当前位置： SCI文献检索 > DIABETES RESEARCH AND CLINICAL PRACTICE期刊下所有文献 > Impaired insulin but normal pentagastrin effect on gastric acid secretion in diabetic rats: a role for nitric oxide.

Impaired insulin but normal pentagastrin effect on gastric acid secretion in diabetic rats: a role for nitric oxide.

Abstract：

:Significant changes in gastrointestinal function, decreased gastric secretion and motility in particular, are often observed in patients with chronic diabetes. The mechanisms leading to those remain unclear. In these studies we evaluated the gastric acid secretory response to insulin and pentagastrin in normal Wistar and streptozotocin diabetic rats. We also sought to determine the role of nitric oxide (NO) in this process. The animals were anesthetized with sodium pentobarbital. Warm saline was perfused through a polyethylene tube placed in the oesophagus and collected from the duodenum at 10 min intervals. Following a 50 min equilibration period, a bolus intra-jugular infusion of insulin (4.0 U/kg), 2-deoxyglucose (200 mg/kg) or pentagastrin 4.0 (ug/kg) was started and samples of the gastrointestinal perfusate were collected for an additional 80 min. Insulin-stimulated acid secretion peaked 60 min after bolus infusion in normal animals; a response that was significantly decreased in the diabetic rats. Similarly, 2-deoxyglucose-induced glucopenia increased gastric acid secretion to a lower extent in diabetic versus normal rats. The stimulatory response to pentagastrin was prompt and essentially equal in normal and diabetic animals. However, when hypoglycemia was prevented by glucose infusion, insulin did not stimulate gastric acid secretion in normal rats. Further, glucose infusion in these animals actually enhanced the secretory response to pentagastrin. Nitro-L-arginine methyl ester (L-NAME 20 mg/kg i.v.), an inhibitor of NO synthetase, also prevented the secretory response to insulin but not to pentagastrin. Preinfusion of arginine (100 mg/kg i.v.) in diabetic rats restored the gastric secretory response to insulin toward that of normal animals. We conclude that the gastric acid secretory response to insulin, but not to pentagastrin, is decreased in diabetic animals, that this response may operate through a NO mediated mechanism possibly set in motion by central nervous system glucopenia and that this NO-mediated mechanism is attenuated in diabetes.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Baydoun R,Dunbar JC

doi

10.1016/s0168-8227(97)00087-9

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

1-8

issue

1

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(97)00087-9

journal_volume

38

pub_type

杂志文章

相关文献

DIABETES RESEARCH AND CLINICAL PRACTICE文献大全
  • Acarbose in the treatment of elderly patients with type 2 diabetes.

    abstract：AIMS:To study the effect of acarbose, an alpha-glucosidase inhibitor, on glycemic control in elderly patients with type 2 diabetes. METHODS:Elderly patients with type 2 diabetes treated with diet alone were randomly treated in a double-blind fashion with placebo (n=99) or acarbose (n=93) for 12 months. RESULTS:After ...

    journal_title：Diabetes research and clinical practice

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0168-8227(02)00176-6

    authors： Josse RG,Chiasson JL,Ryan EA,Lau DC,Ross SA,Yale JF,Leiter LA,Maheux P,Tessier D,Wolever TM,Gerstein H,Rodger NW,Dornan JM,Murphy LJ,Rabasa-Lhoret R,Meneilly GS

    更新日期：2003-01-01 00:00:00

  • Clinical characteristics of Korean type 2 diabetic patients in 2005.

    abstract：:Korean type 2 diabetics differ from Western diabetics in showing non-obese but centrally obese anthropometry and relatively more insulin secretory defects than insulin resistance. We assessed insulin secretion based on fasting serum C-peptide level and insulin resistance using the short insulin tolerance test (Kitt; r...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2007.01.067

    authors： Kim DJ,Song KE,Park JW,Cho HK,Lee KW,Huh KB

    更新日期：2007-09-01 00:00:00

  • Key elements for successful intensive insulin pump therapy in individuals with type 1 diabetes.

    abstract：OBJECTIVE:Clinical trials have demonstrated that in individuals with type 1 diabetes the use of CSII pump resulted in better glucose control. Advantages of pumps therapy include many features such as the bolus calculators (wizard). These features are optional and therefore it is important to determine whether their use...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2011.01.002

    authors： Cukierman-Yaffe T,Konvalina N,Cohen O

    更新日期：2011-04-01 00:00:00

  • Short-term aerobic exercise improves arterial stiffness in type 2 diabetes.

