Morphological changes in autonomic ganglionic cells of the heart in diabetic patients.

Abstract:

:To clarify the histological changes of the cardiac autonomic nervous system in diabetes mellitus, ganglionic cells of the hearts of autopsy cases were examined light microscopically. In 7 severely diabetic patients, the ganglionic neurons showed cellular contraction, cytoplasmic condensation and poor staining of Nissl substance. As neuronal alterations were obvious neither in the mild diabetic patients nor in the non-diabetic patients, these alterations therefore seemed to correlate with diabetes mellitus. The neuronal changes did not seem to correlate with major coronary arterial atherosclerotic narrowing.

authors

Tsujimura T,Nunotani H,Fushimi H,Inoue T

doi

10.1016/s0168-8227(86)80014-6

subject

Has Abstract

pub_date

1986-06-01 00:00:00

pages

133-7

issue

3

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(86)80014-6

journal_volume

2

pub_type

杂志文章
  • The rs1801278 G>A polymorphism of IRS-1 is associated with metabolic syndrome in healthy nondiabetic men. Modulation by cigarette smoking status.

    abstract:AIMS:To explore associations between IRS-1 rs1801278 G>A polymorphism and metabolic syndrome (MS). METHODS:rs1801278 G>A was genotyped in 610 healthy Argentinian men. RESULTS:GA carriers had lower risk of MS (OR=0.52, P=0.045), particularly among smokers (OR=0.10, P=0.006). CONCLUSIONS:rs1801278 GA carriers had lowe...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2011.05.018

    authors: Pérez MS,Tellechea ML,Aranguren F,Taverna MJ,Rodríguez RG,Meroño T,Brites F,Poskus E,Frechtel GD

    更新日期:2011-09-01 00:00:00

  • Admission hyperglycemia and radiological findings of SARS-CoV2 in patients with and without diabetes.

    abstract::Diabetes emerged as major risk factor for severe acute respiratory syndrome (SARS) and adverse outcome in patients with the coronavirus disease 2019 (COVID-19). Nevertheless, the role of admission hyperglycemia in patients with COVID-19 has not been well-explored, yet. With this retrospective analysis, we report for t...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2020.108185

    authors: Iacobellis G,Penaherrera CA,Bermudez LE,Bernal Mizrachi E

    更新日期:2020-06-01 00:00:00

  • Protein kinase C-beta inhibition for diabetic kidney disease.

    abstract::Amid the rapidly rising number of people with diabetes worldwide, the prevalence of diabetic kidney disease (DKD) is expected to increase considerably despite available treatments. Consequently, novel therapeutic agents are urgently needed. Ruboxistaurin mesylate is a bisindolylmaleimide that specifically inhibits the...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/j.diabres.2008.09.041

    authors: Tuttle KR

    更新日期:2008-11-13 00:00:00

  • SGLT2 inhibitors with cardiovascular benefits: Transforming clinical care in Type 2 diabetes mellitus.

    abstract::Cardiovascular risk reduction in individuals with Type 2 diabetes mellitus (T2DM) is a key part of clinical management. Sodium-glucose co-transporter (SGLT2) inhibitors improve glycaemic control, reduce body weight and decrease blood pressure. In addition, the SGLT2 inhibitors empagliflozin and canagliflozin reduced t...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/j.diabres.2017.11.023

    authors: d'Emden M,Amerena J,Deed G,Pollock C,Cooper ME

    更新日期:2018-02-01 00:00:00

  • The influence of carbohydrate consumption on glycemic control in pregnant women with type 1 diabetes.

    abstract:AIMS:To study the influence of the quantity and the quality of carbohydrate consumption on glycemic control in early pregnancy among women with type 1 diabetes. METHODS:A retrospective study of 107 women with type 1 diabetes who completed 1-3days of diet recording before first antenatal visit, as a part of routine car...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2016.12.012

    authors: Ásbjörnsdóttir B,Akueson CE,Ronneby H,Rytter A,Andersen JR,Damm P,Mathiesen ER

