当前位置： SCI文献检索 > DIABETES RESEARCH AND CLINICAL PRACTICE期刊下所有文献 > Akt activation: A potential strategy to ameliorate insulin resistance.

Akt activation: A potential strategy to ameliorate insulin resistance.

Abstract：

:Insulin resistance is a hallmark of type 2 diabetes and obesity while the mechanism remains unclear. Current therapy to treat type 2 diabetes is metformin, the 5'-monophosphate-activated protein kinase (AMPK) activator, owing to the ability to augment peripheral glucose uptake. However, metformin also displays limitations, as AMPK activation remains intact and regular in most type 2 diabetes and metformin does not seem to facilitate peripheral insulin resistance. Evidence has shown that PI3K-Akt/PKB pathway could be induced via insulin and act as an important effector. Akt/PKB is capable of inducing a great number of downstream molecules, such as translocating glucose transporters GLUTs to the cell membrane thus increase glucose uptake. Hence, any defect in Akt/PKB pathway along with the downstream molecules could lead to insulin resistance. Inositol pyrophosphates, synthesized by inositol hexakisphosphate (IP6) kinase 1 (IP6K1) and competitive with 3,4,5-bisphosphate (PIP3) to bind the PH domain of Akt/PKB, demonstrate the ability to inhibit Akt signaling. In addition, IP6K1 knockout mice present increased insulin sensitivity and obesity resistance, indicating a novel therapeutic target in confronting insulin resistance. Taken together, we conclude that Akt activation is another potential strategy to ameliorate insulin resistance.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Zhang Z,Liu H,Liu J

doi

10.1016/j.diabres.2017.10.004

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

107092

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(17)30315-7

journal_volume

156

pub_type

杂志文章,评审

相关文献

DIABETES RESEARCH AND CLINICAL PRACTICE文献大全
  • Association of psychosocial factors with anxiety and depressive symptoms in Chinese patients with type 2 diabetes.

    abstract：OBJECTIVE:To investigate association of psychosocial factors with anxiety and depressive symptoms in Chinese type 2 diabetes patients. METHODS:Three hundred and four type 2 diabetes patients were inquired with a structured questionnaire about socio-demographic characteristics, psychological stress, coping styles, soci...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2007.10.014

    authors： Zhang CX,Chen YM,Chen WQ

    更新日期：2008-03-01 00:00:00

  • Impact of maternal height and gestational diabetes mellitus on offspring birthweight.

    abstract：AIMS:To evaluate the impact of gestational diabetes mellitus (GDM) and maternal height on offspring birthweight. METHODS:This is an observational cohort study, encompassing 4 111 Finnish primiparous women from Vantaa city, Finland, with singleton deliveries between 2009 and 2015. Data were obtained from the Finnish Me...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2019.01.004

    authors： Masalin S,Laine MK,Kautiainen H,Gissler M,Raina M,Pennanen P,Eriksson JG

    更新日期：2019-02-01 00:00:00

  • Cholecystokinin in the entero-insular axis.

    abstract：:Cholecystokinin (CCK) is a well-characterized gastrointestinal hormone which is released into the general circulation after meals. Targets for CCK include not only the gallbladder and the exocrine pancreas but also the endocrine pancreas. In this paper, we review the role of CCK from the perspective of the entero-insu...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,评审

    doi：10.1016/0168-8227(89)90092-2

    authors： Okabayashi Y,Otsuki M,Baba S

    更新日期：1989-01-01 00:00:00

  • The 3C study: coverage cost and care of type 1 diabetes in China--study design and implementation.

    abstract：AIM:To describe coverage, cost and care of type 1 diabetes (T1D) in 2 regions of China--Beijing and Shantou--including: METHODS:This is a mixed-methods descriptive study with three arms--coverage, cost and care. It is taking place in 4 tertiary hospitals, 3 secondary hospitals and 4 primary health facilities in Beijin...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.diabres.2011.10.016

    authors： McGuire H,Kissimova-Skarbek K,Whiting D,Ji L

    更新日期：2011-11-01 00:00:00

  • Reduced lung diffusion capacity in type 2 diabetes is independent of heart failure.

    abstract：:In a case-control analysis comparing 303 patients with diabetes and 303 without (matched on age, race, sex and height), diabetics had reduced lung diffusion (DLCO) independent of smoking, obesity, clinical heart failure, asymptomatic left ventricular systolic and diastolic dysfunction: DLCO (mean±SE: 15.5±0.9 vs. 16.4...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2012.02.014

    authors： Klein OL,Jones M,Lee J,Collard HR,Smith LJ

    更新日期：2012-06-01 00:00:00

  • Endothelial dysfunction and cardiovascular risk factors.

