Altered expression of WFS1 and NOTCH2 genes associated with diabetic nephropathy in T2DM patients.

Abstract:

AIM:The increased incidence of type 2 diabetes mellitus (T2DM) and the importance of early identification and management of its complications, especially diabetic nephropathy (DN), have spotted the light on genetic factors that increase risk of T2DM and its related nephropathy. The present study aimed at investigating expression of (KCNJ11, ABCC8, JAZF1, WFS1, PPARG, NOTCH2 and EXOSC4) genes in peripheral blood of T2DM patients. METHOD:The study included 30 non-complicated T2DM patients, 30 patients with DN and 40 healthy controls. Quantitative Real Time PCR Array was used to study gene expression. RESULTS:NOTCH2 showed higher expression while KCNJ11, JAZF1, WFS1 and PPARG genes showed lower expression in DN patients compared to non-complicated patients. KCNJ11, JAZF1, WFS1, PPARG, and EXOSC4 expression showed significant negative correlation with microalbumin, while NOTCH2 expression was significantly positively correlated with microalbumin. AS regard HbA1c and studied genes expression, there was significant negative correlation between WFS1 expression and HbA1c, while NOTCH2, KCNJ11, JAZF1, PPARG, EXOSC4 expression didn't show significant correlation with HbA1c. Risk ratio of studied genes expression showed that WFS1 and NOTCH2 had highest risk ratio (30) and highest sensitivity and specificity, in relation to DN and they were the best predictors in the group of studied genes at cut off value of ≤0.861 for WFS1 and ≥0.678 for NOTCH2. CONCLUSION:Altered expression of WFS1 and NOTCH2 genes may play a role in pathogenesis and development of DN in patients with T2DM. These results may contribute in early identification and management of DN.

authors

Sharaf SA,Kantoush NA,Ayoub DF,Ibrahim AA,Abdelaal AA,Aziz RA,ElHefnawi MM,Ahmed AN

doi

10.1016/j.diabres.2018.03.053

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

304-313

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(18)30064-0

journal_volume

140

pub_type

杂志文章
  • Antiatheromatic effects of insulin.

    abstract::Despite numerous publications according to which insulin promotes atherosclerosis, there are many observations in the last fifteen years suggesting that insulin has antiatherogenic properties. Insulin has vasodilatory, antithrombotic and anti-inflammatory effects. A good glycemic control contributes to the maximum eff...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/S0168-8227(11)70024-9

    authors: Karamitsos DT

    更新日期:2011-08-01 00:00:00

  • Diabetes prevalence and determinants in adults in China mainland from 2000 to 2010: a systematic review.

    abstract:AIMS:To systematically review trends in diabetes mellitus (DM) prevalence in adults in China over the last 10 years and to identify the determinants of these trends. METHODS:A systematic search was conducted for studies published between 2000 and 2010. Studies reporting DM prevalence were included if they met the pre-...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/j.diabres.2012.05.010

    authors: Li H,Oldenburg B,Chamberlain C,O'Neil A,Xue B,Jolley D,Hall R,Dong Z,Guo Y

    更新日期:2012-11-01 00:00:00

  • Short sleep duration and type 2 diabetes enhance the risk of cardiovascular events in hypertensive patients.

    abstract:AIMS:We tested the hypothesis that short sleep duration is not only a risk factor for diabetes, but that the two conditions in combination would be associated with the risk of incident cardiovascular disease (CVD). METHODS:We analyzed 1255 hypertensive patients (mean age: 70.4±9.9 years) with (N=299) and without diabe...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2012.09.014

    authors: Eguchi K,Hoshide S,Ishikawa S,Shimada K,Kario K

    更新日期:2012-12-01 00:00:00

  • Health care use by diabetic patients in the Netherlands: patterns and predicting factors.

    abstract:AIMS:Diabetic patients require care from a variety of health care providers, but little is known about their actual use of health care. Aims of this study were to (1) obtain information on health care use by diabetic patients in the Netherlands, (2) distinguish patterns of health care utilisation among these patients, ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/s0168-8227(03)00116-5

    authors: El Fakiri F,Foets M,Rijken M

    更新日期:2003-09-01 00:00:00

  • Injection related anxiety in insulin-treated diabetes.