    更新日期:2017-05-01 00:00:00

  • Decreased carbohydrate intake is more important than increased fat intake in the glucose intolerance by a low-carbohydrate/high-fat diet.

    abstract::A low-carbohydrate/high-fat evening meal impaired the glucose tolerance of healthy subjects to almost the same extent as the impairment caused by overnight fasting. This suggests that the decreased component (carbohydrate) is more relevant than the increased component (fat) to the impairment of glucose tolerance by a ...

    journal_title:Diabetes research and clinical practice

    pub_type: 信件

    doi:10.1016/s0168-8227(01)00291-1

    authors: Wang Y,Kaneko T,Wang PY,Sato A

    更新日期:2002-01-01 00:00:00

  • Continuous subcutaneous insulin infusion does not correspond with pregnancy outcomes despite better glycemic control as compared to multiple daily injections in type 1 diabetes - Significance of pregnancy planning and prepregnancy HbA1c.

    abstract:OBJECTIVE:The aim of the study was to compare pregnancy outcomes with glycemic control, total increase in insulin requirement, and body weight gain in the women with Type 1 Diabetes Mellitus (T1DM) using continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDI). MATERIAL AND METHODS:This was a...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2020.108628

    authors: Żurawska-Kliś M,Kosiński M,Kuchnicka A,Rurka M,Hałucha J,Wójcik M,Cypryk K

    更新日期:2020-12-22 00:00:00

  • Metformin-related colonic glucose uptake; potential role for increasing glucose disposal?--A retrospective analysis of (18)F-FDG uptake in the colon on PET-CT.

    abstract:AIM:The use of metformin has been associated with diffusely increased colonic (18)F-fluorodeoxyglucose ((18)F-FDG) uptake. Interestingly, metformin use is associated with moderate weight loss. It could be hypothesized that increased colonic glucose disposal is related to this weight loss. It is unknown whether other fa...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2016.02.009

    authors: Bahler L,Stroek K,Hoekstra JB,Verberne HJ,Holleman F

    更新日期:2016-04-01 00:00:00

  • IDL can stimulate atherogenic gene expression in cultured human vascular endothelial cells.

    abstract::Previously, we have reported that the lipoprotein fraction containing intermediate density lipoprotein (IDL) and low density lipoprotein (LDL) isolated from diabetics stimulates an atherogenic cytokine in cultured endothelial cells. To study which lipoprotein fraction isolated from diabetics can modulate the gene expr...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/s0168-8227(99)00147-3

    authors: Maeno Y,Kashiwagi A,Nishio Y,Takahara N,Kikkawa R

    更新日期:2000-05-01 00:00:00

  • Impact of an acceptance facilitating intervention on diabetes patients' acceptance of Internet-based interventions for depression: a randomized controlled trial.

    abstract:AIMS:To (1) determine diabetes patients' acceptance of Internet-based interventions (IBIs) for depression, to (2) examine the effectiveness of an acceptance facilitating intervention (AFI) and to (3) explore subgroup specific effects. METHODS:141 diabetes patients from two inpatient rehabilitation units and one outpat...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.diabres.2014.04.031

    authors: Baumeister H,Nowoczin L,Lin J,Seifferth H,Seufert J,Laubner K,Ebert DD

    更新日期:2014-07-01 00:00:00

  • Changes in prevalence of diabetes over 15 years in a rural Australian population: The Crossroads Studies.

    abstract:AIMS:Secular trends in diabetes prevalence vary globally. We compared the prevalence of diabetes in two surveys 15 years apart in rural Australia. METHOD:Two cross-sectional household surveys and clinics (biomedical assessments including oral glucose tolerance tests (OGTTs)) in 2001-2003 (Crossroads) and 2016-2018 (Cr...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2020.108492

    authors: Simmons D,Glenister K,Magliano DJ,Bourke L

    更新日期:2020-12-01 00:00:00

  • Awareness of pathophysiological concepts of type 2 diabetes: a survey in 847 physicians.

