The effects of lipoic acid and α-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial.


:Antioxidants probably play an important role in the etiology of type 2 diabetes (DM2). This study evaluated the effects of supplementation with lipoic acid (LA) and α-tocopherol on the lipid profile and insulin sensitivity of DM2 patients. A randomized, double-blind, placebo-controlled trial involving 102 DM2 patients divided into four groups to receive daily supplementation for 4 months with: 600 mg LA (n = 26); 800 mg α-tocopherol (n = 25); 800 mg α-tocopherol + 600 mg LA (n = 25); placebo (n = 26). Plasma α-tocopherol, lipid profile, glucose, insulin, and the HOMA index were determined before and after supplementation. Differences within and between groups were compared by ANOVA using Bonferroni correction. Student's t-test was used to compare means of two independent variables. The vitamin E/total cholesterol ratio improved significantly in patients supplemented with vitamin E+LA and vitamin E alone (p ≤ 0.001). There were improvements of the lipid fractions in the groups receiving LA and vitamin E alone or in combination, and on the HOMA index in the LA group, but not significant. The results suggest that LA and vitamin E supplementation alone or in combination did not affect the lipid profile or insulin sensitivity of DM2 patients.


de Oliveira AM,Rondó PH,Luzia LA,D'Abronzo FH,Illison VK




Has Abstract


2011-05-01 00:00:00














  • Cancer survivors: An expanding population with an increased cardiometabolic risk.

    abstract::In the last decades the survival rate of patients diagnosed with cancer - both in childhood and adulthood - significantly improved, leading to a growing number of cancer survivors (CS) within general population. Despite the better survival rate related to the cancer diagnosis, CS show increased mortality and morbidity...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审


    authors: Felicetti F,Fortunati N,Brignardello E

    更新日期:2018-09-01 00:00:00

  • Influence of intensified insulin regimen on quality of life and metabolic control in insulin-dependent diabetes mellitus.

    abstract::Seventy-eight non-randomized patients with IDDM, aged 33.8 +/- 9.6 years (mean +/- S.D.), with a duration of diabetes of 16.6 +/- 9.5 years and a HbA1c level of 8.0% +/- 1.5 at baseline were included in the study. The effects of a change from a 3-dose insulin regimen using conventional syringes to a treatment mode usi...

    journal_title:Diabetes research and clinical practice

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Karlson B,Agardh CD

    更新日期:1994-09-01 00:00:00

  • Glucose tolerance and insulin response in parents of patients with insulin-dependent and juvenile-onset non-insulin-dependent diabetes mellitus.

    abstract::Glucose tolerance and insulin response were examined using a 100 g oral glucose tolerance test (OGTT) in 108 parents of 23 patients with insulin-dependent (IDDM) and 31 patients with non-insulin-dependent diabetes mellitus (NIDDM), whose age of onset of diabetes was less than 35 years. Thirty-two age-matched healthy v...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Matsuda A,Kuzuya T

    更新日期:1992-04-01 00:00:00

  • The evaluation of thiol/disulphide homeostasis in diabetic nephropathy.

    abstract:AIMS:Thiol/disulphide homeostasis plays a critical role in antioxidant defense, and detoxification in body. Although alteration of thiol/disulfide homeostasis had been shown in patients with diabetes, the thiol/disulfide balance in patients with type 2 diabetes and nephropathy is not yet known. METHODS:Twenty-six heal...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Eren MA,Koyuncu İ,İncebıyık H,Karakaş H,Erel Ö,Sabuncu T

    更新日期:2019-02-01 00:00:00

  • Non-high-density lipoprotein cholesterol and risk of cardiovascular disease in the general population and patients with type 2 diabetes: A systematic review and meta-analysis.

    abstract:AIMS:To examine the relationship of non-high-density lipoprotein cholesterol (non-HDL-C) level with cardiovascular disease (CVD) risk in type 2 diabetes patients and the general population by conducting a meta-analysis. METHODS:We made a comprehensive literature search for relevant observational studies investigating ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,meta分析


    authors: Cao Y,Yan L,Guo N,Yu N,Wang Y,Cao X,Yang S,Lv F

    更新日期:2019-01-01 00:00:00

  • Association of sulfonylurea receptor 1 genotype with therapeutic response to gliclazide in type 2 diabetes.

    abstract::To investigate the effects of sulfonylurea receptor 1 (SUR1) exon 33 (TCC-->GCC, S1369A) polymorphism on responsiveness to gliclazide. About 115 patients with type 2 diabetes were treated with gliclazide for 8 weeks. SUR1 genotypes were tested by Taqman-PCR. After gliclazide treatment, there was association between T/...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Zhang H,Liu X,Kuang H,Yi R,Xing H

