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Sex differences in insulin sensitivity and insulin response with increasing age in black South African men and women.

Abstract：

AIMS:Black Africans are disproportionally affected by type 2 diabetes, but the pathophysiology is poorly understood. The study aimed to examine the effect of sex and age on insulin sensitivity and insulin response in black South African adults. METHODS:This cross-sectional study included a random sample of 179 men and 260 women aged 25-74years with normal glucose tolerance from 5 peri-urban townships in Cape Town, SA. Insulin sensitivity (insulin sensitivity index, ISI0,120) and response (insulinogenic index, IGI), and the disposition index (DI, ISI0,120×IGI), derived from an oral glucose tolerance test, were measured. RESULTS:Although men were older (median [interquartile range]: 39 [30-48] vs. 35 [29-44], P=0.021) and had significantly lower BMI than women (22.6 [20.0-25.3] vs. 31.0 [25.9-35.7] kg/m2, P=0.001), DI was not different (P=0.740), but ISI0,120 was higher (P=0.007) and IGI was lower (P=0.074) in men than women, adjusting for age and BMI. With increasing age, DI (β (95%CI): -24.4 (-36.3 to -12.5), P<0.001) and IGI (β (95%CI): -4.9 (-7.5 to -2.2), P<0.001) decreased similarly in both sexes, but ISI0,120 did not change (β (95%CI): 0.005 (-0.20 to 0.03), P=0.675). CONCLUSION:Black South African women with normal glucose tolerance have lower insulin sensitivity than their male counterparts, but increase their insulin response to maintain normoglycemia. With increasing age, insulin sensitivity remains unchanged, but the insulin response decreases at a similar rate in men and women.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Goedecke JH,George C,Veras K,Peer N,Lombard C,Victor H,Steyn K,Levitt NS

doi

10.1016/j.diabres.2016.11.005

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

207-214

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(16)30322-9

journal_volume

122

pub_type

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