    abstract:AIMS:The aim of the study was to determine physicians' knowledge of specific concepts generally implicated in the pathophysiology of type 2 diabetes (T2D). METHODS:A multiple choice online survey was completed by 847 physicians, of which 516 were engaged in primary care (PCP) and 331 in specialized care (SCP) in the U...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2006.09.037

    authors: Busse FP,Denti V,Stumvoll M

    更新日期:2007-06-01 00:00:00

  • Increased serum miR-7 is a promising biomarker for type 2 diabetes mellitus and its microvascular complications.

    abstract:AIMS:To investigate the alteration pattern and physiologic state of islet-specific miR-7 in the serum of patients with type 2 diabetes mellitus (T2DM) and T2DM-associated microvascular complications (T2DMC) and to evaluate its clinical significance. METHODS:The levels of serum miR-7 were firstly examined and compared ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2017.06.005

    authors: Wan S,Wang J,Wang J,Wu J,Song J,Zhang CY,Zhang C,Wang C,Wang JJ

    更新日期:2017-08-01 00:00:00

  • Efficacy and safety of linagliptin/metformin single-pill combination as initial therapy in drug-naïve Asian patients with type 2 diabetes.

    abstract:AIM:To assess efficacy/safety of initial linagliptin/metformin single-pill combination (SPC) therapies versus individual drug components over 24weeks in treatment-naïve Asian patients with type 2 diabetes mellitus and insufficient glycemic control. METHODS:Patients (initial glycated hemoglobin [HbA1c] ⩾7.5% to <11.0% ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.diabres.2016.11.026

    authors: Mu Y,Pan C,Fan B,Hehnke U,Zhang X,Zhang X,Wang X,Liu J,Zhang Y,Du J,Ma J,Gong Y

    更新日期:2017-02-01 00:00:00

  • Self-monitoring of blood glucose in type 2 diabetes: an inter-country comparison.

    abstract::Self-monitoring of blood glucose (SMBG) in type 2 diabetic patients was compared across 14 countries. There was an unexpectedly high SMBG-use in non-insulin-treated patients. Reimbursement polices differed by country, region, insurance status, and patient income. More rigorous and systematic data collection is needed ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2008.08.021

    authors: SMBG International Working Group.

    更新日期:2008-12-01 00:00:00

  • Nitric oxide system is involved in glomerular hyperfiltration in Japanese normo- and micro-albuminuric patients with type 2 diabetes.

    abstract::Glomerular hyperfiltration plays a pathogenic role in the early stages of diabetic nephropathy. Experimental studies in laboratory animals suggest that nitric oxide (NO) might be involved in the pathogenesis of glomerular hyperfiltration. We performed a cross-sectional study to determine the relationship between diabe...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0168-8227(01)00260-1

    authors: Hiragushi K,Sugimoto H,Shikata K,Yamashita T,Miyatake N,Shikata Y,Wada J,Kumagai I,Fukushima M,Makino H

    更新日期:2001-09-01 00:00:00

  • An immunopotentiator of beta-1,6;1,3 D-glucan prevents diabetes and insulitis in BB rats.

    abstract::The preventive effect of an immunopotentiator, beta-1,6;1,3 D-glucan, on the development of diabetes and insulitis was studied in BB rats. The intravenous administration of 1 mg kg-1 week-1 of beta-1,6;1,3 D-glucan from the age of 4 weeks decreased the cumulative incidence of diabetes from 43.3% (13/30) to 6.7% (2/30)...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/0168-8227(92)90152-h

    authors: Kida K,Inoue T,Kaino Y,Goto Y,Ikeuchi M,Ito T,Matsuda H,Elliott RB

    更新日期:1992-08-01 00:00:00

  • Effects of miglitol, sitagliptin, and initial combination therapy with both on plasma incretin responses to a mixed meal and visceral fat in over-weight Japanese patients with type 2 diabetes. "the MASTER randomized, controlled trial".