    更新日期:2007-07-01 00:00:00

  • Intermittent and recurrent hepatomegaly due to glycogen storage in a patient with type 1 diabetes: genetic analysis of the liver glycogen phosphorylase gene (PYGL).

    abstract::We report a 19-year-old woman who had a history of type 1 diabetes with recurrent glycogen accumulation in the liver. During her infantile period she presented with no hepatomegaly nor growth retardation. On admission she was diagnosed with diabetic ketoacidosis (DKA). She also had hepatomegaly and elevated transamina...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Tomihira M,Kawasaki E,Nakajima H,Imamura Y,Sato Y,Sata M,Kage M,Sugie H,Nunoi K

    更新日期:2004-08-01 00:00:00

  • Association of statin use and development of renal dysfunction in type 2 diabetes--the Hong Kong Diabetes Registry.

    abstract:AIM:Dyslipidaemia may be a risk factor for diabetic kidney disease. We examined prospectively association between the use of statins and development of renal dysfunction in type 2 diabetes. METHODS:A consecutive cohort of 5264 diabetic patient recruited between 1996 and 2005 underwent detailed assessments. Renal dysfu...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Luk AO,Yang X,Ma RC,Ng VW,Yu LW,Lau WW,Ozaki R,Chow FC,Kong AP,Tong PC,Chan JC,So W

    更新日期:2010-06-01 00:00:00

  • Use of continuous intravenous insulin infusion in type 1 diabetic pregnancy complicated by nephrotic syndrome.

    abstract::We report a case of nephrotic syndrome complicating pregnancy in a woman with CSII-treated type 1 diabetes. This was associated with deteriorating glycaemic control which was successfully managed with continuous intravenous insulin for the two weeks before delivery. ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Dudding S,Whitelaw D

    更新日期:2011-07-01 00:00:00

  • Health education on diabetes and other non-communicable diseases imparted to teachers shows a cascading effect. A study from Southern India.

    abstract:AIMS:The aims were to assess effect of a short training programme on non-communicable diseases (NCDs), particularly diabetes on school teachers and also on students who were in turn educated by them. Lifestyle changes made by both groups were assessed 6months later. METHODS:Graduate teachers (n=1017) from 2 districts ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Selvam S,Murugesan N,Snehalatha C,Nanditha A,Raghavan A,Simon M,Susairaj P,Ramachandran A

    更新日期:2017-03-01 00:00:00

  • Retrospective analysis of daily glucose profile in type 1 diabetic patients with continuous subcutaneous insulin infusion (CSII).

    abstract::A retrospective analysis of blood glucose control was performed in 17 type 1 diabetic patients who regularly monitored their blood glucose concentration by visual strips over a period of 3-83 months. Analysis was performed by a patient management software loaded on a personal computer. In this cohort of patients the a...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Bruttomesso D,Barberio S,Fongher C,Lisato G,Silvestri B,Briani G,Tiengo A,Del Prato S

    更新日期:1992-06-01 00:00:00

  • Novel deletion mutation in the glucokinase gene from a korean man with GCK-MODY phenotype and situs inversus.

    abstract::A novel mutation in intron 9-exon 10 boundary of the GCK gene was detected in a male patient with clinical features of GCK-MODY and situs inversus. This case highlights the value of sequencing the GCK gene in individuals with GCK-MODY phenotype and no family history of monogenic diabetes. ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Cho YK,Cho EH,Choi HS,Kim SW

    更新日期:2018-09-01 00:00:00

  • A Leu184Val polymorphism in PCK1 gene is associated with type 2 diabetes in Eastern Chinese population with BMI

    abstract::Our previous finding has shown that a suggestive linkage existed in D20S196 in diabetic families with lowered BMI in eastern Chinese population. The aim of this study is to investigate whether variants in PCK1 gene, located in this region, was associated with type 2 diabetes in eastern China. Eleven SNPs were identifi...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Dong Y,Zhang H,Wang X,Feng Q,Chen X,Su Q

    更新日期:2009-02-01 00:00:00

  • Autoantibodies to glutamic acid decarboxylase (GAD), 64,000-Mr islet cell protein (64K) antibodies and islet cell antibodies (ICA) in insulin-dependent diabetes mellitus with and without autoimmune diseases in Japan.

    abstract::IDDM is known to be a heterogeneous disease which is frequently complicated with other autoimmune diseases (AID). We previously reported that IDDM patients with AID were characterized by late onset of diabetes, persistent ICA-positivity and increased association with DR9, while those without AID were characterized by ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Akawaza S,Kawasaki E,Yano M,Abiru N,Yamaguchi Y,Nagataki S