    abstract：UNLABELLED:The endothelium plays an integral role in the regulation of vascular tone, platelet activity, leukocyte adhesion, and thrombosis and is intimately involved in the development of atherosclerosis. Endothelial dysfunction has been observed in patients with established coronary artery disease or coronary risk fa...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabres.2008.12.013

    authors： Grover-Páez F,Zavalza-Gómez AB

    更新日期：2009-04-01 00:00:00

  • miR-221-3p and miR-222-3p downregulation promoted osteogenic differentiation of bone marrow mesenchyme stem cells through IGF-1/ERK pathway under high glucose condition.

    abstract：OBJECTIVE:This study aims to investigate the roles of miR-221-3p and miR-222-3p in the regulation of osteogenic differentiation of bone marrow mesenchyme stem cells (BMSCs) under high glucose condition. MATERIALS AND METHODS:The expreesions of miR-221-3p, miR-222-3p and insulin-like growth factor 1 (IGF-1) were detect...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108121

    authors： Gan K,Dong GH,Wang N,Zhu JF

    更新日期：2020-09-01 00:00:00

  • Peripheral neuropathy in the hands of people with diabetes mellitus.

    abstract：AIMS:Peripheral sensorimotor neuropathy is a recognised complication of diabetes mellitus however little attention has been given to its development in the hands. The aim of this study was to determine the prevalence of sensory impairment in the hands of participants with diabetes, the agreement between two measurement...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2016.06.010

    authors： Ennis SL,Galea MP,O'Neal DN,Dodson MJ

    更新日期：2016-09-01 00:00:00

  • Relationships between reduced heart rate variability and pre-clinical cardiovascular disease in patients with type 2 diabetes.

    abstract：AIMS:Reduced heart rate variability (HRV), an early sign of diabetic cardiovascular autonomic neuropathy (CAN), is associated with worse cardiovascular outcomes. The objective was to evaluate relationships between HRV parameters and three pre-clinical cardiovascular disease markers (left ventricular hypertrophy [LVH], ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2014.07.005

    authors： Cardoso CR,Moraes RA,Leite NC,Salles GF

    更新日期：2014-10-01 00:00:00

  • Outcome of pregnant diabetic patients in Benghazi (Libya) from 1984 to 1991.

    abstract：:During the period from 1 June 1984 to 1 June 1991, 988 pregnant diabetic patients were treated by a team of physicians and obstetricians in Benghazi Diabetic Clinic. Twelve patients were insulin-dependent (type 1) and 976 patients were non-insulin-dependent (type 2). Ninety patients were diagnosed for the first time d...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(93)90095-m

    authors： Kadiki OA,Reddy MR,Sahli MA,Shawar H,Rao S

    更新日期：1993-07-01 00:00:00

  • Subcutaneous antihistamine injection is effective to control a local allergic reaction to human insulin.

    abstract：:A 31-year-old woman, having a type-1 diabetes and an insulin allergy, was successfully treated with a subcutaneous antihistamine injection to the next continuous subcutaneous insulin infusion site. ...

    journal_title：Diabetes research and clinical practice

    pub_type： 信件

    doi：10.1016/j.diabres.2009.05.013

    authors： Imakado S,Hamada K,Atsumi Y

    更新日期：2009-09-01 00:00:00

  • Increased serum pigment epithelium-derived factor levels in type 1 diabetic patients with diabetic retinopathy.

    abstract：:Serum pigment epithelium-derived factor (PEDF) levels were significantly higher in type 1 diabetic patients with retinopathy (n=20, 10.38+/-3.87 microg/ml) compared to the patients without it (n=57, 7.68+/-2.80 microg/ml) (p=0.0013). Elevated PEDF levels may be related to the progression of diabetic retinopathy. ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2008.03.009

    authors： Katakami N,Kaneto H,Yamasaki Y,Matsuhisa M

    更新日期：2008-07-01 00:00:00

  • Lipasin, a biomarker of diabetic retinopathy.

    abstract：:The present study recruited 74 participants with type 2 diabetes, among which 23 had retinopathy. Those with retinopathy had a longer duration of diabetes and higher levels of lipasin compared with those without retinopathy. Logistic regression revealed that lipasin was independently and significantly associated with ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2016.01.029

    authors： Fang C,Huang Y,Guo H,Gao Y,Ji X,Hu J

    更新日期：2016-05-01 00:00:00

  • Outcome of clinical foot examination in relation to self-perceived health and glycaemic control in a group of urban Tanzanian diabetic patients.

    abstract：:Diabetic foot complications were studied in 153 patients at the university clinic in Dar es Salaam (56 insulin treated, 77 treated with oral agents and 20 with diet only). Neuropathy disability and symptoms scores were used to diagnose peripheral neuropathy (PN). Peripheral vascular disease (PVD) was classified as ank...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(97)00072-7

    authors： Wikblad K,Smide B,Bergström A,Kessi J,Mugusi F

    更新日期：1997-09-01 00:00:00

  • Impaired fasting glucose and risk of diabetes in Taiwan: follow-up over 3 years.