    abstract:AIM:To assess changes in circulating incretin levels and body fat compositions with initial combination therapy with α-glucosidase inhibitor and dipeptidyl peptidase-4 inhibitor in patients with type 2 diabetes (T2D). METHODS:In this multicenter open-label 24-week trial, Japanese over-weight (BMI ≥ 25 kg/m(2)) patient...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.diabres.2014.09.040

    authors: Mikada A,Narita T,Yokoyama H,Yamashita R,Horikawa Y,Tsukiyama K,Yamada Y

    更新日期:2014-12-01 00:00:00

  • Insulin inhibits glucagon-induced glycogenolysis normally in perivenous hepatocytes of Wistar fatty rats.

    abstract::Wistar fatty (WF) rats are obese, hyperinsulinemic and hyperglycemic, and thus a model of type 2 diabetes mellitus. Since we have found that insulin specifically inhibits glucagon-induced glycogenolysis in perivenous hepatocytes (PVH) from normal rats, we examined the inhibitory effect of insulin on glucagon-induced g...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2004.12.008

    authors: Ikezawa Y,Yamatani K,Ohnuma H,Daimon M,Manaka H,Sasaki H

    更新日期:2005-08-01 00:00:00

  • Evidence-based management of hyperglycemic emergencies in diabetes mellitus.

    abstract::The hyperglycemic emergencies, diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are potentially fatal complications of uncontrolled diabetes mellitus. The incidence of DKA and the economic burden of its treatment continue to rise, but its associated mortality rate which was uniformly high has dim...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/j.diabres.2011.09.012

    authors: Nyenwe EA,Kitabchi AE

    更新日期:2011-12-01 00:00:00

  • Diabetes among migrants in Denmark: Incidence, mortality, and prevalence based on a longitudinal register study of the entire Danish population.

    abstract:OBJECTIVE:Studies of diabetes in migrant populations have shown a higher prevalence compared to their respective countries of origin and to people natively born in the host country, but there is little population-based data on diabetes incidence and mortality in migrant populations. The aim of the current study was (1)...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2016.09.020

    authors: Andersen GS,Kamper-Jørgensen Z,Carstensen B,Norredam M,Bygbjerg IC,Jørgensen ME

    更新日期:2016-12-01 00:00:00

  • Epidemiology of diabetes mellitus in old age in Japan.

    abstract::Epidemiological studies on diabetes mellitus revealed that the number of patients with diabetes mellitus is gradually increasing in Japan along with development of car society and westernization of food intake. Since prevalence of diabetes mellitus increases with aging, proportion of individuals with diabetes mellitus...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2007.01.070

    authors: Nakano T,Ito H

    更新日期:2007-09-01 00:00:00

  • Abnormal transient rise in hepatic glucose production after oral glucose in non-insulin-dependent diabetic subjects.

    abstract::A transient rise in hepatic glucose production (HGP) after an oral glucosa load has been reported in some insulin-resistant states such as in obese fa/fa Zucker rats. The aim of this study was to determine whether this rise in HGP also occurs in subjects with established non-insulin-dependent diabetes mellitus (NIDDM)...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/0168-8227(95)01067-n

    authors: Thorburn A,Litchfield A,Fabris S,Proietto J

    更新日期:1995-05-01 00:00:00

  • Use of antidepressants and statins and short-term risk of new-onset diabetes among high risk adults.

    abstract:AIMS:We evaluated the association of combined use of antidepressants and statins and the risk of new-onset diabetes among high-risk adults. METHODS:We used a retrospective, observational, longitudinal design among adults (age ≥ 22 years) who were diabetes free at baseline and had reported hypertension or hyperlipidemi...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2014.04.016

    authors: Bhattacharya R,Ajmera M,Bhattacharjee S,Sambamoorthi U

    更新日期:2014-08-01 00:00:00

  • An examination of the covariability of subclinical albuminuria in insulin-dependent diabetes mellitus: implications for monitoring microalbuminuria.

