Abstract：
AIM:To determine the possible factors predicting the insulin requirement in pregnancies complicated by gestational diabetes mellitus (GDM). METHOD:A total of 294 patients with GDM diagnosed by the 100-g/3-h oral glucose tolerance test (OGTT) were studied. The following factors were analyzed: maternal age, nulliparity, family history of diabetes, prepregnancy BMI, prior GDM, prior fetal macrosomia, multiple pregnancy, polyhydramnios, gestational age at diagnosis of GDM, smoking, hypertension, number of abnormal 100-g/3-h OGTT values, and glycated hemoglobin (HbA1c). The association between each factor and the need for insulin therapy was then analyzed individually. The performance of these factors to predict the probability of insulin therapy was estimated using a logistic regression model. RESULTS:Univariate analysis showed a positive correlation between insulin therapy and prepregnancy BMI, family history of diabetes, hypertension, prior GDM, prior fetal macrosomia, number of abnormal 100-g/3-h OGTT values, and HbA1c (P<0.05). Prepregnancy BMI, family history of diabetes, number of abnormal 100-g/3-h OGTT values and HbA1c were statistically significant variables in the logistic regression model. CONCLUSIONS:The probability of insulin therapy can be estimated in pregnant women with GDM based on prepregnancy BMI, family history of diabetes, number of abnormal 100-g/3-h OGTT values, and HbA1c concentration.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Sapienza AD,Francisco RP,Trindade TC,Zugaib Mdoi
10.1016/j.diabres.2009.12.023subject
Has Abstractpub_date
2010-04-01 00:00:00pages
81-6issue
1eissn
0168-8227issn
1872-8227pii
S0168-8227(09)00548-8journal_volume
88pub_type
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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pub_type： 杂志文章,评审
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：2018-05-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
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更新日期：2011-01-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：2014-11-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(03)00013-5
更新日期：2003-05-01 00:00:00
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journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
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更新日期：1987-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.diabres.2007.10.014
更新日期：2008-03-01 00:00:00
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更新日期：2007-02-01 00:00:00
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更新日期：2007-04-01 00:00:00
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更新日期：2018-04-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2006-04-01 00:00:00
abstract：:A transient rise in hepatic glucose production (HGP) after an oral glucosa load has been reported in some insulin-resistant states such as in obese fa/fa Zucker rats. The aim of this study was to determine whether this rise in HGP also occurs in subjects with established non-insulin-dependent diabetes mellitus (NIDDM)...
journal_title：Diabetes research and clinical practice
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更新日期：1995-05-01 00:00:00
abstract：:Amelioration of albuminuria may be related to specific constellations of risk factors including race and dyslipidaemia. Circulating cholesterol could mitigate the beneficial effect of antihypertensive therapy. We assessed whether cholesterol affected the remission of urinary albumin in patients with type 2 diabetes of...
journal_title：Diabetes research and clinical practice
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更新日期：2008-01-01 00:00:00
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更新日期：2018-07-01 00:00:00
abstract：:Insulin resistance is a hallmark of type 2 diabetes and obesity while the mechanism remains unclear. Current therapy to treat type 2 diabetes is metformin, the 5'-monophosphate-activated protein kinase (AMPK) activator, owing to the ability to augment peripheral glucose uptake. However, metformin also displays limitat...
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pub_type： 杂志文章,评审
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更新日期：2019-10-01 00:00:00
abstract：AIMS:To evaluate whether progressively higher fasting plasma glucose (FPG) is associated to thickening of the interventricular septum (IVS) among non-diabetic subjects with obesity. METHODOLOGY:We studied 227 consecutive non diabetic patients (155 women and 72 men, age range 18-72 years) with overweight or obesity (BM...
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pub_type： 杂志文章
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更新日期：2020-11-01 00:00:00
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journal_title：Diabetes research and clinical practice
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abstract：:Comprehension of the effect of diabetes mellitus on auditory function has been hindered by the fact that previous studies have evaluated hearing function in heterogeneous groups of patients with diabetes mellitus, thus giving conflicting results. We have performed audiometric studies in 46 consecutive patients. 13 wit...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(91)90136-2
更新日期：1991-01-01 00:00:00
