Effects of aldehyde-modified proteins on mesangial cell-matrix interaction.


:We examined the effect of aldehyde-modified matrix macromolecules on mesangial cell function in vitro, using incubated rat glomerular mesangial cells. Laminin and fibronectin were modified by incubation for 24 h with 50 mM glycolaldehyde (GA), a highly reactive cross-linking glycation product, with or without equimolar aminoguanidine. GA-modified laminin and fibronectin caused marked inhibition of cell adhesion. Cell spreading was reduced on the GA-modified laminin. In contrast, the GA-modified fibronectin had no effect on cell spreading. The study of thymidine incorporation by mesangial cells showed that the GA-modified fibronectin had a diminished mitogenic activity against cells. The content of advanced glycation end-product (AGE), which was determined by fluorescence at 370 nm excitation and 440 nm emission wavelength, increased and intermolecular cross-links appeared in the GA-modified proteins. To a large extent, aminoguanidine restored the structural alterations and functional deteriorations described above. We conclude that GA-modified matrix proteins diminish their functional properties against mesangial cells and affect cellular functions.


Hasegawa G,Nakano K,Tsutsumi Y,Kondo M




Has Abstract


1994-02-01 00:00:00














  • The human red blood cell glyoxalase system in diabetes mellitus.

    abstract::Methylglyoxal and other alpha-oxoaldehydes are formed from glycolytic intermediates and may be involved in the development of diabetic microangiopathy. Glyoxalase I and glyoxalase II metabolise methylglyoxal to D-lactic acid, via the intermediate S-D-lactoylglutathione. The activities of the glyoxalase enzymes and the...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Thornalley PJ,Hooper NI,Jennings PE,Florkowski CM,Jones AF,Lunec J,Barnett AH

    更新日期:1989-08-01 00:00:00

  • The mechanism of exaggerated glucagon response to arginine in diabetes mellitus.

    abstract::As far as exaggerated arginine-induced glucagon secretion in diabetics is concerned, the authors have shown that both the restoration of blood glucose excursions and physiological insulinemia in response to arginine, obtained from an artificial endocrine pancreas (AEP) could normalize the glucagon secretory responses ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Kawamori R,Shichiri M,Kikuchi M,Yamasaki Y,Abe H

    更新日期:1985-10-01 00:00:00

  • Insulin administration may trigger pancreatic beta-cell destruction in patients with type 2 diabetes.

    abstract::Insulin administration causes various types of immune response to insulin. However, there have been no reports that insulin administration triggers pancreatic beta-cell destruction in diabetic patients. We evaluated three patients who had suffered from type 2 diabetes or impaired glucose tolerance for 5-30 years. Afte...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Nakamura M,Nishida W,Yamada Y,Chujo D,Watanabe Y,Imagawa A,Hanafusa T,Kawasaki E,Onuma H,Osawa H,Makino H

    更新日期:2008-02-01 00:00:00

  • Fat mass threshold associated with a significant deterioration of insulin sensitivity in postmenopausal women.

    abstract::The aim of this study was to establish a cut-off value of percentage of fat mass (%FM) at which insulin sensitivity (IS) is significantly altered in sedentary postmenopausal women. Our results suggest that maintaining a %FM below 41% would minimize the deterioration of IS and its associated risks. ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Bobeuf F,Aubertin-Leheudre M,Lord C,Labonté M,Khalil A,Dionne IJ

    更新日期:2010-04-01 00:00:00

  • High prevalence of both anti-insulin and anti-insulin receptor antibodies in Korean patients with insulin autoimmune syndrome.

    abstract::We performed a retrospective pooled analysis of 28 patients who had been diagnosed with insulin autoimmune syndrome and evaluated the prevalence of anti-insulin receptor antibodies. Dual positivity for anti-insulin and anti-insulin receptor antibodies was common (53.8%). However, these patients had a similar phenotype...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Kim SW,Won HK,Seok H,Lee BW,Jung CH,Lee WJ,Kim JH

    更新日期:2012-11-01 00:00:00

  • Feasibility, reliability and validity of the Iranian version of the Diabetes Quality of Life Brief Clinical Inventory (IDQOL-BCI).

    abstract:AIMS:To validate and culturally adapt the Diabetes-specific Quality of Life Brief Clinical Inventory (DQOL-BCI) for the Iranian population. METHODS:After translation - back translation, content validity was assessed utilizing a panel of six experts. Based on a sample of 180 diabetic patients referred to two Diabetics ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Mirfeizi M,Jafarabadi MA,Toorzani ZM,Mohammadi SM,Azad MD,Mohammadi AV,Teimori Z