    abstract::The presence of injection related anxiety and phobia may influence compliance, glycaemic control and quality of life in patients with insulin-treated diabetes. Unselected consecutive, insulin-treated patients attending a diabetes clinic for follow-up, completed a standardised questionnaire providing an injection anxie...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/s0168-8227(99)00099-6

    authors: Zambanini A,Newson RB,Maisey M,Feher MD

    更新日期:1999-12-01 00:00:00

  • High rate of hypoglycemia in 6770 type 2 diabetes patients with comorbid dementia: A multicenter cohort study on 215,932 patients from the German/Austrian diabetes registry.

    abstract:AIMS:Dementia and type 2 diabetes (T2D) are two major phenomena in older people. To compare anti-hyperglycemic therapy and diabetes-related comorbidities between elderly T2D patients with or without comorbid dementia. METHODS:215,932 type 2 diabetes patients aged ≥ 40 years (median [Q1;Q3]: 70.4 [61.2;77.7] years) fro...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.diabres.2015.10.026

    authors: Prinz N,Stingl J,Dapp A,Denkinger MD,Fasching P,Jehle PM,Merger S,Mühldorfer S,Pieper U,Schuler A,Zeyfang A,Holl RW,DPV initiative.

    更新日期:2016-02-01 00:00:00

  • A hospital-based cross-sectional study to develop an estimation formula for 2-h post-challenge plasma glucose for screening impaired glucose tolerance.

    abstract:AIMS:To create and validate an estimation formula for 2-h post-challenge plasma glucose (2-hPG) as an alternative to oral glucose tolerance test (OGTT) for impaired glucose tolerance (IGT) screening. METHODS:380 Japanese subjects (57.6% males, aged 58.5 (14.0); mean (SD) years) undergoing OGTT were included in this ho...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2013.05.013

    authors: Kondo Y,Harada N,Sozu T,Hamasaki A,Yamane S,Muraoka A,Harada T,Shibue K,Nasteska D,Joo E,Sasaki K,Inagaki N

    更新日期:2013-08-01 00:00:00

  • Cholecystokinin in the entero-insular axis.

    abstract::Cholecystokinin (CCK) is a well-characterized gastrointestinal hormone which is released into the general circulation after meals. Targets for CCK include not only the gallbladder and the exocrine pancreas but also the endocrine pancreas. In this paper, we review the role of CCK from the perspective of the entero-insu...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/0168-8227(89)90092-2

    authors: Okabayashi Y,Otsuki M,Baba S

    更新日期:1989-01-01 00:00:00

  • Increased insulin binding is not involved in the improved insulin effectiveness of gestational diabetics after hypoenergetic dieting.

    abstract::125I-Insulin binding to monocytes from 14 gestational diabetics was measured before and after 6 weeks of treatment with a 5500 kJ, low-fat, low-sucrose diet. After the hypoenergetic feeding of gestational diabetics, fasting plasma concentrations of glucose (P less than 0.01) and insulin (P less than 0.05) decreased si...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/s0168-8227(86)80044-4

    authors: Pedersen O,Beck-Nielsen H,Richelsen B,Bak J,Klebe J

    更新日期:1985-01-01 00:00:00

  • Glycemic control and its correlates in patients with diabetes in Venezuela: results from a nationwide survey.

    abstract:AIMS:To determine the prevalence of inadequate glycemic control and its correlates in a large multicenter survey of Venezuelan patients with diabetes. METHODS:A cross-sectional study in a sample of adult patients with diabetes, attending health centers in Venezuela. Information about diabetes, current medications, com...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.diabres.2009.12.014

    authors: Moreira ED Jr,Neves RC,Nunes ZO,de Almeida MC,Mendes AB,Fittipaldi JA,Ablan F,Venezuelan Diabetes Investigators' Group.