    更新日期:1994-10-01 00:00:00

  • Admission hyperglycemia and radiological findings of SARS-CoV2 in patients with and without diabetes.

    abstract::Diabetes emerged as major risk factor for severe acute respiratory syndrome (SARS) and adverse outcome in patients with the coronavirus disease 2019 (COVID-19). Nevertheless, the role of admission hyperglycemia in patients with COVID-19 has not been well-explored, yet. With this retrospective analysis, we report for t...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Iacobellis G,Penaherrera CA,Bermudez LE,Bernal Mizrachi E

    更新日期:2020-06-01 00:00:00

  • Nitric oxide system is involved in glomerular hyperfiltration in Japanese normo- and micro-albuminuric patients with type 2 diabetes.

    abstract::Glomerular hyperfiltration plays a pathogenic role in the early stages of diabetic nephropathy. Experimental studies in laboratory animals suggest that nitric oxide (NO) might be involved in the pathogenesis of glomerular hyperfiltration. We performed a cross-sectional study to determine the relationship between diabe...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,多中心研究


    authors: Hiragushi K,Sugimoto H,Shikata K,Yamashita T,Miyatake N,Shikata Y,Wada J,Kumagai I,Fukushima M,Makino H

    更新日期:2001-09-01 00:00:00

  • Changing prevalence of retinopathy in newly diagnosed non-insulin dependent diabetes mellitus patients in Hong Kong.

    abstract::In this retrospective study, the prevalence of chronic microangiopathic complications was determined in 474 Chinese patients with non-insulin dependent diabetes mellitus (NIDDM) who presented within 1 year of diagnosis to the diabetes clinic from January 1990 to December 1996. Mean age (+/- S.E.) was 53.6 (+/- 0.6) ye...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Wang WQ,Ip TP,Lam KS

    更新日期:1998-03-01 00:00:00

  • Fat mass threshold associated with a significant deterioration of insulin sensitivity in postmenopausal women.

    abstract::The aim of this study was to establish a cut-off value of percentage of fat mass (%FM) at which insulin sensitivity (IS) is significantly altered in sedentary postmenopausal women. Our results suggest that maintaining a %FM below 41% would minimize the deterioration of IS and its associated risks. ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Bobeuf F,Aubertin-Leheudre M,Lord C,Labonté M,Khalil A,Dionne IJ

    更新日期:2010-04-01 00:00:00

  • Prevalence of sexual disorders in a selection-free diabetic population (JEVIN).

    abstract::There is an extensive literature on sexual disorders among diabetic patients, but a shortage of studies on their prevalence in selection-free populations. In the present trial (JEVIN), 90% of all insulin-treated diabetic patients (IDDM/NIDDM, n = 127/117) aged 16-60 years and living in the city of Jena (100247 inhabit...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Schiel R,Müller UA

    更新日期:1999-05-01 00:00:00

  • Out-patient management does not impair outcome of pregnancy in women with type 1 diabetes.

    abstract::In recent years, out-patient protocols have mainly displaced historical obstetric management of diabetic pregnancy. The impact of the change from centralized in-patient to decentralized out-patient treatment on glycaemic control and its effects on the outcome of newborns in diabetic pregnancies was therefore studied u...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Vääräsmäki M,Hartikainen AL,Anttila M,Pirttiaho H

    更新日期:2000-02-01 00:00:00

  • Association of Chlamydia pneumoniae infection with diabetic nephropathy.

    abstract::We evaluated the association of Chlamydia pneumoniae (CP) infection with progression of diabetic nephropathy. Type 2 diabetic patients (60) were divided into two groups, those with incipient nephropathy and those with advanced nephropathy, based on the severity of diffuse glomerular lesions using Gellman's criteria. T...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Kanauchi M,Kawano T,Dohi K

    更新日期:2000-01-01 00:00:00

  • Age of diabetes diagnosis and diabetes duration associate with glycated haemoglobin.

    abstract::An earlier age of diagnosis (r=-0.28, p<0.0001) and longer duration of type 2 diabetes (r=0.26, p<0.0001) were each found to correlate with higher HbA1c level, on analysis of a diabetes centre database in people under regular shared care. When combined, these biological variables strongly associate with the current Hb...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Hsieh A,Ong PX,Molyneaux L,McGill MJ,Constantino M,Wu T,Wong J,Yue DK,Twigg SM

    更新日期:2014-04-01 00:00:00

  • Effect of rosuvastatin on capillary filtration of albumin and blood pressure in rats with streptozotocin-induced diabetes.

    abstract::An increase in capillary filtration of albumin (CFA) is well demonstrated in diabetes. Statins may exert a protective effect against endothelial dysfunction. The aim of this study was to test whether rosuvastatin may prevent the increase in peripheral CFA in diabetic rats and the role of blood pressure lowering. Rats ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Tarhzaoui K,Valensi P,Boulakia FC,Lestrade R,Albertini JP,Behar A

