The rs1801278 G>A polymorphism of IRS-1 is associated with metabolic syndrome in healthy nondiabetic men. Modulation by cigarette smoking status.

Abstract:

AIMS:To explore associations between IRS-1 rs1801278 G>A polymorphism and metabolic syndrome (MS). METHODS:rs1801278 G>A was genotyped in 610 healthy Argentinian men. RESULTS:GA carriers had lower risk of MS (OR=0.52, P=0.045), particularly among smokers (OR=0.10, P=0.006). CONCLUSIONS:rs1801278 GA carriers had lower risk of MS, especially among smokers.

authors

Pérez MS,Tellechea ML,Aranguren F,Taverna MJ,Rodríguez RG,Meroño T,Brites F,Poskus E,Frechtel GD

doi

10.1016/j.diabres.2011.05.018

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

e95-7

issue

3

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(11)00247-6

journal_volume

93

pub_type

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