    更新日期:2010-03-01 00:00:00

  • Prevalence of depression and its associations with cardio-metabolic control in Aboriginal and Anglo-Celt patients with type 2 diabetes: the Fremantle Diabetes Study Phase II.

    abstract:AIMS:To determine the prevalence and associates of depression in Aboriginal and Anglo-Celt (AC) Australians with type 2 diabetes. METHODS:Community-based patients were screened using the Patient Health Questionnaire (PHQ-9) as part of detailed assessment. The prevalence of any current depression, major depression and ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2014.12.014

    authors: Davis TM,Hunt K,Bruce DG,Starkstein S,Skinner T,McAullay D,Davis WA

    更新日期:2015-03-01 00:00:00

  • Using technology to support care in gestational diabetes mellitus: Quantitative outcomes of an exploratory randomised control trial of adjunct telemedicine for gestational diabetes mellitus (TeleGDM).

    abstract:AIMS:The increasing incidence and prevalence of gestational diabetes mellitus (GDM) on a background of limited resources calls for innovative approaches healthcare provision. Our aim was to explore the effects of telemedicine supported GDM care on a range of health service utilisation and maternal and foetal outcomes. ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.diabres.2018.05.049

    authors: Rasekaba TM,Furler J,Young D,Liew D,Gray K,Blackberry I,Lim WK

    更新日期:2018-08-01 00:00:00

  • A cardiac magnetic resonance imaging study of electrocardiographic Q waves in type 2 diabetes: the Fremantle Diabetes Study.

    abstract::To investigate the evolution and significance of Q waves in type 2 diabetes, we studied 36 patients of mean (+/-S.D.) age 69.9+/-7.1 years from the longitudinal observational Fremantle Diabetes Study (FDS). All had (i) neither history/symptoms of coronary heart disease (CHD) nor pathological Q waves at FDS recruitment...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2008.06.016

    authors: Kondola S,Davis WA,Dembo LG,Davis TM

    更新日期:2008-10-01 00:00:00

  • Aggravation of albuminuria by metabolic syndrome in type 2 diabetic Asian subjects.

    abstract:AIMS:We investigated the relationship of urinary albumin excretion (UAE) to metabolic syndrome and type 2 diabetes in Asian. METHODS:A total of 446 subjects (187 without diabetes and 259 with type 2 diabetes) were enrolled in this study. The components of metabolic syndrome, high sensitivity C-reactive protein (hs-CRP...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2008.05.010

    authors: Lee IT,Huang CN,Lee WJ,Lee HS,Sheu WH

    更新日期:2008-09-01 00:00:00

  • Feasibility, reliability and validity of the Iranian version of the Diabetes Quality of Life Brief Clinical Inventory (IDQOL-BCI).

    abstract:AIMS:To validate and culturally adapt the Diabetes-specific Quality of Life Brief Clinical Inventory (DQOL-BCI) for the Iranian population. METHODS:After translation - back translation, content validity was assessed utilizing a panel of six experts. Based on a sample of 180 diabetic patients referred to two Diabetics ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2011.12.030

    authors: Mirfeizi M,Jafarabadi MA,Toorzani ZM,Mohammadi SM,Azad MD,Mohammadi AV,Teimori Z

    更新日期:2012-05-01 00:00:00

  • All-trans retinoic acid improves the viability of ischemic skin flaps in diabetic rat models.

    abstract:AIMS:Endothelial progenitor cells (EPCs) play a critical role in neovascularization, which enhances proliferation under all-trans retinoic acid (ATRA) treatment. However, the effects of ATRA on the skin flap survival in diabetic flap ischemia remains unknown. METHODS:Ischemic random skin flaps were made in 40 diabetic...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2018.06.019

    authors: Weng Z,Wang C,Zhang C,Xu J,Chai Y,Jia Y,Han P,Wen G

    更新日期:2018-08-01 00:00:00

  • Early screening and treatment of gestational diabetes in high-risk women improves maternal and neonatal outcomes: A retrospective clinical audit.