    abstract：OBJECTIVE:To investigate whether: (1) aerobic exercise decreases arterial stiffness and (2) reduction in arterial stiffness is associated with improvement in insulin resistance in type 2 diabetes. METHODS:Common carotid and femoral arterial stiffness was ultrasonographically evaluated using stiffness index beta in 23 ...

    journal_title：Diabetes research and clinical practice

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.diabres.2003.12.005

    authors： Yokoyama H,Emoto M,Fujiwara S,Motoyama K,Morioka T,Koyama H,Shoji T,Inaba M,Nishizawa Y

    更新日期：2004-08-01 00:00:00

  • Evaluation of a real-time blood glucose monitor in children with diabetic ketoacidosis.

    abstract：:Use of a real-time bedside glucose monitor was analyzed during the course of management of diabetic ketoacidosis (DKA) in children. Simultaneous determinations of blood glucose were obtained, using three methods: bedside glucose meter (One Touch II), laboratory glucose analyzer (YSI 2300 STAT), and a real-time bedside...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(99)00033-9

    authors： Coss-Bu JA,Jefferson LS,Stone-McCord S,Ou CN,Watrin C,Sachdeva R,Copeland KC

    更新日期：1999-06-01 00:00:00

  • Relationship between metabolic syndrome components and vascular properties in Japanese type 2 diabetic patients without cardiovascular disease or nephropathy.

    abstract：:To investigate the effect of metabolic syndrome (MS) components on early atherosclerosis markers, i.e., urinary albumin excretion rate (UAE), pulse wave velocity (PWV), and carotid intima-media thickness (IMT), we studied 536 Japanese patients with type 2 diabetes without cardiovascular disease or nephropathy. The MS ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2006.06.015

    authors： Yokoyama H,Kuramitsu M,Kanno S,Tada J,Yokota Y,Kamikawa F

    更新日期：2007-02-01 00:00:00

  • Changes in apoptosis and Bcl-2 expression in human hyperglycemic, term placental trophoblast.

    abstract：:Apoptosis and its associated regulatory mechanisms are physiological events crucial to the maintenance of placental homeostasis; imbalance of these processes, however, such as occurs under various pathological conditions, may compromise placenta function and, consequently, pregnancy success. Increased apoptosis occurs...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2005.12.014

    authors： Sgarbosa F,Barbisan LF,Brasil MA,Costa E,Calderon IM,Gonçalves CR,Bevilacqua E,Rudge MV

    更新日期：2006-08-01 00:00:00

  • Retrospective analysis of hemodialyzed diabetic patients in Japan.

    abstract：:We retrospectively analyzed the courses of 37 non-insulin dependent diabetics (hemodialyzed:HD group) with end-stage renal disease (ESRD), to identify factors predisposing to renal failure. The factors analyzed were: diabetic (non-proliferative and proliferative) retinopathy, family histories of diabetes and hypertens...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(95)01130-7

    authors： Takei I,Yamauchi A,Nakamoto S,Suzuki H,Saruta T

    更新日期：1995-09-01 00:00:00

  • Prepregnancy care in women with type 1 diabetes improves HbA1c and glucose variability without worsening hypoglycaemia time and awareness: Glycaemic variability during prepregnancy care.

    abstract：AIMS:To evaluate the impact of a prepregnancy care (PPC) programme, beyond HbA1c, on hypoglycaemia awareness and glycaemic variability (GV). METHODS:Prospective pilot study. We selected women with Type 1 diabetes who initiated a PPC programme with normal hypoglycaemia awareness (n = 24). Hypoglycaemia awareness, hypog...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2019.06.015

    authors： Perea V,Giménez M,Amor AJ,Bellart J,Conget I,Vinagre I

    更新日期：2019-08-01 00:00:00

  • Autoantibodies to glutamic acid decarboxylase (GAD), 64,000-Mr islet cell protein (64K) antibodies and islet cell antibodies (ICA) in insulin-dependent diabetes mellitus with and without autoimmune diseases in Japan.

