当前位置： SCI文献检索 > DIABETES RESEARCH AND CLINICAL PRACTICE期刊下所有文献 > Effect of insulin on serum amino-terminal propeptide of type III procollagen in non-insulin-dependent diabetes mellitus.

Effect of insulin on serum amino-terminal propeptide of type III procollagen in non-insulin-dependent diabetes mellitus.

Abstract：

:The effect of insulin on the serum levels of the amino-terminal propeptide of type III procollagen (PIIINP) was investigated in patients with non-insulin-dependent diabetes mellitus, whose disease was unsatisfactorily controlled by oral drugs. Before insulin therapy the PIIINP values of the patients (3.2 +/- 1.3 micrograms/l, n = 38) varied within the range of healthy subjects (3.1 +/- 0.6 micrograms/l, n = 50, NS). Insulin therapy (6-20 IU at bedtime plus the oral drugs) improved the glycemic control and increased the serum PIIINP during a 4 week (3.1 +/- 0.9 to 3.8 +/- 1.1 micrograms/l, P less than 0.01, n = 8) and an 8 week period (3.2 +/- 1.3 to 3.8 +/- 1.6 micrograms/l, P less than 0.001, n = 22). The values were still elevated after 6 months on insulin (3.5 +/- 1.5 to 4.0 +/- 1.7 micrograms/l, P less than 0.01, n = 12). Placebo-insulin did not alter the concentration of PIIINP (3.1 +/- 0.6 to 2.8 +/- 0.6 micrograms/l, NS, n = 8) whereas the glycemic control improved and body weight decreased. The PIIINP values correlated with fasting insulin before (r = 0.403, P less than 0.05, n = 30) and after the therapy (r = 0.452, P less than 0.001, n = 60). Insulin therapy, while correcting the hormone deficiency and restoring glucose and protein metabolism, seems to activate the synthesis of type III procollagen in patients with NIDDM. This may promote the atherosclerotic process.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Sotaniemi EA,Stenbäck FG,Risteli L,Vuori JA,Rautio A,Huupponen R,Risteli J

doi

10.1016/0168-8227(92)90096-a

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

209-15

issue

3

eissn

0168-8227

issn

1872-8227

pii

0168-8227(92)90096-A

journal_volume

17

pub_type

临床试验,杂志文章,随机对照试验

相关文献

DIABETES RESEARCH AND CLINICAL PRACTICE文献大全
  • A real-world study in patients with type 2 diabetes mellitus treated with gliclazide modified-release during fasting: DIA-RAMADAN.

    abstract：AIMS:To explore the real-world safety and effectiveness of gliclazide modified release (MR) in patients with type 2 diabetes mellitus (T2DM) fasting during Ramadan. METHODS:DIA-RAMADAN (NCT04132934) was a prospective, international, observational study conducted in nine countries. Patients >18 years of age with T2DM (...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108154

    authors： Hassanein M,Al Sifri S,Shaikh S,Abbas Raza S,Akram J,Pranoto A,Rudijanto A,Shaltout I,Fariduddin M,Mohd Izani Wan Mohamed W,Al Awadi F,Alessa T,DIA-RAMADAN study investigators.

    更新日期：2020-05-01 00:00:00

  • Insulin requirement profiles of short-term intensive insulin therapy in patients with newly diagnosed type 2 diabetes and its association with long-term glycemic remission.

    abstract：AIMS:To investigate the insulin requirement profiles during short-term intensive continuous subcutaneous insulin infusion (CSII) in patients with newly diagnosed type 2 diabetes and its relationship with long-term glycemic remission. METHODS:CSII was applied in 104 patients with newly diagnosed type 2 diabetes. Daily ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.diabres.2015.02.011

    authors： Liu L,Ke W,Wan X,Zhang P,Cao X,Deng W,Li Y

    更新日期：2015-05-01 00:00:00

  • Waist circumference cut-off points for the diagnosis of metabolic syndrome in Iranian adults.

