstract：AIMS:Evidence suggests that chronic hyperglycaemia predicts not only microvascular disease but also macrovascular disease, however it is not known whether it is the glucose variability per se or the total glucose exposure that confers risk. The objective of this study was to investigate whether daily glucose variabilit...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2008.01.010

    authors： Gordin D,Rönnback M,Forsblom C,Mäkinen V,Saraheimo M,Groop PH

    更新日期：2008-06-01 00:00:00

  • Development and validation of PRISM: a survey tool to identify diabetes self-management barriers.

    abstract：AIMS:Although most children with type 1 diabetes do not achieve optimal glycemic control, no systematic method exists to identify and address self-management barriers. This study develops and validates PRISM (Problem Recognition in Illness Self-Management), a survey-based tool for efficiently identifying self-managemen...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2014.01.015

    authors： Cox ED,Fritz KA,Hansen KW,Brown RL,Rajamanickam V,Wiles KE,Fate BH,Young HN,Moreno MA

    更新日期：2014-04-01 00:00:00

  • miR-221-3p and miR-222-3p downregulation promoted osteogenic differentiation of bone marrow mesenchyme stem cells through IGF-1/ERK pathway under high glucose condition.

    abstract：OBJECTIVE:This study aims to investigate the roles of miR-221-3p and miR-222-3p in the regulation of osteogenic differentiation of bone marrow mesenchyme stem cells (BMSCs) under high glucose condition. MATERIALS AND METHODS:The expreesions of miR-221-3p, miR-222-3p and insulin-like growth factor 1 (IGF-1) were detect...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108121

    authors： Gan K,Dong GH,Wang N,Zhu JF

    更新日期：2020-09-01 00:00:00

  • Genetic markers of immunoglobulins and diabetes mellitus in the multiracial population of New Caledonia. The CALDIA Study Group.

    abstract：:GM and KM immunoglobulin allotypes, which are the markers, respectively, of the constant parts of the heavy and the light chains of the IgG1, IgG2 and IgG3 subclasses, have been analysed in diabetic mellitus patients and controls living in New Caledonia. We tested 40 Europeans, 256 Melanesians and 44 Polynesians, as w...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(99)00125-4

    authors： Dugoujon JM,Guitard E,Sénégas MT,Roth MP,Sanchez A,Barny S,Simon D,Papoz L

    更新日期：2000-03-01 00:00:00

  • Association of the adiponectin gene rs1501299 G>T variant, serum adiponectin levels, and the risk of coronary artery disease in a Chinese population.

    abstract：BACKGROUND:The present study aimed to investigate whether the single nucleotide polymorphism (SNP) 276G>T (rs1501299) of the adiponectin (ADIPOQ) gene was associated with the risk of coronary artery disease (CAD) and serum adiponectin levels in a Chinese population. METHODS:The rs1501299 polymorphism of the ADIPOQ gen...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2012.05.011

    authors： Gui MH,Li X,Jiang SF,Gao J,Lu DR,Gao X

    更新日期：2012-09-01 00:00:00

  • Combined effect of exogenous insulin and sucrose on alterations in plasma lipoproteins induced by cholesterol feeding in the rat.

    abstract：:We have recently reported increased cholesterol concentrations in high-density and very-low-density lipoproteins (HDL and VLDL) in sucrose-fed rats with exogenous hyperinsulinemia. In order to see if exogenous hyperinsulinemia has any effect on the alterations in plasma lipoproteins induced by cholesterol feeding, we ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(89)90032-6

    authors： Kazumi T,Yoshino G,Kasama T,Iwatani I,Tanaka T,Baba S

    更新日期：1989-04-01 00:00:00

  • Effect of Sanguis draconis (a dragon's blood resin) on streptozotocin- and cytokine-induced β-cell damage, in vitro and in vivo.

    abstract：:The study was to examine the effects of Sanguis draconis ethanol extract (SDEE) on streptozotocin (STZ)- and cytokine-induced β-cell damage. In vitro, SDEE did not cause cytotoxicity below 200 μg/ml, and can prevent STZ (5mM)-induced cell death and apoptosis below 100 μg/ml on RIN-m5F cells. SDEE inhibits IL-1β/IFN-γ-...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2011.08.014

    authors： Hu CM,Li JS,Cheah KP,Lin CW,Yu WY,Chang ML,Yeh GC,Chen SH,Cheng HW,Choy CS