    更新日期:2008-06-01 00:00:00

  • Prepregnancy care in women with type 1 diabetes improves HbA1c and glucose variability without worsening hypoglycaemia time and awareness: Glycaemic variability during prepregnancy care.

    abstract:AIMS:To evaluate the impact of a prepregnancy care (PPC) programme, beyond HbA1c, on hypoglycaemia awareness and glycaemic variability (GV). METHODS:Prospective pilot study. We selected women with Type 1 diabetes who initiated a PPC programme with normal hypoglycaemia awareness (n = 24). Hypoglycaemia awareness, hypog...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Perea V,Giménez M,Amor AJ,Bellart J,Conget I,Vinagre I

    更新日期:2019-08-01 00:00:00

  • Global perspectives on the provision of diabetic retinopathy screening and treatment: Survey of health care professionals in 41 countries.

    abstract:AIM:To assess the level of awareness and provision of screening and treatment for Diabetic Eye Disease (DED) comprising Diabetic Retinopathy (DR) and Diabetic Macular Edema (DME) among health care professionals. METHODS:The study was conducted in two phases. The first phase consisted of a qualitative study, based on s...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,多中心研究


    authors: Cavan D,Makaroff LE,da Rocha Fernandes J,Karuranga S,Sylvanowicz M,Conlon J,Chaney D,Malhi A,Barratt J

    更新日期:2018-09-01 00:00:00

  • Impact of mitochondrial ROS production on diabetic vascular complications.

    abstract::Vascular complications are the leading cause of morbidity and mortality in patients with diabetes. Four main molecular mechanisms have been implicated in glucose-mediated vascular disease. There are: glucose-induced activation of protein kinase C (PKC) isoforms; increased formation of glucose-derived advanced glycatio...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Nishikawa T,Kukidome D,Sonoda K,Fujisawa K,Matsuhisa T,Motoshima H,Matsumura T,Araki E

    更新日期:2007-09-01 00:00:00

  • Influence of cardiovascular autonomic neuropathy on atherogenesis and heart function in patients with type 1 diabetes.

    abstract:AIM:Cardiovascular autonomic neuropathy (CAN) increases mortality of patients with type 1 diabetes (Type 1 DM). We set out to find out whether the presence of CAN in asymptomatic, normotensive Type 1 DM affects endothelial function (marker of atherogenesis) and left ventricle function (marker of cardiomyopathy). METHO...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Lacigova S,Bartunek L,Cechurova D,Visek J,Gruberova J,Krcma M,Jankovec Z,Rusavy Z,Zourek M

    更新日期:2009-01-01 00:00:00

  • Obesity with and without metabolic syndrome: do vitamin D and thyroid autoimmunity have a role?

    abstract:AIMS:To investigate serum levels of thyroid stimulating hormone (TSH), anti-thyroid peroxidase antibody (TPO), and 25(OH)D in the presence or absence of metabolic syndrome in an obese population. METHODS:Data from a prospectively generated "Obesity Polyclinic" database that includes socio-demographic characteristics, ...

    journal_title:Diabetes research and clinical practice

    pub_type: 临床试验,杂志文章


    authors: Agbaht K,Mercan Y,Kutlu S,Alpdemir MF,Sezgin T

    更新日期:2014-10-01 00:00:00

  • The influence of carbohydrate consumption on glycemic control in pregnant women with type 1 diabetes.

    abstract:AIMS:To study the influence of the quantity and the quality of carbohydrate consumption on glycemic control in early pregnancy among women with type 1 diabetes. METHODS:A retrospective study of 107 women with type 1 diabetes who completed 1-3days of diet recording before first antenatal visit, as a part of routine car...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章


    authors: Ásbjörnsdóttir B,Akueson CE,Ronneby H,Rytter A,Andersen JR,Damm P,Mathiesen ER

    更新日期:2017-05-01 00:00:00

  • 2-year effects of pioglitazone add-on to sulfonylurea or metformin on oral glucose tolerance in patients with type 2 diabetes.

    abstract:AIM:We report the effectiveness of the thiazolidinedione, pioglitazone, as add-on medication to metformin or sulfonylurea in reducing post-load serum glucose levels, as assessed by 3-h oral glucose tolerance testing (OGTT). METHODS:Adult patients with Type 2 diabetes took part in one of two large-scale, 2-year clinica...

    journal_title:Diabetes research and clinical practice

    pub_type: 临床试验,杂志文章


    authors: Seufert J,Urquhart R

    更新日期:2008-03-01 00:00:00