    abstract：AIMS:Central obesity, a prominent feature of metabolic syndrome (MetS), is commonly assessed by gender- and ethnicity-specific waist circumference (WC) cut-off values. Since 2006, the recommended WC cut-offs by the International Diabetes Federation (IDF) for Europeans are used in Iran because of limited data availabili...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2008.07.009

    authors： Esteghamati A,Ashraf H,Rashidi A,Meysamie A

    更新日期：2008-10-01 00:00:00

  • Glycaemia and utilisation of technology across the lifespan of adults with type 1 diabetes: Results of the Australian National Diabetes Audit (ANDA).

    abstract：AIMS:To evaluate the utilisation of technologies and associated glycaemia among adults with type 1 diabetes. METHODS:De-identified data from adults with type 1 diabetes (≥18 years old) in the Australian National Diabetes Audit (ANDA)-2019 were analysed. Proportions using insulin pumps or injections with continuous glu...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108609

    authors： Pease A,Szwarcbard N,Earnest A,Andrikopoulos S,Wischer N,Zoungas S

    更新日期：2020-12-10 00:00:00

  • High serum oxytocin is associated with metabolic syndrome in older men - The MINOS study.

    abstract：AIM:Oxytocin regulates food intake, carbohydrate and lipid metabolism, and urinary sodium excretion. We assessed the association between serum oxytocin levels and presence of metabolic syndrome (MetS) in older men. METHODS:Cross-sectional study was performed in 540 volunteer men aged 50-85yrs from the MINOS cohort. Ox...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2016.09.022

    authors： Szulc P,Amri EZ,Varennes A,Panaia-Ferrari P,Fontas E,Goudable J,Chapurlat R,Breuil V

    更新日期：2016-12-01 00:00:00

  • Ethnic disparities in the association of impaired fasting glucose with the 10-year cumulative incidence of type 2 diabetes.

    abstract：AIMS:Evidence of ethnic disparities in the conversion of prediabetes to type 2 diabetes is scarce. We studied the association of impaired fasting glucose (IFG) and fasting plasma glucose (FPG) with the 10-year cumulative incidence of type 2 diabetes in three ethnic groups. METHODS:We analyzed data for 90 South-Asian S...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2013.10.014

    authors： Admiraal WM,Holleman F,Snijder MB,Peters RJ,Brewster LM,Hoekstra JB,Stronks K,van Valkengoed IG

    更新日期：2014-01-01 00:00:00

  • Changes in apoptosis and Bcl-2 expression in human hyperglycemic, term placental trophoblast.

    abstract：:Apoptosis and its associated regulatory mechanisms are physiological events crucial to the maintenance of placental homeostasis; imbalance of these processes, however, such as occurs under various pathological conditions, may compromise placenta function and, consequently, pregnancy success. Increased apoptosis occurs...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2005.12.014

    authors： Sgarbosa F,Barbisan LF,Brasil MA,Costa E,Calderon IM,Gonçalves CR,Bevilacqua E,Rudge MV

    更新日期：2006-08-01 00:00:00

  • Strong association of common variants in the IGF2BP2 gene with type 2 diabetes in Lebanese Arabs.

    abstract：OBJECTIVE:Several genome-wide association studies and replication analyses have identified common variation at the insulin-like binding protein 2 (IGF2BP2) gene to be associated with type 2 diabetes (T2DM). The aim of this study was to replicate in a Lebanese Arab population identified associations of IGF2BP2 variants ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2011.12.026

    authors： Nemr R,Echtay A,Dashti EA,Almawi AW,Al-Busaidi AS,Keleshian SH,Irani-Hakime N,Almawi WY

    更新日期：2012-05-01 00:00:00

  • Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertension.

    abstract：AIMS:The aim of this study was to investigate whether the polymorphism of DDAH2 is associated with type 2 diabetes and hypertension in Korean population. METHODS:Total 605 subjects were included in this study: 403 patients with type 2 diabetes and 202 non-diabetic control subjects. The SNP rs805304 and rs2272592 in DD...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2012.04.015

    authors： Seo HA,Kim SW,Jeon EJ,Jeong JY,Moon SS,Lee WK,Kim JG,Lee IK,Park KG

    更新日期：2012-10-01 00:00:00

  • The effect of intensive risk factor management in type 2 diabetes on inflammatory biomarkers.

