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Effect of fast-food Mediterranean-type diet on type 2 diabetics and healthy human subjects' platelet aggregation.

Abstract：

OBJECTIVE:The aim of our work was to carry out a randomized clinical trial with a fast-food Mediterranean type diet rich in platelet activating factor (PAF) antagonist to investigate the effect on type 2 diabetics and healthy human subject's platelet aggregation. RESEARCH DESIGN AND METHODS:We extracted lipids from fast-food Mediterranean type foodstuffs, and tested them in vitro for their ability to inhibit or antagonize PAF towards washed rabbit platelets. We chose the foodstuffs that exerted the most potent in vitro anti-PAF activity and fed 22 healthy (group A) and 23 type 2 diabetics (group B) subjects on a diet containing the chosen foodstuffs. The 22 type 2 diabetics (group C) subjects were kept on their regular diet that was being followed before entering the study. Before and after a 4-week diet, all enrolled subjects underwent the following examinations; measurement of total cholesterol, low density lipoprotein (LDL-cholesterol), high density lipoprotein (HDL-cholesterol), triglycerides, glucose, HbA(1c), body mass index (BMI), and platelet aggregation in response to PAF, adenosine 5' diphosphate (ADP) and arachidonic acid (AA). RESULTS:The chosen diet significantly increased the EC(50) values of PAF and ADP to groups A and B (p<0.05). No statistical difference was observed on the EC(50) value of group C. No statistical differences were detected among Cholesterol, LDL-cholesterol, triglycerides, glucose, HBA(1c), BMI, and EC(50) for AA values, for any of the three groups. CONCLUSIONS:Consumption of a fast-food Mediterranean type diet rich in PAF antagonist improved platelet response of type 2 diabetics and healthy human subjects against thrombotic, inflammatory and proatherogenic factors.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Karantonis HC,Fragopoulou E,Antonopoulou S,Rementzis J,Phenekos C,Demopoulos CA

doi

10.1016/j.diabres.2005.09.003

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

33-41

issue

1

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(05)00359-1

journal_volume

72

pub_type

杂志文章,随机对照试验

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