Effects of aldehyde-modified proteins on mesangial cell-matrix interaction.

Abstract:

:We examined the effect of aldehyde-modified matrix macromolecules on mesangial cell function in vitro, using incubated rat glomerular mesangial cells. Laminin and fibronectin were modified by incubation for 24 h with 50 mM glycolaldehyde (GA), a highly reactive cross-linking glycation product, with or without equimolar aminoguanidine. GA-modified laminin and fibronectin caused marked inhibition of cell adhesion. Cell spreading was reduced on the GA-modified laminin. In contrast, the GA-modified fibronectin had no effect on cell spreading. The study of thymidine incorporation by mesangial cells showed that the GA-modified fibronectin had a diminished mitogenic activity against cells. The content of advanced glycation end-product (AGE), which was determined by fluorescence at 370 nm excitation and 440 nm emission wavelength, increased and intermolecular cross-links appeared in the GA-modified proteins. To a large extent, aminoguanidine restored the structural alterations and functional deteriorations described above. We conclude that GA-modified matrix proteins diminish their functional properties against mesangial cells and affect cellular functions.

authors

Hasegawa G,Nakano K,Tsutsumi Y,Kondo M

doi

10.1016/0168-8227(94)90123-6

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

25-32

issue

1

eissn

0168-8227

issn

1872-8227

pii

0168-8227(94)90123-6

journal_volume

23

pub_type

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