    更新日期：2011-12-01 00:00:00

  • Plasma retinol-binding protein is unlikely to be a useful marker of insulin resistance.

    abstract：:To assess whether plasma retinol-binding protein (RBP) is a marker of insulin resistance we measured RBP, insulin and glucose in 285 fasting subjects attending a Lipid Disorders Clinic as outpatients. They were grouped as either subjects without diabetes mellitus and with varying degrees of insulin resistance or subje...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2007.12.002

    authors： Lewis JG,Shand BI,Elder PA,Scott RS

    更新日期：2008-04-01 00:00:00

  • Patient decisional needs when considering treatment intensification for type 2 diabetes: A qualitative study in China.

    abstract：AIMS:This study explored decisional needs of patients with type 2 diabetes in China when considering treatment intensification to achieve good glycemic control, from both the patient's and practitioners' perspectives. METHODS:Interviews were conducted with 35 patients, and individual interviews and focus groups with 2...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108471

    authors： Zheng H,Toupin-April K,An Y,He S,Sigal RJ,Coyle D,Wells GA,Li G

    更新日期：2020-12-01 00:00:00

  • Prevention of type 2 diabetes: a review.

    abstract：:One of the major public health challenges of the 21st century is type 2 diabetes. WHO estimates that by 2025 as many as 200-300 million people worldwide will have developed the disease. A distressing increase in children is perhaps the most alarming sign of something going wrong. Roughly half of the risk of type 2 dia...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabres.2006.09.020

    authors： Hussain A,Claussen B,Ramachandran A,Williams R

    更新日期：2007-06-01 00:00:00

  • Increased angiopoietin-like protein 8 levels in patients with type 2 diabetes and cardiovascular disease.

    abstract：:In the present study, we recruited 124 patients with type 2 diabetes, among which 22 had a history of cardiovascular disease (CVD). The study demonstrated that compared with type 2 diabetes without CVD, those with CVD had remarkably higher levels of angiopoietin-like protein 8 (ANGPTL8). Moreover, the close relationsh...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2016.08.017

    authors： Huang Y,Fang C,Guo H,Hu J

    更新日期：2016-10-01 00:00:00

  • Impaired fasting glucose and risk of diabetes in Taiwan: follow-up over 3 years.

    abstract：:The purpose of this paper was to examine the relationship between fasting glucose levels and development of diabetes among residents of Penghu, Taiwan. From July 1995 to June 1996, a population-based cohort study was conducted among residents aged >or=40 years on the island of Penghu, Taiwan. Of the 1601 surveyed, 130...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(03)00037-8

    authors： Chen KT,Chen CJ,Gregg EW,Imperatore G,Narayan KM

    更新日期：2003-06-01 00:00:00

  • Changes in the TNF-alpha/IL-10 ratio in hyperglycemia-associated pregnancies.

    abstract：AIMS:TNF-α is a diabetogenic cytokine associated with adverse outcomes during pregnancy that can be counterbalanced by IL-10. We have investigated IL-10 and TNF-α balance at maternal and placental levels in hyperglycemia-associated pregnancies. METHODS:One hundred and ninety-two pregnant women participated, which incl...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2015.01.005

    authors： Moreli JB,Corrêa-Silva S,Damasceno DC,Sinzato YK,Lorenzon-Ojea AR,Borbely AU,Rudge MV,Bevilacqua E,Calderon IM

    更新日期：2015-03-01 00:00:00

  • Effect of Sanguis draxonis (a Chinese traditional herb) on the formation of insulin resistance in rats.

    abstract：:Sanguis draxonis (SD) is a Chinese traditional herb that is prescribed for the handling of diabetic disorders. In this study, the effects of an oral administration of SD at dosages of 100, 300, and 500 mg kg(-1) once a day, respectively, on the formation of insulin resistance were investigated in vivo in two models of...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2004.08.011

    authors： Hou Z,Zhang Z,Wu H

    更新日期：2005-04-01 00:00:00

  • Continuous subcutaneous insulin infusion (CSII) and insulin antibodies in rabbits.

    abstract：:Using prepubertal male New Zealand White rabbits, continuous subcutaneous insulin infusion (CSII), delivered by either an external or an implantable infusion device, resulted in significantly higher insulin antibody (I-Ab) production than bolus injection (BII). We tested the influence during CSII of (1) the insulin sp...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(91)90129-2

    authors： Antony G,Cooper SG,Svejkar LC

    更新日期：1991-04-01 00:00:00