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Diabetes mellitus in Friedreich Ataxia: A case series of 19 patients from the German-Austrian diabetes mellitus registry.

Abstract：

:Friedreich ataxia (FRDA) is a multisystem autosomal recessive disease with progressive clinical course involving the neuromuscular and endocrine system. Diabetes mellitus (DM) is one typical non-neurological manifestation, caused by beta cell failure and insulin resistance. Because of its rarity, knowledge on DM in FRDA is limited. Based on data from 200,301 patients with DM of the German-Austrian diabetes registry (DPV) and two exemplary patient reports, characteristics of patients with DM and FRDA are compared with classical type 1 or type 2 diabetes. Diabetes phenotype in FRDA is intermediate between type 1 and type 2 diabetes with ketoacidosis being frequent at presentation and blood glucose levels similar to T1Dm but higher than in T2Dm (356 ± 165 and 384 ± 203 mg/dl). 63.2% of FRDA patients received insulin monotherapy, 21% insulin plus oral antidiabetics and 15.8% lifestyle change only, applying similar doses of insulin in all three groups. FRDA patients did not show overweight and HbA1c levels were even lower than in T1Dm or T2Dm patients, respectively, indicating good overall diabetes control. FRDADm can be controlled by individualized treatment regimen with insulin or oral antidiabetics. Patients with DM in FRDA may show a relevant risk to ketoacidotic complications, which should be avoided.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Pappa A,Häusler MG,Veigel A,Tzamouranis K,Pfeifer MW,Schmidt A,Bökamp M,Haberland H,Wagner S,Brückel J,de Sousa G,Hackl L,Bollow E,Holl RW

doi

10.1016/j.diabres.2018.05.008

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

229-236

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(17)32029-6

journal_volume

141

pub_type

杂志文章

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