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Cholecystokinin in the entero-insular axis.

Abstract：

:Cholecystokinin (CCK) is a well-characterized gastrointestinal hormone which is released into the general circulation after meals. Targets for CCK include not only the gallbladder and the exocrine pancreas but also the endocrine pancreas. In this paper, we review the role of CCK from the perspective of the entero-insular axis, where CCK seems to function as one component of incretin and can raise insulin release synergistically with other incretin components. CCK also increases the sensitivity of B cells to subsequent glucose stimulation. At present, the role of CCK as incretin in disease states is uncertain. The pathophysiological role of CCK is likely to be revealed using CCK-specific radioimmunoassay and bioassay techniques and CCK receptor antagonists.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Okabayashi Y,Otsuki M,Baba S

doi

10.1016/0168-8227(89)90092-2

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

S79-85

eissn

0168-8227

issn

1872-8227

pii

0168-8227(89)90092-2

journal_volume

7 Suppl 1

pub_type

杂志文章,评审

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