    abstract：AIMS:To determine whether intensive risk factor management reduced markers of inflammation in middle-aged and older people with type 2 diabetes who either had, or were at risk for cardiovascular disease (CVD), and whether these effects were mediated by adiposity. METHODS:The Action to Control Cardiovascular Risk in Di...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.diabres.2011.09.027

    authors： Samaropoulos XF,Light L,Ambrosius WT,Marcovina SM,Probstfield J,Goff DC Jr

    更新日期：2012-03-01 00:00:00

  • Prevalence of resistant hypertension and associated factors in Japanese subjects with type 2 diabetes.

    abstract：OBJECTIVE:The prevalence of treatment resistant hypertension (RH) depends on methods used for blood pressure (BP) measurements, goals of BP, and therapeutic efforts in terms of medication and adherence. We focused on diabetic subjects and explored the prevalence of RH in primary care practice. METHODS:In 1737 subjects...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2015.08.007

    authors： Yokoyama H,Araki S,Watanabe S,Honjo J,Okizaki S,Yamada D,Shudo R,Shimizu H,Sone H,Haneda M

    更新日期：2015-10-01 00:00:00

  • Prevalence of diabetes in Murcia (Spain): a Mediterranean area characterised by obesity.

    abstract：:The aim of this cross-sectional study was to describe the prevalence of total, known and unknown diabetes mellitus and impaired fasting glucose (IFG) in the population of Murcia (SE Spain), a Mediterranean area with a high prevalence of obesity. Therefore, 2562 subjects (>or=20 years) were selected by stratified rando...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.diabres.2005.06.009

    authors： Valverde JC,Tormo MJ,Navarro C,Rodríguez-Barranco M,Marco R,Egea JM,Pérez-Flores D,Ortolá JB,González-Sicilia L,Tébar J,Sánchez-Pinilla M,Flores M,Cava J

    更新日期：2006-02-01 00:00:00

  • Does working memory training improve dietary self-care in type 2 diabetes mellitus? Results of a double blind randomised controlled trial.

    abstract：AIMS:Controlling food intake despite adequate knowledge remains a struggle for many people with type 2 diabetes. The present study investigated whether working memory training can reduce food intake and improve glycaemic control. It also examined training effects on cognition, food cravings, and dietary self-efficacy a...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.diabres.2018.07.005

    authors： Whitelock V,Nouwen A,Houben K,van den Akker O,Rosenthal M,Higgs S

    更新日期：2018-09-01 00:00:00

  • Isoprostanes, a marker of lipid peroxidation, may not be involved in the development of glucose intolerance.

    abstract：:We investigated whether isoprostanes, as a marker of lipid peroxidation, may be involved in the development of impaired glucose tolerance (IGT) or diabetes. Using a nested case-control study, we tracked the changes in isoprostane levels, insulin sensitivity (IS) and beta-cell function (BCF) in Afro-Jamaicans who progr...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2006.08.003

    authors： Boyne MS,Sargeant LA,Bennett FI,Wilks RJ,Cooper RS,Forrester TE

    更新日期：2007-04-01 00:00:00

  • Current status of diabetes management in elderly Koreans with diabetes.

    abstract：:Knowledge about the current status of diabetes management is indispensable for the improvement of diabetes management. We performed a survey to investigate the current trend of diabetes management in elderly Koreans, at eight hospitals located throughout the country. A total of 539 patients with type 2 diabetes older ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.diabres.2007.01.047

    authors： Noh JH,Kim SK,Cho YJ,Nam HU,Kim IJ,Jeong IK,Choi MG,Yoo HJ,Ahn YH,Bae HY,Jang HC

    更新日期：2007-09-01 00:00:00

  • High frequency of autonomic as well as peripheral neuropathy in patients with malnutrition-related diabetes mellitus.

