Abstract：
:Amelioration of albuminuria may be related to specific constellations of risk factors including race and dyslipidaemia. Circulating cholesterol could mitigate the beneficial effect of antihypertensive therapy. We assessed whether cholesterol affected the remission of urinary albumin in patients with type 2 diabetes of white, Caucasian and non-white origin. We studied 100 patients (African and Asian: n=57 and Caucasian: n=43) with type 2 diabetes and newly diagnosed microalbuminuria who received intensified and structured care for a median (IQ range) of 41 (32-48) months. Microalbuminuria remitted in 20% and progressed in 12% of patients. In those with uncontrolled systolic hypertension (>140 mmHg) systolic blood pressure fell by a mean (95% CI) of -9.4 (-3.8 to -15.11)mmHg; p=0.002. The change in urinary albumin excretion with time varied inversely with baseline systolic blood pressure (r=-0.25; p=0.04). At 3 years follow-up the decrement in blood pressure was significant for those patients in the regression group (-19.6[16.8]mmHg; p=0.005). In patients of African origin, systolic blood pressure was higher than in the other groups and correlated with cholesterol concentrations (r=0.44; p=0.04). Baseline systolic blood pressure and total cholesterol (odds ratio [95%CI]) were independent determinants of remission and progression of microalbuminuria (1.04[1.006-1.064]; p=0.02 and 1.75[1.03-2.95]; p=0.04). Patients with higher total cholesterol and baseline urinary albumin excretion were less likely to go into remission. Blood pressure correlated with cholesterol concentrations in patients of African origin. Specific cholesterol lowering strategies may benefit certain patients groups at high risk of renal disease.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Earle KA,Harry D,Zitouni Kdoi
10.1016/j.diabres.2007.07.014subject
Has Abstractpub_date
2008-01-01 00:00:00pages
68-73issue
1eissn
0168-8227issn
1872-8227pii
S0168-8227(07)00347-6journal_volume
79pub_type
杂志文章abstract：:Thirty diabetics who had been receiving ordinary insulin were switched to S-lente insulin, a new mixture of four parts semilente and six parts ultralente insulin. Eight times a day, we measured the glucose, insulin, and C-peptide (CPR) in their blood. Those with more than 250 mg/dl postprandial glucose were designated...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(90)90019-p
更新日期：1990-01-01 00:00:00
abstract：AIMS:To directly compare the effectiveness and safety between two distinct sodium-glucose co-transporter 2 (SGLT2) inhibitors, empagliflozin and dapagliflozin, as part of a quadruple oral antidiabetic agents (OADs) in patients with inadequately controlled type 2 diabetes (T2D). METHODS:This study was an open-labeled, ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2019.04.008
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVE:Studies of diabetes in migrant populations have shown a higher prevalence compared to their respective countries of origin and to people natively born in the host country, but there is little population-based data on diabetes incidence and mortality in migrant populations. The aim of the current study was (1)...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2016.09.020
更新日期：2016-12-01 00:00:00
abstract：:In Madras city (India) 10,513 school students between 3 and 20 yr of age were investigated for glycosuria and its causes. While no previously known cases of diabetes mellitus of any type were encountered, four students (0.038%) in the survey population were found to have glycosuria. One (0.009%) had renal glycosuria, ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(91)90043-d
更新日期：1991-08-01 00:00:00
abstract：AIM:To identify characteristics of neuropsychological function among elderly individuals with Type 2 diabetes mellitus with mild cognitive impairment (T2DM-MCI) and evaluate domain-specific effects of T2DM on cognition. METHODS:This was a cross-sectional study conducted in Tianjin, China. MCI subjects (n=246) and cont...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2015.05.019
更新日期：2015-08-01 00:00:00
abstract：:This study aims to investigate whether renal and cardiovascular phenotypes in Italian patients with type 2 diabetes (T2D) could be influenced by a number of disease risk SNPs recently found in genome-wide association studies (GWAS). In 1591 Italian subjects with T2D: (1) 47 SNPs associated to kidney function and/or ch...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2018.08.013
更新日期：2018-10-01 00:00:00
abstract：AIMS:Centrally administered insulin improves cognitive functions in patients with Alzheimer's disease; however, it remains unknown whether long-acting insulin analogs exert more pronounced effects than insulin. In the present study, we directly compared the effects of insulin and its analogs on neural functions in vitr...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2017.03.032
更新日期：2017-07-01 00:00:00