    更新日期:2012-05-01 00:00:00

  • Increased levels of aldose reductase in peripheral mononuclear cells from type 2 diabetic patients with microangiopathy.

    abstract::Aldose reductase (AR) protein was measured in peripheral mononuclear cells (PMCs) from 55 patients with type 2 diabetes by a two-site ELISA using anti-human AR monoclonal antibody. AR levels did not correlate with age, duration of diabetes, and HbAlc. Furthermore, no significant differences were found in AR levels bet...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Hasegawa G,Obayashi H,Kitamura A,Hashimoto M,Shigeta H,Nakamura N,Kondo M,Nishimura CY

    更新日期:1999-08-01 00:00:00

  • Short-term effect of buformin, a biguanide, on insulin sensitivity, soluble fraction of tumor necrosis factor receptor and serum lipids in overweight patients with type 2 diabetes mellitus.

    abstract:AIMS/HYPOTHESIS:The UK Prospective Diabetes Study (UKPDS) showed that biguanide therapy in overweight patients reduced the risk for any diabetes-related endpoint and all-cause mortality. Biguanides lower the blood glucose values without stimulation of insulin release. We have investigated the short-term effect of bufor...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Ohara S,Komatsu R,Matsuyama T

    更新日期:2004-11-01 00:00:00

  • Height at onset of insulin-dependent diabetes mellitus in high- and low-risk countries. Japan and Pittsburgh Childhood Diabetes Research Groups.

    abstract::The relative height at the onset of insulin-dependent diabetes mellitus was recorded in 340 cases from Japan and 191 cases from Pittsburgh, U.S.A. In Pittsburgh, the children diagnosed after puberty were shorter than normal whereas those diagnosed prior to puberty were much taller than normal. However, in Japan, there...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章



    更新日期:1989-04-01 00:00:00

  • Prevalence of sexual disorders in a selection-free diabetic population (JEVIN).

    abstract::There is an extensive literature on sexual disorders among diabetic patients, but a shortage of studies on their prevalence in selection-free populations. In the present trial (JEVIN), 90% of all insulin-treated diabetic patients (IDDM/NIDDM, n = 127/117) aged 16-60 years and living in the city of Jena (100247 inhabit...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Schiel R,Müller UA

    更新日期:1999-05-01 00:00:00

  • Association between alcohol intake amount and prevalence of metabolic syndrome in Korean rural male population.

    abstract::Moderate alcohol consumption is known to be associated with a reduced risk of cardiovascular disease and mortality. However, few studies reported that long-term alcohol drinking may increase the prevalence of central obesity, and cardiovascular disease. We examined the association between metabolic syndrome, nutrition...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Lee MY,Kim MY,Kim SY,Kim JH,Kim BH,Shin JY,Shin YG,Yun JH,Ryu SY,Lee TY,Koh SB,Chung CH

    更新日期:2010-05-01 00:00:00

  • Oral health content in diabetes self-management education programs.

    abstract::Oral health information was included in 89.5% of diabetes education programs in states with high diabetes prevalence compared to 85.9% in low prevalence states (P = 0.22). Comparing the high to low diabetes prevalence states, there were significant differences in odds for responding "yes" to the topics "show patients ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Yuen HK,Marlow NM,Mahoney S,Slate E,Jenkins C,London S

    更新日期:2010-12-01 00:00:00

  • Altered expression of WFS1 and NOTCH2 genes associated with diabetic nephropathy in T2DM patients.

    abstract:AIM:The increased incidence of type 2 diabetes mellitus (T2DM) and the importance of early identification and management of its complications, especially diabetic nephropathy (DN), have spotted the light on genetic factors that increase risk of T2DM and its related nephropathy. The present study aimed at investigating ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Sharaf SA,Kantoush NA,Ayoub DF,Ibrahim AA,Abdelaal AA,Aziz RA,ElHefnawi MM,Ahmed AN

    更新日期:2018-06-01 00:00:00

  • Ethnicity, race, and clinically significant macular edema in the Veterans Affairs Diabetes Trial (VADT).

    abstract:OBJECTIVE:To determine risk factors in clinically significant macular edema (CSME) and if increased CSME in minorities is due to ethnicity or other factors in the Veterans Affairs Diabetes Trial (VADT). METHODS:CSME prevalence based on 7-field stereo fundus photographs in 1268 patients with type 2 diabetes was related...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Emanuele N,Moritz T,Klein R,Davis MD,Glander K,Khanna A,Thottapurathu L,Bahn G,Duckworth W,Abraira C,Veterans Affairs Diabetes Trial Study Group.