    abstract：:The purpose of this paper was to examine the relationship between fasting glucose levels and development of diabetes among residents of Penghu, Taiwan. From July 1995 to June 1996, a population-based cohort study was conducted among residents aged >or=40 years on the island of Penghu, Taiwan. Of the 1601 surveyed, 130...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(03)00037-8

    authors： Chen KT,Chen CJ,Gregg EW,Imperatore G,Narayan KM

    更新日期：2003-06-01 00:00:00

  • Glucose fluctuation and the resultant endothelial injury are correlated with pancreatic β cell dysfunction in patients with coronary artery disease.

    abstract：AIMS:We evaluated whether glucose fluctuation (GF) causes vascular endothelial injury and affects glucometabolic factors during lengthy oral glucose tolerance test (OGTT). METHODS:We enrolled consecutive 116 patients with coronary artery disease (CAD) who were performed coronary angiography and 4-h OGTT. Blood samples...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2017.07.007

    authors： Murata M,Adachi H,Oshima S,Kurabayashi M

    更新日期：2017-09-01 00:00:00

  • Glycated albumin is low in obese, non-diabetic children.

    abstract：:The current study evaluates the indices of glucose control for diabetics (i.e., glycated albumin (GA), hemoglobin A1c (HbA1c), plasma glucose (PG) and immuno-reactive insulin (IRI)) in non-diabetic children from a population-based cohort, and compares those values according to the presence of obesity to examine any di...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2005.07.008

    authors： Nishimura R,Kanda A,Sano H,Matsudaira T,Miyashita Y,Morimoto A,Shirasawa T,Kawaguchi T,Tajima N

    更新日期：2006-03-01 00:00:00

  • Islet amyloid polypeptide-derived amyloid deposition increases along with the duration of type 2 diabetes mellitus.

    abstract：:To investigate the involvement of islet amyloid polypeptide (IAPP) and amyloid deposits in the pathophysiology of this disease, we studied the relationship between IAPP-derived amyloid deposition and the clinical features in type 2 diabetes mellitus. We examined pancreata obtained from 37 type 2 diabetic subjects and ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(92)90062-v

    authors： Ohsawa H,Kanatsuka A,Mizuno Y,Tokuyama Y,Takada K,Mikata A,Makino H,Yoshida S

    更新日期：1992-01-01 00:00:00

  • The association of HLA-DP loci with autoimmune diabetes in Chinese.

    abstract：AIMS:To determine if HLA-DP loci independently contribute to classic type 1 diabetes (T1D) of all ages, childhood-onset T1D and latent autoimmune diabetes in adults (LADA) among Chinese Han population. METHODS:A total of 518 patients with classic T1D (Among them 180 participants manifested T1D between 1-14 years), 519...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108582

    authors： Xia Y,Li X,Huang G,Lin J,Luo S,Xie Z,Zhou Z

    更新日期：2020-12-08 00:00:00

  • Use of continuous intravenous insulin infusion in type 1 diabetic pregnancy complicated by nephrotic syndrome.

    abstract：:We report a case of nephrotic syndrome complicating pregnancy in a woman with CSII-treated type 1 diabetes. This was associated with deteriorating glycaemic control which was successfully managed with continuous intravenous insulin for the two weeks before delivery. ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2011.04.002

    authors： Dudding S,Whitelaw D

    更新日期：2011-07-01 00:00:00

  • Long-term effects of a reduced fat diet intervention on cardiovascular disease risk factors in individuals with glucose intolerance.

    abstract：:The long-term effects on cardiovascular disease risk factors of a reduced fat (RF), ad libitum diet were compared with usual diet (control, CD) in glucose intolerance individuals. Participants were 136 adults aged > or =40 years with 'glucose intolerance' (2h blood glucose 7-11.0 mmol/l) detected at a Diabetes Survey ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2003.09.001

    authors： Ley SJ,Metcalf PA,Scragg RK,Swinburn BA

    更新日期：2004-02-01 00:00:00

  • Exploring the characteristics of suboptimally controlled patients after 24weeks of basal insulin treatment: An individualized approach to intensification.

    abstract：AIM:To identify characteristics of suboptimally controlled patients with type 2 diabetes (T2DM) on basal insulin treatment who may benefit from intensive titration or further intensification of treatment. METHODS:A post hoc analysis of SOLVE: a 24-week, international, observational study conducted in 17,374 patients w...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2016.11.028

    authors： Khunti K,Damci T,Husemoen LL,Babu V,Liebl A

    更新日期：2017-01-01 00:00:00

  • Vascular complications in young Asian Indian patients with type 1 diabetes mellitus.