    abstract：:IDDM is known to be a heterogeneous disease which is frequently complicated with other autoimmune diseases (AID). We previously reported that IDDM patients with AID were characterized by late onset of diabetes, persistent ICA-positivity and increased association with DR9, while those without AID were characterized by ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(94)90233-x

    authors： Akawaza S,Kawasaki E,Yano M,Abiru N,Yamaguchi Y,Nagataki S

    更新日期：1994-10-01 00:00:00

  • The metabolic syndrome in Australia: prevalence using four definitions.

    abstract：OBJECTIVE:To compare the prevalence of the Metabolic Syndrome (MetS) defined by four definitions and to determine which definition best identifies those at high cardiovascular disease (CVD) risk and with insulin resistance. METHODS:AusDiab is a population-based survey of 11,247 Australians. Participants had anthropome...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2007.02.002

    authors： Cameron AJ,Magliano DJ,Zimmet PZ,Welborn T,Shaw JE

    更新日期：2007-09-01 00:00:00

  • Subcutaneous antihistamine injection is effective to control a local allergic reaction to human insulin.

    abstract：:A 31-year-old woman, having a type-1 diabetes and an insulin allergy, was successfully treated with a subcutaneous antihistamine injection to the next continuous subcutaneous insulin infusion site. ...

    journal_title：Diabetes research and clinical practice

    pub_type： 信件

    doi：10.1016/j.diabres.2009.05.013

    authors： Imakado S,Hamada K,Atsumi Y

    更新日期：2009-09-01 00:00:00

  • CCR5Delta32 genotype is associated with outcome in type 2 diabetes mellitus.

    abstract：AIMS:To test whether the genetic variant CCR5Delta32 in the CC-chemokine receptor 5, which is known to lead to CCR5 deficiency, is associated with mortality in type 2 diabetes patients. METHODS:We examined the effect of presence or absence of the CCR5Delta32 on overall and cardiovascular mortality risk in the Zwolle O...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2009.08.013

    authors： Muntinghe FL,Gross S,Bakker SJ,Landman GW,van der Harst P,Bilo HJ,Navis G,Zuurman MW

    更新日期：2009-11-01 00:00:00

  • Nutritional assessment of older adults with diabetes mellitus.

    abstract：AIMS:We aimed to screen the nutritional status of older adults with diabetes mellitus, seeking to outline the needs of this population group considering their socioeconomic status. METHODS:Cross-sectional study of 246 diabetic people aged 65-94 years in Northeastern Brazil. Semi-structured questionnaires were used to ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2019.107819

    authors： Saintrain MVL,Sandrin RLESP,Bezerra CB,Lima AOP,Nobre MA,Braga DRA

    更新日期：2019-09-01 00:00:00

  • Causal and bidirectional linkages over time between depression and diabetes regimen distress in adults with type 2 diabetes.

    abstract：AIMS:Diabetes regimen distress (RD) and depression are related constructs, however the nature of their relationship has not been explored over time, leading to difficulties differentiating between RD and depression and for selection of programs of care. We examined longitudinal associations between RD and depression to...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.diabres.2014.12.017

    authors： Hessler D,Fisher L,Strycker LA,Arean PA,Bowyer V

    更新日期：2015-05-01 00:00:00

  • Hospital admissions, emergency department utilisation and patient activation for self-management among people with diabetes.

    abstract：AIMS:To assess the relationship between patient activation for self-management and admissions to hospital or attendances at emergency departments among people with diabetes, after controlling for other known associations. METHODS:Patients were randomly selected from Australia's National Diabetes Services Scheme and in...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2011.05.031

    authors： Begum N,Donald M,Ozolins IZ,Dower J

    更新日期：2011-08-01 00:00:00

  • Incidence of children with slowly progressive form of type 1 diabetes detected by the urine glucose screening at schools in the Tokyo Metropolitan Area.

    abstract：:We investigated the incidence of the slowly progressive form of type 1 diabetes (SPT1D) detected by the urine glucose-screening tests at schools in the Tokyo Metropolitan Area from 1974 to 2004. During this study period, a total of 9,242,259 school students underwent the screening program. Of them, 54 children, 19 mal...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.diabres.2008.01.029

    authors： Urakami T,Suzuki J,Yoshida A,Saito H,Mugishima H

    更新日期：2008-06-01 00:00:00

  • Hepatic and cardiovascular safety of acarbose among type 2 diabetes patients with end-stage renal disease: A nationwide population-based longitudinal study.