    更新日期:2009-11-01 00:00:00

  • Intermediate-density lipoproteins, diabetes and coronary artery disease.

    abstract::The results of various studies suggest that hypertriglyceridaemia is associated with an increased risk of coronary artery disease. It is unclear, however, which particular triglyceride (TG)-rich lipoproteins contribute to the risk. Different types of TG-rich lipoprotein differ in function, composition, size and densit...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审


    authors: Steiner G

    更新日期:1998-07-01 00:00:00

  • Long-term outcomes associated with triple-goal achievement in patients with type 2 diabetes mellitus (T2DM).

    abstract:AIMS:This study was designed to compare the risk of long-term health outcomes, including microvascular, macrovascular complications and mortality, across 4 cohorts: triple-goal, dual-goal, single-goal, and no-goal achievers. METHODS:A retrospective cohort of 53,120 patients with T2DM were identified (97.51% male, 61.4...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Shi Q,Liu S,Krousel-Wood M,Shao H,Fonseca V,Shi L

    更新日期:2018-06-01 00:00:00

  • The effects of muscle activation on postural stability in diabetes mellitus patients with cutaneous sensory deficit in the foot.

    abstract::Activity of the lower leg muscles in response to an unexpected disturbance to upright standing was studied in diabetic patients and non-diabetic matched controls. The diabetic individuals were classified into two groups: diabetic patients with normal cutaneous sensitivity in the foot (n=27) and patients with cutaneous...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Simmons RW,Richardson C

    更新日期:2001-07-01 00:00:00

  • The prevalence of 6 weeks postpartum abnormal glucose tolerance in Caucasian women with gestational diabetes.

    abstract:AIMS:To evaluate the incidence of impaired glucose tolerance (IGT), impaired fasting glucose (IFG) and diabetes in 318 Caucasian women with gestational diabetes (GDM) at 6 weeks postpartum. METHODS:All women had 75g OGTT and the following data were collected: age, height, weight, results of the challenge 50g and diagn...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Ogonowski J,Miazgowski T

    更新日期:2009-06-01 00:00:00

  • Age of diabetes diagnosis and diabetes duration associate with glycated haemoglobin.

    abstract::An earlier age of diagnosis (r=-0.28, p<0.0001) and longer duration of type 2 diabetes (r=0.26, p<0.0001) were each found to correlate with higher HbA1c level, on analysis of a diabetes centre database in people under regular shared care. When combined, these biological variables strongly associate with the current Hb...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Hsieh A,Ong PX,Molyneaux L,McGill MJ,Constantino M,Wu T,Wong J,Yue DK,Twigg SM

    更新日期:2014-04-01 00:00:00

  • Outcome of clinical foot examination in relation to self-perceived health and glycaemic control in a group of urban Tanzanian diabetic patients.

    abstract::Diabetic foot complications were studied in 153 patients at the university clinic in Dar es Salaam (56 insulin treated, 77 treated with oral agents and 20 with diet only). Neuropathy disability and symptoms scores were used to diagnose peripheral neuropathy (PN). Peripheral vascular disease (PVD) was classified as ank...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Wikblad K,Smide B,Bergström A,Kessi J,Mugusi F

    更新日期:1997-09-01 00:00:00

  • TRB3, up-regulated in kidneys of rats with type1 diabetes, mediates extracellular matrix accumulation in vivo and in vitro.

    abstract:AIMS:Fibrosis is the final disorder of most chronic kidney disease including diabetic nephropathy (DN), but the mechanisms are not fully understood. The present study aims to determine whether TRB3 participates in fibrogenesis in DN. METHODS:Type1 diabetes was induced in male Wistar rats via intraperitoneal injection ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Wang W,Sun A,Lv W,Cheng J,Lv S,Liu X,Guan G,Liu G

    更新日期:2014-10-01 00:00:00

  • Exercise capacity in relation to body fat distribution and muscle fibre distribution in elderly male subjects with impaired glucose tolerance, type 2 diabetes and matched controls.

    abstract:BACKGROUND:The aim of this study was to examine the impact of insulin sensitivity and muscle fibre composition to exercise capacity in individuals with type 2 diabetes (T2D), impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). METHODS:Thirty-nine male patients with T2D, 44 male subjects with IGT and 5...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Segerström ÅB,Elgzyri T,Eriksson KF,Groop L,Thorsson O,Wollmer P

    更新日期:2011-10-01 00:00:00

  • The levels of plasma growth arrest-specific protein 6 is associated with insulin sensitivity and inflammation in women.

