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Measurement of cytosolic free calcium concentration in relation to insulin release in normal rat pancreatic islets.

Abstract：

:The effects of glucose (16.7 mM), potassium (50 mM), forskolin (20 microM), dibutyryl cyclic AMP (1 mM) and arachidonic acid (82 microM) upon insulin release and cytosolic free calcium concentrations ([Ca2+]i) were investigated in normal rat pancreatic islets. Potassium, forskolin and dibutyryl cyclic AMP significantly raised [Ca2+]i, but elicited only minimal insulin release. In the absence of extracellular Ca2+, glucose evoked insulin release, but failed to augment [Ca2+]i. Arachidonic acid increased [Ca2+]i both in Ca-depleted and -repleted medium, but promoted insulin release only in Ca2+-repleted environment. These new observations clearly demonstrate by direct measurements that although [Ca2+]i is an important factor in exocytotic insulin release, its effect is subject to amplification or antagonism.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Draznin B,Metz SA,Sussman KE,Leitner JW

doi

10.1016/s0168-8227(87)80053-0

subject

Has Abstract

pub_date

1987-09-01 00:00:00

pages

291-5

issue

5

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(87)80053-0

journal_volume

3

pub_type

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