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An immunopotentiator of beta-1,6;1,3 D-glucan prevents diabetes and insulitis in BB rats.

Abstract：

:The preventive effect of an immunopotentiator, beta-1,6;1,3 D-glucan, on the development of diabetes and insulitis was studied in BB rats. The intravenous administration of 1 mg kg-1 week-1 of beta-1,6;1,3 D-glucan from the age of 4 weeks decreased the cumulative incidence of diabetes from 43.3% (13/30) to 6.7% (2/30) (P less than 0.005) and also the incidence of insulitis from 82.4% (14/17) to 26.3% (5/19) at the age of 20 weeks (P less than 0.002). Eight of nine rats were free from diabetes for 5 weeks after stopping beta-1,6;1,3 D-glucan at the age of 20 weeks. The total numbers of leukocytes in the peripheral blood and spleen of the rats were increased by beta-1,6;1,3 D-glucan treatment (P less than 0.05), whereas their T lymphocytes subsets were not changed. These data indicate that immunopotentiators could modulate the autoimmune mechanisms directed to pancreatic islets and inhibit the development of diabetes in BB rats.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Kida K,Inoue T,Kaino Y,Goto Y,Ikeuchi M,Ito T,Matsuda H,Elliott RB

doi

10.1016/0168-8227(92)90152-h

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

75-9

issue

2

eissn

0168-8227

issn

1872-8227

pii

0168-8227(92)90152-H

journal_volume

17

pub_type

杂志文章

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