    abstract:AIMS:Evidence suggests that screening for gestational diabetes (GDM) occurs too late in pregnancy, when changes in glucose metabolism and fetal growth rates can already be detected. In August 2016 NHS Lothian began screening women with risk factors for GDM during early pregnancy (11-13 weeks). We hypothesised that an e...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2018.09.013

    authors: Ryan DK,Haddow L,Ramaesh A,Kelly R,Johns EC,Denison FC,Dover AR,Reynolds RM

    更新日期:2018-10-01 00:00:00

  • Relation of habitual snoring with components of metabolic syndrome in Korean adults.

    abstract:AIMS:To examine the association between habitual snoring and components of the metabolic syndrome in Korean adults. Whether these associations are independent of obesity was also explored. METHODS:Four thousand five hundred and six men and 5041 women aged 40-69 years from the Korean Health and Genome Study were examin...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.diabres.2005.06.011

    authors: Cho N,Joo S,Kim J,Abbott RD,Kim J,Kimm K,Shin C

    更新日期:2006-03-01 00:00:00

  • Aspirin in the primary prevention of cardiovascular disease in diabetes mellitus: A new perspective.

    abstract::Although the improved control of hyperglycaemia and other cardiovascular risk factors was associated with a parallel decline of atherosclerotic cardiovascular disease (ASCVD) and death in both type 1 (T1) and type 2 (T2) diabetes mellitus (DM), the burden of death and hospitalization for ASCVD remains significantly hi...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/j.diabres.2020.108008

    authors: Rocca B,Patrono C

    更新日期:2020-02-01 00:00:00

  • Are recommended standards for diabetes care met in Central and South America? A systematic review.

    abstract:AIMS:We evaluated quality of diabetes care in low- and middle-income countries (LMIC) of Central and South America by documenting the ability to meet the guideline-recommended targets. We also identified barriers to achieving goals of treatment and characteristics of successful programs. METHODS:We searched the Nation...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/j.diabres.2013.01.010

    authors: Mudaliar U,Kim WC,Kirk K,Rouse C,Narayan KM,Ali M

    更新日期:2013-06-01 00:00:00

  • Insulin administration may trigger pancreatic beta-cell destruction in patients with type 2 diabetes.

    abstract::Insulin administration causes various types of immune response to insulin. However, there have been no reports that insulin administration triggers pancreatic beta-cell destruction in diabetic patients. We evaluated three patients who had suffered from type 2 diabetes or impaired glucose tolerance for 5-30 years. Afte...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2007.08.031

    authors: Nakamura M,Nishida W,Yamada Y,Chujo D,Watanabe Y,Imagawa A,Hanafusa T,Kawasaki E,Onuma H,Osawa H,Makino H

    更新日期:2008-02-01 00:00:00

  • Inhibition of multifunctional dipeptidyl peptidase-IV: is there a risk of oncological and immunological adverse effects?

    abstract::Inhibitors of dipeptidyl peptidase-IV (DPP-IV) are a novel class of anti-diabetes drugs; inhibiting the breakdown of incretins, they increase their biological availability and decrease thus blood glucose levels. However, in addition to regulating glucose homeostasis, DPP-IV has many diverse functions, such as modulati...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/j.diabres.2010.02.017

    authors: Stulc T,Sedo A

    更新日期:2010-05-01 00:00:00

  • Utilization patterns and cost of complementary and alternative medicine compared to conventional medicine in patients with type 2 diabetes mellitus.

    abstract:AIMS:We evaluated the use and annual cost of complementary and alternative medicine (CAM) compared to conventional medicine in type 2 diabetes mellitus (DM) in the Korean population. METHODS:We analyzed the database of 2752 DM patients obtained from the Korean National Diabetes Program (KNDP). The cost data of convent...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2011.03.031

    authors: Kim HJ,Chun KH,Kim DJ,Han SJ,Kim YS,Woo JT,Park Y,Nam MS,Baik SH,Ahn KJ,Lee KW

    更新日期:2011-07-01 00:00:00

  • Fibre-enriched buckwheat pasta modifies blood glucose response compared to corn pasta in individuals with type 1 diabetes and celiac disease: Acute randomized controlled trial.