    abstract：:We assessed peripheral and autonomic nerve function in 27 diabetics. Ten had malnutrition-related diabetes mellitus (MRDM), eight insulin-dependent diabetes mellitus (IDDM), and nine non-insulin-dependent diabetes mellitus (NIDDM). The frequency of peripheral neuropathy was 70, 78 and 13% in MRDM, NIDDM and IDDM respe...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(88)80088-3

    authors： Sutjahjo A,Taniguchi H,Hendromartono,Tjokroprawiro A,Baba S

    更新日期：1988-09-05 00:00:00

  • Incidence of COVID-19 infection and prevalence of diabetes, obesity and hypertension according to altitude in Peruvian population.

    abstract：:To investigate the cumulative incidence and mortality of COVID-19 and the prevalence of comorbidities such as diabetes, obesity and hypertension in regions with different altitude levels ranging from sea level to high altitude. METHODOLOGY: Analytical study in which we correlated secondary data obtained from reports o...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108463

    authors： Seclén SN,Nunez-Robles E,Yovera-Aldana M,Arias-Chumpitaz A

    更新日期：2020-11-01 00:00:00

  • Diabetes care in refugee camps: the experience of UNRWA.

    abstract：:United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) was established in 1949 and has delivered health care services for over 65 years. The epidemiological transition in disease burden is changing the context in which UNRWA's health programme operates and poses new challenges that requ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabres.2015.01.035

    authors： Shahin Y,Kapur A,Seita A

    更新日期：2015-04-01 00:00:00

  • Pericytes and the prevention of diabetic retinopathy.

    abstract：:Diabetic retinopathy is a leading cause of blindness and one of the hallmarks of early diabetic retinopathy is death of pericytes. I studied the effect of glycated albumin (GA) on the retinal pericyte death and assessed the protective effects of some well-known antioxidant materials. GA produced a progressive cytotoxi...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2003.10.027

    authors： Kim J

    更新日期：2004-12-01 00:00:00

  • High prevalence and early onset of cardiac autonomic neuropathy among South Indian type 2 diabetic patients with nephropathy.

    abstract：OBJECTIVE:This study was conducted to assess the adverse effects of diabetic nephropathy on cardiovascular autonomic neuropathy (CAN) in South Indian Type 2 diabetic patients. METHODS:Comparison was made between Type 2 diabetic patients with nephropathy (group 1, n=25), Type 2 diabetic patients without nephropathy (gr...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(00)00127-3

    authors： Viswanathan V,Prasad D,Chamukuttan S,Ramachandran A

    更新日期：2000-06-01 00:00:00

  • Demographic and clinical features of critically ill patients with COVID-19 in Greece: The burden of diabetes and obesity.

    abstract：AIMS:The aim of the study was to investigate the association between type-2 diabetes mellitus, other underlying diseases and obesity with the outcomes of critically ill Covid-19 patients in Greece. METHODS:In this retrospective observational multi-centre study, data and outcomes of 90 RNA 2109-nCoV confirmed criticall...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.diabres.2020.108331

    authors： Halvatsiotis P,Kotanidou A,Tzannis K,Jahaj E,Magira E,Theodorakopoulou M,Konstandopoulou G,Gkeka E,Pourzitaki C,Kapravelos N,Papoti S,Sileli M,Gogos C,Velissaris D,Markou N,Stefanatou E,Vlachogianni G,Aimoniotou E,Kom

    更新日期：2020-08-01 00:00:00

  • Smoking, blood glucose control, and locus of control beliefs in people with type 1 diabetes mellitus.

    abstract：:The relations between blood glucose control (HbA(1c)), smoking, and health-related diabetes locus of control beliefs were studied in a consecutive adult sample of 187 patients with Type 1 diabetes who were free of diabetes complications. Those who were smokers (n=32) had poorer HbA(1c) values than non-smokers [7.5+/-1...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(00)00169-8

    authors： Stenström U,Andersson P

    更新日期：2000-10-01 00:00:00

  • Hemoglobin A1c predicts heart failure hospitalization independent of baseline cardiac function or B-type natriuretic peptide level.