    abstract:AIMS:Vitamin K-dependent growth arrest-specific protein 6 (Gas6) and its receptors of the TAM (TYRO-3/Axl/Mer) family are ubiquitously expressed in immune, cardiovascular, and reproductive systems. They play pivotal roles of regulating tissue homeostasis via anti-inflammatory effects. Recent studies show that the Gas6/...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Kuo FC,Hung YJ,Shieh YS,Hsieh CH,Hsiao FC,Lee CH

    更新日期:2014-02-01 00:00:00

  • High prevalence of COVID-19-associated diabetic ketoacidosis in UK secondary care.

    abstract::We aim to describe the prevalence of diabetic ketoacidosis (DKA) in individuals admitted to a single centre with COVID-19. We identified 218 individuals hospitalised with COVID-19, of these four fulfilled criteria for DKA (4/218, 1.8%). We conclude DKA is common and severe in individuals hospitalised with COVID-19. ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Goldman N,Fink D,Cai J,Lee YN,Davies Z

    更新日期:2020-08-01 00:00:00

  • The association between sleep and diabetes outcomes - A systematic review.

    abstract:AIM:This study aimed to systematically review the prevalence of diagnosed sleep disorders in people with diabetes and to determine the association between sleep disorders and blood glucose levels and diabetes outcomes. METHODS:We conducted a literature search in the following databases: MEDLINE (Pubmed), EMBASE, CINAH...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Khalil M,Power N,Graham E,Deschênes SS,Schmitz N

    更新日期:2020-03-01 00:00:00

  • Ten-year incidence of diabetic retinopathy and macular edema. Risk factors in a sample of people with type 1 diabetes.

    abstract:AIMS:To determine the 10-year incidence of diabetic retinopathy (DR) and macular edema (DME), and its relationship with its risk factors in a sample of type 1 diabetes mellitus. METHODS:A total of 334 patients without diabetic retinopathy at baseline underwent a 10-year prospective study, the risk factors included: ag...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Romero-Aroca P,Baget-Bernaldiz M,Fernandez-Ballart J,Plana-Gil N,Soler-Lluis N,Mendez-Marin I,Bautista-Perez A

    更新日期:2011-10-01 00:00:00

  • HRT in women with diabetes--review of the effects on glucose and lipid metabolism.

    abstract::Hormone replacement therapy (HRT) is prescribed less frequently to women with diabetes. In this article, we review the effects of HRT on glucose metabolism and plasma lipids in women with type 2 diabetes. Current evidence is reassuring about the effects of HRT in women with diabetes, although as in all women, HRT shou...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审


    authors: Palin SL,Kumar S,Sturdee DW,Barnett AH

    更新日期:2001-11-01 00:00:00

  • Demographic and clinical features of critically ill patients with COVID-19 in Greece: The burden of diabetes and obesity.

    abstract:AIMS:The aim of the study was to investigate the association between type-2 diabetes mellitus, other underlying diseases and obesity with the outcomes of critically ill Covid-19 patients in Greece. METHODS:In this retrospective observational multi-centre study, data and outcomes of 90 RNA 2109-nCoV confirmed criticall...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,多中心研究


    authors: Halvatsiotis P,Kotanidou A,Tzannis K,Jahaj E,Magira E,Theodorakopoulou M,Konstandopoulou G,Gkeka E,Pourzitaki C,Kapravelos N,Papoti S,Sileli M,Gogos C,Velissaris D,Markou N,Stefanatou E,Vlachogianni G,Aimoniotou E,Kom

    更新日期:2020-08-01 00:00:00

  • Outcome of pregnant diabetic patients in Benghazi (Libya) from 1984 to 1991.

    abstract::During the period from 1 June 1984 to 1 June 1991, 988 pregnant diabetic patients were treated by a team of physicians and obstetricians in Benghazi Diabetic Clinic. Twelve patients were insulin-dependent (type 1) and 976 patients were non-insulin-dependent (type 2). Ninety patients were diagnosed for the first time d...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Kadiki OA,Reddy MR,Sahli MA,Shawar H,Rao S

    更新日期:1993-07-01 00:00:00

  • Rising prevalence of type 2 diabetes in rural Bangladesh: a population based study.

    abstract::The aim of the study was to determine the temporal changes in the prevalence of type 2 diabetes mellitus and its associated risk factors in a rural population of Bangladesh. A total of 4757 subjects age >/=20 years both male and female were enrolled randomly in a cross-sectional study in 1999. The same area and popula...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Rahim MA,Hussain A,Azad Khan AK,Sayeed MA,Keramat Ali SM,Vaaler S

    更新日期:2007-08-01 00:00:00