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The functions of microRNA-208 in the heart.

Abstract：

:Cardiovascular disease is a major chronic complication of obesity and diabetes. Due to several patients with obesity and diabetes, it is necessary to urgently explore early diagnostic biomarkers and innovative therapeutic strategies to prevent the progression of cardiovascular diseases. Recently, microRNAs (also known as miRNAs) have emerged as important players in heart disease and energy regulation. MiRNAs are a group of small, highly conserved non-coding RNA molecules that regulate gene expression by suppressing the translation of messenger RNA of target genes or by promoting mRNA degradation. These act as a class of potential biomarkers and may provide key information in diagnosing common diseases such as tumors, tissue damage, and autoimmune diseases. Among all the known miRNAs, microRNA-208 (miR-208) is specifically expressed in myocardial cells and showed close association with the development of cardiac diseases, such as myocardial hypertrophy, cardiac fibrosis, myocardial infarction, arrhythmia, and heart failure. However, the functions and underlying mechanisms of miR-208 in heart are still unclear. In this review, we highlighted the novel insights of miR-208 functions and associated mechanisms in the regulation of cardiac diseases.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Zhao X,Wang Y,Sun X

doi

10.1016/j.diabres.2020.108004

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

108004

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(19)31593-1

journal_volume

160

pub_type

杂志文章,评审

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