    abstract：AIMS:Diabetes is a major risk factor for heart failure (HF). We examined whether baseline HbA1c level predicts HF incidence independent of other HF risk factors, including baseline cardiac structural and functional abnormalities. METHODS:In patients with type 2 diabetes, multivariable Cox regression models were constr...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2014.02.009

    authors： Kishimoto I,Makino H,Ohata Y,Tamanaha T,Tochiya M,Kada A,Ishihara M,Anzai T,Shimizu W,Yasuda S,Ogawa H

    更新日期：2014-05-01 00:00:00

  • Effect of Sanguis draxonis (a Chinese traditional herb) on the formation of insulin resistance in rats.

    abstract：:Sanguis draxonis (SD) is a Chinese traditional herb that is prescribed for the handling of diabetic disorders. In this study, the effects of an oral administration of SD at dosages of 100, 300, and 500 mg kg(-1) once a day, respectively, on the formation of insulin resistance were investigated in vivo in two models of...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2004.08.011

    authors： Hou Z,Zhang Z,Wu H

    更新日期：2005-04-01 00:00:00

  • Management of type 2 diabetes in Western Australian metropolitan general practice.

    abstract：:The purpose of this study was: (1) to record GP opinions, practices and outcomes for the care of Type 2 Diabetes Mellitus (DM2), (2) compare practice facilities and process of care with a criterion of recommended competent care and (3) determine if there were any differences between vocationally registered and non-voc...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(94)90061-2

    authors： Kamien M,Ward AM,Mansfield F,Fatovich B,Mather C,Anstey K

    更新日期：1994-12-31 00:00:00

  • Nocturnal penile tumescence monitoring with stamps in impotent diabetics.

    abstract：:The usefulness of nocturnal penile tumescence (NPT) monitoring with stamps was evaluated in diabetic males with impotence. The stamps, which were similar in paper and size to Japanese 10-yen postage stamps, were wrapped around the penis before sleep and the stamp ring was checked for breakage the next morning. Clinica...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(88)80018-4

    authors： Takahashi Y,Hirata Y

    更新日期：1988-02-19 00:00:00

  • Influence of cardiovascular autonomic neuropathy on atherogenesis and heart function in patients with type 1 diabetes.

    abstract：AIM:Cardiovascular autonomic neuropathy (CAN) increases mortality of patients with type 1 diabetes (Type 1 DM). We set out to find out whether the presence of CAN in asymptomatic, normotensive Type 1 DM affects endothelial function (marker of atherogenesis) and left ventricle function (marker of cardiomyopathy). METHO...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2008.09.007

    authors： Lacigova S,Bartunek L,Cechurova D,Visek J,Gruberova J,Krcma M,Jankovec Z,Rusavy Z,Zourek M

    更新日期：2009-01-01 00:00:00

  • Blood glucose and nocturnal blood pressure in African and Caucasian men: The SABPA study.

    abstract：AIM:To investigate the relationship between nocturnal blood pressure and chronically elevated blood glucose to determine if these elevated blood glucose concentrations contribute to a non-dipping blood pressure, especially in high-risk groups such as Africans. METHODS:Nocturnal blood pressures and blood glucose levels...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2011.05.011

    authors： Lammertyn L,Schutte AE,Schutte R

    更新日期：2011-08-01 00:00:00

  • Injection related anxiety in insulin-treated diabetes.

    abstract：:The presence of injection related anxiety and phobia may influence compliance, glycaemic control and quality of life in patients with insulin-treated diabetes. Unselected consecutive, insulin-treated patients attending a diabetes clinic for follow-up, completed a standardised questionnaire providing an injection anxie...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(99)00099-6

    authors： Zambanini A,Newson RB,Maisey M,Feher MD

    更新日期：1999-12-01 00:00:00

  • Abnormal transient rise in hepatic glucose production after oral glucose in non-insulin-dependent diabetic subjects.

    abstract：:A transient rise in hepatic glucose production (HGP) after an oral glucosa load has been reported in some insulin-resistant states such as in obese fa/fa Zucker rats. The aim of this study was to determine whether this rise in HGP also occurs in subjects with established non-insulin-dependent diabetes mellitus (NIDDM)...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(95)01067-n

    authors： Thorburn A,Litchfield A,Fabris S,Proietto J

    更新日期：1995-05-01 00:00:00