    abstract：:To determine the prevalence of micro vascular and macro vascular complications in Asian Indian Type 1 diabetic subjects. There has been no major report on the prevalence of vascular complications in Type 1 diabetic patients in India. This study was done in Type 1 diabetic patients, aged < or =20 years at diagnosis of ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(99)00134-5

    authors： Ramachandran A,Snehalatha C,Sasikala R,Satyavani K,Vijay V

    更新日期：2000-04-01 00:00:00

  • Diabetes in the Melanesian and Indian peoples of Fiji: a study of risk factors.

    abstract：:Epidemiological risk factor patterns for diabetes mellitus determined by hemoglobin A1 and fasting blood glucose criteria were compared in the biethnic (Melanesian and Indian) nation of Fiji. The 2 diagnostic criteria elicited essentially similar risk factor patterns in Indians but ranking of predictors was altered in...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(87)80050-5

    authors： Hoskins PL,Handelsman DJ,Hannelly T,Silink M,Yue DK,Turtle JR

    更新日期：1987-09-01 00:00:00

  • Prevalence of resistant hypertension and associated factors in Japanese subjects with type 2 diabetes.

    abstract：OBJECTIVE:The prevalence of treatment resistant hypertension (RH) depends on methods used for blood pressure (BP) measurements, goals of BP, and therapeutic efforts in terms of medication and adherence. We focused on diabetic subjects and explored the prevalence of RH in primary care practice. METHODS:In 1737 subjects...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2015.08.007

    authors： Yokoyama H,Araki S,Watanabe S,Honjo J,Okizaki S,Yamada D,Shudo R,Shimizu H,Sone H,Haneda M

    更新日期：2015-10-01 00:00:00

  • Central-peripheral distal axonopathy in the spontaneously diabetic BB-rat: ultrastructural and morphometric findings.

    abstract：:Central sensory nerve fibers were examined at distal (C3) and proximal (D12) levels of the gracile tract in the spontaneously diabetic BB-rat. Ultrastructural findings included early occurring malorientation of axoplasmic neurofilaments, axonal sequestration by honeycombing, and ensuing progressive axonal atrophy foll...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(86)80037-7

    authors： Sima AA,Yagihashi S

    更新日期：1985-01-01 00:00:00

  • Exendin-4 directly improves endothelial dysfunction in isolated aortas from obese rats through the cAMP or AMPK-eNOS pathways.

    abstract：AIMS:To determine whether exendin-4 might directly improve endothelial dysfunction in aorta isolated from high-fat diet-induced obese rats. METHODS:Wistar rats were randomly divided into control and obesity (OB) groups and fed. Vascular segments of obese rats were incubated in organ bath in the presence or absence of ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2012.04.001

    authors： Han L,Yu Y,Sun X,Wang B

    更新日期：2012-09-01 00:00:00

  • Where is Malaysia in the midst of the Asian epidemic of diabetes mellitus?

    abstract：:Population studies all over the world have clearly showed that the prevalence of Type 2 diabetes mellitus (DM) is escalating at phenomenal scale and very likely we are heading towards epidemic proportions. In 1985, the estimated population of diabetic individuals in the world was 30 million but by 1995 this figure soa...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(00)00175-3

    authors： Zaini A

    更新日期：2000-10-01 00:00:00

  • Cognition in the Finnish diabetes prevention study.

    abstract：:We studied cognition in the Finnish Diabetes Prevention Study (DPS), a trial of lifestyle intervention that prevented diabetes in persons with impaired glucose tolerance. Cognition was similar in the randomization arms 9 years after the intervention in 364 participants, suggesting that the intervention did not benefit...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.diabres.2015.02.023

    authors： Luchsinger JA,Lehtisalo J,Lindström J,Ngandu T,Kivipelto M,Ahtiluoto S,Ilanne-Parikka P,Keinänen-Kiukaanniemi S,Eriksson JG,Uusitupa M,Tuomilehto J,Finnish Diabetes Prevention Study (DPS).

    更新日期：2015-06-01 00:00:00

  • Carbohydrate metabolism and cardiovascular risk factors 4 years after a pregnancy complicated by gestational diabetes.

    abstract：AIMS:The aim of the present study was to determine the prevalence of abnormal glucose tolerance and the metabolic syndrome in a cohort of previously gestational diabetic (GDM) women 4 years after delivery. METHODS:Sixty-eight prior GDM and a control group of 39 women with normal glucose tolerance during pregnancy were...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2009.05.001

    authors： Madarász E,Tamás G,Tabák AG,Kerényi Z

    更新日期：2009-08-01 00:00:00