Abstract:
AIMS:The aim of this study is to investigate the association between metformin usage and dementia in an elderly Korean population. METHODS:Participants were divided into five groups: metformin non-users with diabetes mellitus (DM), metformin users with DM (low-, mid-, and high-users), and non-diabetic Individuals. Dementia was defined with primary diagnostic dementia codes according to the 10th edition of the International Classification of Diseases. To compare the incidence rate of dementia among the five groups, Kaplan-Meier estimates and log-rank test were employed. Also, to control the confounding factors, Cox proportional hazards regression models were fitted in a sequential adjustment. RESULTS:The median follow-up was 12.4 years. The overall incidence rate of dementia was 11.3% (8.4% in men and 13.9% in women). Compared with metformin non-users, hazard ratios (95% confidence intervals) of low-, mid-, and high-users and non-diabetic individuals for dementia were 0.97 (0.73-1.28), 0.77 (0.58-1.01), 0.48 (0.35-0.67), and 0.98 (0.84-1.15), respectively, in men, respectively, and 0.90 (0.65-0.98), 0.61 (0.50-0.76), 0.46 (0.36-0.58), and 0.92 (0.81-1.04), respectively, in women, after full adjustment of confounding variables. CONCLUSIONS:Metformin use in an elderly population with DM reduced dementia risk in a dose-response manner.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Kim Y,Kim HS,Lee JW,Kim YS,You HS,Bae YJ,Lee HC,Han YE,Choi EA,Kim J,Kang HTdoi
10.1016/j.diabres.2020.108496subject
Has Abstractpub_date
2020-12-01 00:00:00pages
108496eissn
0168-8227issn
1872-8227pii
S0168-8227(20)30750-6journal_volume
170pub_type
杂志文章abstract::Diabetic retinopathy is a leading cause of blindness and one of the hallmarks of early diabetic retinopathy is death of pericytes. I studied the effect of glycated albumin (GA) on the retinal pericyte death and assessed the protective effects of some well-known antioxidant materials. GA produced a progressive cytotoxi...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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更新日期:2004-12-01 00:00:00
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journal_title:Diabetes research and clinical practice
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abstract:AIMS:We estimated the number of live births worldwide and by IDF Region who developed hyperglycaemia in pregnancy in 2013, including total diabetes in pregnancy (known and previously undiagnosed diabetes) and gestational diabetes. METHODS:Studies reporting prevalence of hyperglycaemia first-detected in pregnancy (form...
journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
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更新日期:2011-01-01 00:00:00
abstract::Cardiovascular disease is a major chronic complication of obesity and diabetes. Due to several patients with obesity and diabetes, it is necessary to urgently explore early diagnostic biomarkers and innovative therapeutic strategies to prevent the progression of cardiovascular diseases. Recently, microRNAs (also known...
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abstract:BACKGROUND:We examined the accuracy of random capillary glucose (RCG) and two noninvasive screening methods, the ADA diabetes risk test (DRT) and skin fluorescence spectroscopy (SFS) as measured by Scout DS for detecting HbA1c-defined dysglycemia or type 2 diabetes in an at-risk cohort. METHODS:Subjects were recruited...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,多中心研究
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,评审
doi:10.1016/0168-8227(94)90272-0
更新日期:1994-10-01 00:00:00
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
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doi:10.1016/j.diabres.2008.07.009
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journal_title:Diabetes research and clinical practice
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doi:10.1016/s0168-8227(00)00196-0
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journal_title:Diabetes research and clinical practice
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doi:10.1016/j.diabres.2015.12.020
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journal_title:Diabetes research and clinical practice
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doi:10.1016/j.diabres.2013.01.014
更新日期:2013-04-01 00:00:00
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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journal_title:Diabetes research and clinical practice
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-12-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2008.06.016
更新日期:2008-10-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/0168-8227(94)90040-x
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2020.108035
更新日期:2020-03-01 00:00:00
abstract::A 31-year-old woman, having a type-1 diabetes and an insulin allergy, was successfully treated with a subcutaneous antihistamine injection to the next continuous subcutaneous insulin infusion site. ...
journal_title:Diabetes research and clinical practice
pub_type: 信件
doi:10.1016/j.diabres.2009.05.013
更新日期:2009-09-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2004.02.020
更新日期:2004-10-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,评审
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/0168-8227(92)90083-4
更新日期:1992-05-01 00:00:00
abstract::Over the years, strong evidence have been accumulated in favor of the beneficial effects of camel milk on glucose homeostasis with significant anti-diabetic properties in both human and animal diabetic models. However, the cellular and molecular mechanisms involved in such effects remain not understood. In this review...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,评审
doi:10.1016/j.diabres.2018.11.006
更新日期:2018-12-01 00:00:00
abstract:UNLABELLED:Over 1 year, a survey on contraception and obstetric history was performed on a cohort of 667 Caucasian fertile diabetic women (446, type 1 and 201, type 2) living in Italy. RESULTS:Of these women, 30.4% used hormonal contraceptives, 12.0% intra-uterine device (IUD), 10.7% declared they used no contraceptio...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2004.07.020
更新日期:2005-03-01 00:00:00