    abstract:AIM:People with type 1 diabetes and celiac disease (T1D&CD) have high blood glucose variability. Processed gluten-free foods have shown to induce a worse metabolic profile whereas naturally gluten-free foods may represent healthier options. On the other hand, dietary fibre has shown to reduce postprandial glycemic excu...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2019.02.013

    authors: Vetrani C,Bozzetto L,Giorgini M,Cavagnuolo L,Di Mattia E,Cipriano P,Mangione A,Todisco A,Inghilterra G,Giacco A,Annuzzi G,Rivellese AA

    更新日期:2019-03-01 00:00:00

  • Metformin use in elderly population with diabetes reduced the risk of dementia in a dose-dependent manner, based on the Korean NHIS-HEALS cohort.

    abstract:AIMS:The aim of this study is to investigate the association between metformin usage and dementia in an elderly Korean population. METHODS:Participants were divided into five groups: metformin non-users with diabetes mellitus (DM), metformin users with DM (low-, mid-, and high-users), and non-diabetic Individuals. Dem...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2020.108496

    authors: Kim Y,Kim HS,Lee JW,Kim YS,You HS,Bae YJ,Lee HC,Han YE,Choi EA,Kim J,Kang HT

    更新日期:2020-12-01 00:00:00

  • Electrodiagnostic testing in diabetic neuropathy: Which limb?

    abstract::Electrodiagnosis of subclinical diabetic neuropathies by nerve conduction studies remains challenging. The question arises about which nerves should be tested and what the best electrodiagnostic protocol to make an early diagnosis of diabetic neuropathies would be. On the basis of our findings and other evidence, whic...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2015.07.009

    authors: Rota E,Cocito D

    更新日期:2015-10-01 00:00:00

  • Impact of COVID-19 lockdown on glycemic control in patients with type 1 diabetes.

    abstract:INTRODUCTION:The COVID-19 pandemic has forced governments to take exceptional measures to minimize its spread, imposing lockdown policies. The aim of this study was to evaluate the impact of lockdown on type 1 diabetes (T1D) glycemic control. MATERIAL AND METHODS:People with T1D using flash glucose monitoring were inc...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/j.diabres.2020.108348

    authors: Fernández E,Cortazar A,Bellido V

    更新日期:2020-08-01 00:00:00

  • Cell-mediated immune responses to GAD and beta-casein in type 1 diabetes mellitus in Thailand.

    abstract::We measured the cell-mediated immune response to GAD and bovine beta-casein in 38 type 1 and 37 type 2 diabetic patients who visited diabetic clinics or who were hospitalized in Bangkok, Thailand, and in 43 normal controls, by using a lymphoproliferation assay. Positive results against GAD were found in 29/38 (76.3%) ...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/s0168-8227(01)00322-9

    authors: Banchuin N,Boonyasrisawat W,Vannasaeng S,Dharakul T,Yenchitsomanus PT,Deerochanawong C,Ploybutr S,Sriussadaporn S,Pasurakul T

    更新日期:2002-03-01 00:00:00

  • Nocturnal penile tumescence monitoring with stamps in impotent diabetics.

    abstract::The usefulness of nocturnal penile tumescence (NPT) monitoring with stamps was evaluated in diabetic males with impotence. The stamps, which were similar in paper and size to Japanese 10-yen postage stamps, were wrapped around the penis before sleep and the stamp ring was checked for breakage the next morning. Clinica...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章

    doi:10.1016/s0168-8227(88)80018-4

    authors: Takahashi Y,Hirata Y

    更新日期:1988-02-19 00:00:00

  • Prevention of type 2 diabetes: a review.

    abstract::One of the major public health challenges of the 21st century is type 2 diabetes. WHO estimates that by 2025 as many as 200-300 million people worldwide will have developed the disease. A distressing increase in children is perhaps the most alarming sign of something going wrong. Roughly half of the risk of type 2 dia...

    journal_title:Diabetes research and clinical practice

    pub_type: 杂志文章,评审

    doi:10.1016/j.diabres.2006.09.020

    authors: Hussain A,Claussen B,Ramachandran A,Williams R

    更新日期:2007-06-01 00:00:00