    abstract：AIM:To assess the relationship between acarbose and hepatotoxicity, cardiovascular disease (CVD), and mortality among type 2 diabetes (T2D) patients with end-stage renal disease (ESRD). METHODS:32,531 T2D patients with ESRD were identified from Taiwan's National Health Insurance Research Database in 2000~∼2012 and fol...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108489

    authors： Lin WH,Yang CY,Kuo S,Kuo TH,Roan JN,Li CY,Wang MC,Ou HT

    更新日期：2020-10-06 00:00:00

  • Ethnic difference in inter-East Asian subjects with normal glucose tolerance and impaired glucose regulation: a systematic review and meta-analysis focusing on fasting serum insulin.

    abstract：AIMS:To investigate ethnic difference by focusing on fasting serum insulin (FSI) in inter-East Asian subjects with normal glucose tolerance (NGT) and impaired glucose regulation (IGR). METHODS:Data sources included MEDLINE and EMBASE between 2001 and 2007. We conducted a search for articles containing mean or geometri...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.diabres.2008.09.002

    authors： Takeuchi M,Okamoto K,Takagi T,Ishii H

    更新日期：2008-12-01 00:00:00

  • Relationships of apolipoprotein B(100) with the metabolic syndrome in Type 2 diabetes mellitus.

    abstract：:The current study assessed whether features of the metabolic syndrome are associated with higher apolipoprotein B(100) (apoB(100)) levels in people with Type 2 diabetes (n = 298) not taking lipid-lowering drugs. Body-mass index (BMI), waist:hip ratio (WHR), urinary albumin excretion rate, presence or absence of hypert...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(02)00096-7

    authors： Relimpio F,Losada F,Pumar A,Mangas MA,Morales F,Astorga R

    更新日期：2002-09-01 00:00:00

  • Pre-exercise blood glucose affects glycemic variation of aerobic exercise in patients with type 2 diabetes treated with continuous subcutaneous insulin infusion.

    abstract：AIMS:Considering the insulin sensitivity may increase by exercise particularly in patients with type 2 diabetes (T2D), glycemic variation during exercise needs to be studied when the patients are treated with insulin. This study aimed to explore the influence factors of the efficacy and safety of aerobic exercise in pa...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2018.04.043

    authors： Hu Y,Zhang DF,Dai L,Li Z,Li HQ,Li FF,Liu BL,Sun XJ,Ye L,He K,Ma JH

    更新日期：2018-07-01 00:00:00

  • A novel imaging platform for non-invasive screening of abnormal glucose tolerance.

    abstract：:Optical measurement of skin auto-fluorescence (SAF), most likely emanating from accumulated advanced glycation end-products (AGEs), has been proposed for the noninvasive diagnosis of glucose intolerance in clinical settings. Here, we developed a novel imaging system with transmission geometry for SAF measurement and c...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2016.03.014

    authors： Jeong B,Jung CH,Lee YH,Shin IH,Kim H,Bae SJ,Lee DS,Kang ES,Kang U,Kim JJ,Park JY

    更新日期：2016-06-01 00:00:00

  • A patient with diabetes mellitus, cardiomyopathy, and a mitochondrial gene mutation: confirmation of a gene mutation in cardiac muscle.

    abstract：:A 44-year-old woman with diabetes mellitus, cardiomyopathy, and a mitochondrial gene mutation, was reported. She was diagnosed as having diabetes at 33 years of age and was treated with insulin. However, she stopped treatment 6 months later and had no medical care until she developed diabetic ketoacidosis at 41 years ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(95)01100-r

    authors： Kitaoka H,Kameoka K,Suzuki Y,Sasaki E,Majima M,Takada K,Katagiri H,Oka Y,Ohsawa N

    更新日期：1995-06-01 00:00:00

  • Association between serum soluble TNFα receptors and renal dysfunction in type 2 diabetic patients without proteinuria.

    abstract：AIM:The aim of our study was to investigate whether serum levels of soluble tumor necrosis factor α receptor (sTNFR) 1 and 2 are markers for renal dysfunction in type 2 diabetic patients without overt proteinuria. METHODS:Japanese type 2 diabetic patients without overt proteinuria (n = 168) enrolled in the prospective...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2011.01.008

    authors： Miyazawa I,Araki S,Obata T,Yoshizaki T,Morino K,Kadota A,Ugi S,Kawai H,Uzu T,Nishio Y,Koya D,Haneda M,Kashiwagi A,Maegawa H