    abstract::We examined the covariability of subclinical albuminuria in a cohort of 160 insulin-dependent diabetics who underwent simultaneous measurements of overnight urinary albumin excretion rate (UAV) and several clinical variables on 7 occasions over a period of 18 months. After allowing for within-patient correlation betwe...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/0168-8227(93)90067-f

    authors: Watts GF,Taub NA,Mazurkiewicz J,Shaw KM

    更新日期:1993-08-01 00:00:00

  • A high thyroid stimulating hormone level is associated with diabetic peripheral neuropathy in type 2 diabetes patients.

    abstract:AIM:The association between thyroid stimulating hormone (TSH) and type 2 diabetes mellitus (T2DM) is well known. However, whether TSH is related to diabetic peripheral neuropathy (DPN) has not been studied. The aim of this study was to explore the relationship between TSH and DPN in Chinese patients with T2DM. METHODS...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2016.01.018

    authors: Zhao W,Zeng H,Zhang X,Liu F,Pan J,Zhao J,Zhao J,Li L,Bao Y,Liu F,Jia W

    更新日期:2016-05-01 00:00:00

  • Acarbose controls postprandial hyperproinsulinemia in non-insulin dependent diabetes mellitus.

    abstract::We investigated how fasting or postprandial insulin levels were altered by treatment with acarbose or sulfonylureas. Plasma glucose and serum insulin, C-peptide, and proinsulin levels were measured before as well as 1 and 2 h after breakfast in 23 patients with non-insulin-dependent diabetes mellitus and 17 patients w...

    journal_title:Diabetes research and clinical practice

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0168-8227(97)00045-4

    authors: Inoue I,Takahashi K,Noji S,Awata T,Negishi K,Katayama S

    更新日期:1997-06-01 00:00:00

  • Decreased A20 mRNA and protein expression in peripheral blood mononuclear cells in patients with type 2 diabetes and latent autoimmune diabetes in adults.

    abstract:AIMS:A20 is a negative regulator of nuclear factor kappa B activation and the central gatekeeper in inflammation and immunity. While its role in type 1 diabetes has been widely studied, its expression level in immune cells from type 2 diabetes (T2D) and latent autoimmune diabetes in adult (LADA) patients remains unclea...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2014.09.014

    authors: Cheng L,Zhang D,Jiang Y,Deng W,Wu Q,Jiang X,Chen B

    更新日期:2014-12-01 00:00:00

  • Predictors of quality of life gains among people with type 1 diabetes participating in the Dose Adjustment for Normal Eating (DAFNE) structured education programme.

    abstract:AIMS:To examine predictors of quality of life gains among people with type 1 diabetes following the Dose Adjustment for Normal Eating (DAFNE) self-management training programme. METHODS:Clinical and questionnaire data were collected from 437 patients from 6 hospital centres before, and 18 months post-DAFNE interventio...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2012.09.017

    authors: Byrne M,Newell J,Coffey N,O' Hara MC,Cooke D,Dinneen SF

    更新日期:2012-11-01 00:00:00

  • The impact of initial antidiabetic agent and use of monitoring agents on prescription costs in newly treated type 2 diabetes: A retrospective cohort analysis.

    abstract:AIMS:To measure the costs associated with the use of antidiabetic agents, monitoring materials and cardiovascular disease (CVD) agents in the management of newly treated type 2 diabetes, and to investigate the factors associated with these costs. METHODS:A population-based retrospective cohort study was conducted usin...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2015.12.020

    authors: Grimes RT,Bennett K,Canavan R,Tilson L,Henman MC

    更新日期:2016-03-01 00:00:00