abstract：:This study was done to see whether 27-base pair repeats polymorphism in intron 4 of ecNOS gene is associated with carotid atherosclerosis in type 2 diabetic patients. The polymorphism was identified by polymerase chain reaction (PCR). Ultrasound parameters of carotid atherosclerosis were analyzed in relation to the ge...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2005.11.002
更新日期：2006-06-01 00:00:00
abstract：AIMS:Body-weight fluctuation is associated with an increased risk of all-cause mortality. Yet no studies investigate its association with risk of diabetes in adults aged ≥ 60 years. This study aimed to address this issue. METHODS:A total of 1,565 participants free of diabetes at baseline in the CHARLS were followed fo...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108419
更新日期：2020-11-01 00:00:00
abstract：:Mutations of mitochondrial DNA have been found in cardiomyopathic and diabetic patients as well as mitochondrial myopathic patients. Mitochondrial DNA mutations are maternally transmitted. It has also been reported that these mutations can be acquired under the influence of free radicals. This article is a mini-review...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/0168-8227(96)01239-9
更新日期：1996-07-01 00:00:00
abstract：:Serum paraoxonase (PON) is a high-density lipoprotein-bound enzyme that can prevent oxidation of low-density lipoprotein by hydrolyzing lipid peroxides and thus exert an anti-atherogenic effect. Recent studies have suggested that glutamine(Q isoform)/arginine(R isoform) polymorphism at position 192 of PON(1) gene is a...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(03)00058-5
更新日期：2003-07-01 00:00:00
abstract：:This study examined the prevalence of retinopathy in 2131 patients with type 2 diabetes attending a Beijing hospital for the first time. The median age of patients was 58 years (IQR 50-65). The overall prevalence of retinopathy was 27.3% (95% CI: 25.4-29.2) and for proliferative retinopathy 7.8% (95% CI: 6.7-8.9). Whe...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(01)00349-7
更新日期：2002-05-01 00:00:00
abstract：:A retrospective analysis of blood glucose control was performed in 17 type 1 diabetic patients who regularly monitored their blood glucose concentration by visual strips over a period of 3-83 months. Analysis was performed by a patient management software loaded on a personal computer. In this cohort of patients the a...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(92)90117-a
更新日期：1992-06-01 00:00:00
abstract：AIMS:Studies have shown that diabetes mellitus disproportionately afflicts persons of low socioeconomic status and that the burden of disease is greatest among the disadvantaged. However, our understanding of educational differences in the control of diabetes and its impact on survival is limited. This study investigat...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2014.12.013
更新日期：2015-03-01 00:00:00
abstract：AIMS:Endothelial progenitor cells (EPCs) play a critical role in neovascularization, which enhances proliferation under all-trans retinoic acid (ATRA) treatment. However, the effects of ATRA on the skin flap survival in diabetic flap ischemia remains unknown. METHODS:Ischemic random skin flaps were made in 40 diabetic...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2018.06.019
更新日期：2018-08-01 00:00:00
abstract：:Patients with diabetes mellitus have a higher rate of mortality than the general population. This higher mortality may be attributed mainly to cardiovascular disease. A high prevalence of dyslipidemia in diabetics can be one of the reasons for this. The most commonly recognized lipid abnormality in non-insulin-depende...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/0168-8227(96)01263-6
更新日期：1996-06-01 00:00:00
abstract：:Four patients who exhibited the greatest decline in the estimated glomerular filtration rate [12.3-23.5 ml/min/1.73 m(2)/year] among 320 patients with type 2 diabetes and were followed for a median of 6.8 years had several clinical features in common, including marked albuminuria, microhematuria, retinopathy and poor ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2013.01.031
更新日期：2013-05-01 00:00:00
abstract：AIMS:Evidence suggests that screening for gestational diabetes (GDM) occurs too late in pregnancy, when changes in glucose metabolism and fetal growth rates can already be detected. In August 2016 NHS Lothian began screening women with risk factors for GDM during early pregnancy (11-13 weeks). We hypothesised that an e...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2018.09.013
更新日期：2018-10-01 00:00:00
abstract：:There is evidence to suggest that hyperglycemia is required for the development of the microvascular complications of diabetes. However, the precise mechanism by which hyperglycemia might cause diabetic complications is not completely clear. One possibility is the increased activity of the polyol pathway. Capillary ba...
journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0168-8227(91)90094-t
更新日期：1991-02-01 00:00:00
abstract：:Dietary cod-liver oil containing eicosapentaenoic acid is effective on microvascular albumin leakage in diabetic patients with albuminuria. We determined the long-term effects of oral pure eicosapentaenoic acid ethyl (EPA-E: 900 mg/day) administration on diabetic nephropathy in non-insulin dependent diabetic (NIDDM) p...
journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0168-8227(95)01056-j
更新日期：1995-04-01 00:00:00
abstract：BACKGROUND:While the mechanisms leading to β-cell destruction and clinical onset of T1D are still unclear, the composition of the immune profile is probably important for the outcome of immune activity. The aim of this study was to investigate the composition and possible changes of the immunological profile, spontaneo...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2013.01.014
更新日期：2013-04-01 00:00:00
abstract：:Significant changes in gastrointestinal function, decreased gastric secretion and motility in particular, are often observed in patients with chronic diabetes. The mechanisms leading to those remain unclear. In these studies we evaluated the gastric acid secretory response to insulin and pentagastrin in normal Wistar ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(97)00087-9
更新日期：1997-10-01 00:00:00
abstract：AIMS:To evaluate the utilisation of technologies and associated glycaemia among adults with type 1 diabetes. METHODS:De-identified data from adults with type 1 diabetes (≥18 years old) in the Australian National Diabetes Audit (ANDA)-2019 were analysed. Proportions using insulin pumps or injections with continuous glu...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108609
更新日期：2020-12-10 00:00:00
abstract：:Recent clinical and experimental studies have suggested that diabetic patients may develop myocardial dysfunction in the absence of coronary heart disease and hypertension. In this study, the correlation between histopathological changes and myocardial dysfunction was studied in experimental diabetic rat hearts. Male ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(05)80031-2
更新日期：1991-03-01 00:00:00
abstract：OBJECTIVE:Sodium-glucose co-transporter-2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) are now considered as key players in the treatment of type 2 diabetes mellitus (T2DM). The purpose of this meta-analysis was to provide precise effect estimates regarding the safety and efficacy of th...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,meta分析
doi：10.1016/j.diabres.2019.107927
更新日期：2019-12-01 00:00:00
abstract：AIMS:To evaluate whether progressively higher fasting plasma glucose (FPG) is associated to thickening of the interventricular septum (IVS) among non-diabetic subjects with obesity. METHODOLOGY:We studied 227 consecutive non diabetic patients (155 women and 72 men, age range 18-72 years) with overweight or obesity (BM...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108436
更新日期：2020-11-01 00:00:00
abstract：:Social determinants of health (SDH) impact clinical outcomes and are often poorly described in research trials. Using a validated tool, SDH dimensions were compared between adolescents enrolled and not enrolled into a large diabetes study. We observed that our study cohort reflected a SDH profile mirroring the eligibl...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2016.01.031
更新日期：2016-03-01 00:00:00
abstract：:One of the major public health challenges of the 21st century is type 2 diabetes. WHO estimates that by 2025 as many as 200-300 million people worldwide will have developed the disease. A distressing increase in children is perhaps the most alarming sign of something going wrong. Roughly half of the risk of type 2 dia...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/j.diabres.2006.09.020
更新日期：2007-06-01 00:00:00
abstract：:Abdominal obesity has emerged as a strong and independent predictor for non-insulin dependent diabetes mellitus (NIDDM). Adiposity located centrally in the abdominal region, and particularly visceral as opposed to subcutaneous fat, is also distinctly associated with hyperlipidemia, compared with generalized distributi...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/s0168-8227(96)80035-0
更新日期：1996-02-01 00:00:00
abstract：:Insulin resistance is known as an important risk factor for coronary artery disease (CAD). However, CAD-related mortality in Japanese type 2 diabetics is lower than in Caucasians. To investigate whether insulin resistance is related to CAD in Japanese type 2 diabetics, we measured insulin sensitivity and several coron...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(00)00228-x
更新日期：2001-03-01 00:00:00