    更新日期：2011-05-01 00:00:00

  • Insulin resistance and coronary risk factors in Japanese type 2 diabetic patients with definite coronary artery disease.

    abstract：:Insulin resistance is known as an important risk factor for coronary artery disease (CAD). However, CAD-related mortality in Japanese type 2 diabetics is lower than in Caucasians. To investigate whether insulin resistance is related to CAD in Japanese type 2 diabetics, we measured insulin sensitivity and several coron...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(00)00228-x

    authors： Matsumoto K,Kizaki Y,Fukae S,Tomihira M,Sera Y,Ueki Y,Tominaga T,Miyake S

    更新日期：2001-03-01 00:00:00

  • Association of automated carotid IMT measurement and HbA1c in Japanese patients with coronary artery disease.

    abstract：AIMS:The purpose of this study was to evaluate whether carotid IMT (cIMT) identified using automated software is associated with HbA1c in Japanese patients with coronary artery disease. METHODS:370 consecutive patients (males 218; median age 69 years ± 11) who underwent carotid-US and first coronary angiography were p...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2013.03.032

    authors： Saba L,Ikeda N,Deidda M,Araki T,Molinari F,Meiburger KM,Acharya UR,Nagashima Y,Mercuro G,Nakano M,Nicolaides A,Suri JS,Fellow AIMBE.

    更新日期：2013-06-01 00:00:00

  • Comparison of liraglutide plus basal insulin and basal-bolus insulin therapy (BBIT) for glycemic control, body weight stability, and treatment satisfaction in patients treated using BBIT for type 2 diabetes without severe insulin deficiency: A randomized

    abstract：AIMS:We examined whether 0.9 mg/day liraglutide plus basal insulin (Lira-basal) is superior to basal-bolus insulin therapy (BBIT) for type 2 diabetes (T2DM) without severe insulin deficiency as determined by glucagon stimulation. METHODS:Fifty patients receiving BBIT were enrolled in this 24-week, prospective, randomi...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.diabres.2018.03.032

    authors： Yamamoto S,Hayashi T,Ohara M,Goto S,Sato J,Nagaike H,Fukase A,Sato N,Hiromura M,Tomoyasu M,Nakanishi N,Lee S,Osamura A,Yamamoto T,Fukui T,Hirano T

    更新日期：2018-06-01 00:00:00

  • Glycosuria and diabetes mellitus in children and adolescents in south India.

    abstract：:In Madras city (India) 10,513 school students between 3 and 20 yr of age were investigated for glycosuria and its causes. While no previously known cases of diabetes mellitus of any type were encountered, four students (0.038%) in the survey population were found to have glycosuria. One (0.009%) had renal glycosuria, ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(91)90043-d

    authors： Bai PV,Krishnaswami CV,Chellamariappan M,Kumar GV,Subramaniam JR

    更新日期：1991-08-01 00:00:00

  • Clinical features associated with a rapid decline in renal function among Japanese patients with type 2 diabetes mellitus: microscopic hematuria coexisting with diabetic retinopathy.

    abstract：:Four patients who exhibited the greatest decline in the estimated glomerular filtration rate [12.3-23.5 ml/min/1.73 m(2)/year] among 320 patients with type 2 diabetes and were followed for a median of 6.8 years had several clinical features in common, including marked albuminuria, microhematuria, retinopathy and poor ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2013.01.031

    authors： Sakata M,Oniki K,Kita A,Kajiwara A,Uchiyashiki Y,Saruwatari J,Yoshida A,Jinnouchi H,Nakagawa K

    更新日期：2013-05-01 00:00:00

  • Accuracy of C-peptide:insulin molar ratio as a measure of hepatic removal of insulin.

    abstract：:We measured transhepatic C-peptide and insulin concentrations in plasma, and hepatic removal of insulin, to examine whether the practice of reporting the C-peptide:insulin molar ratio as a measure of the hepatic removal of insulin is valid. In anesthetized dogs (n = 6), during electromagnetic hepatic blood flow monito...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(87)80031-1

    authors： Berzins R,Wieczorek KR,Rajotte RV,Molnar GD,Tam YK,McGregor JR,Fawcett DM

    更新日期：1987-11-01 00:00:00